INTERACTION BETWEEN PHENYTOIN AND VALPROATE

Name: Work Video:
Duration: 3 min 30 s
Description: Displacement of Phenytoin from plasma proteins by valproate causes a reduction in total serum Phenytoin levels. However, no adjustment of Phenytoin dosage is warranted, unless clinically indicated, since the free Phenytoin levels remain unchanged.
LN Sansom; Roy G. Beran; Graham J. Schapel
{'id': 'https://openalex.org/W2443686743', 'doi': 'https://doi.org/10.5694/j.1326-5377.1980.tb112200.x', 'title': 'INTERACTION BETWEEN PHENYTOIN AND VALPROATE', 'display_name': 'INTERACTION BETWEEN PHENYTOIN AND VALPROATE', 'publication_year': 1980, 'publication_date': '1980-08-01', 'ids': {'openalex': 'https://openalex.org/W2443686743', 'doi': 'https://doi.org/10.5694/j.1326-5377.1980.tb112200.x', 'mag': '2443686743', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/6776391'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.5694/j.1326-5377.1980.tb112200.x', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S13978405', 'display_name': 'The Medical Journal of Australia', 'issn_l': '0025-729X', 'issn': ['0025-729X', '1326-5377'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5034115111', 'display_name': 'LN Sansom', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': True, 'raw_author_name': 'L. N. Sansom', 'raw_affiliation_strings': ['School of Pharmacy, S.A. Institute of Technology, North Terrace, Adelaide, S.A., 5000'], 'affiliations': [{'raw_affiliation_string': 'School of Pharmacy, S.A. Institute of Technology, North Terrace, Adelaide, S.A., 5000', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5013598339', 'display_name': 'Roy G. Beran', 'orcid': 'https://orcid.org/0000-0002-5884-0606'}, 'institutions': [{'id': 'https://openalex.org/I1320133117', 'display_name': 'Royal Adelaide Hospital', 'ror': 'https://ror.org/00carf720', 'country_code': 'AU', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1320133117', 'https://openalex.org/I4392738059']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'R. C. Beran', 'raw_affiliation_strings': ['Department of Neurology, Royal Adelaide Hospital, Adelaide, S.A., 5000'], 'affiliations': [{'raw_affiliation_string': 'Department of Neurology, Royal Adelaide Hospital, Adelaide, S.A., 5000', 'institution_ids': ['https://openalex.org/I1320133117']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5111799425', 'display_name': 'Graham J. Schapel', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'G. J. Schapel', 'raw_affiliation_strings': ['The Queen Elizabeth Hospital, Woodville Road, Woodville, S.A., 5011'], 'affiliations': [{'raw_affiliation_string': 'The Queen Elizabeth Hospital, Woodville Road, Woodville, S.A., 5011', 'institution_ids': []}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5034115111'], 'corresponding_institution_ids': [], 'apc_list': {'value': 3090, 'currency': 'USD', 'value_usd': 3090, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': False, 'cited_by_count': 3, 'citation_normalized_percentile': {'value': 0.617217, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 68, 'max': 71}, 'biblio': {'volume': '2', 'issue': '4', 'first_page': '212', 'last_page': '212'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12229', 'display_name': 'Pharmacological Effects and Toxicity Studies', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2735', 'display_name': 'Pediatrics, Perinatology and Child Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12229', 'display_name': 'Pharmacological Effects and Toxicity Studies', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2735', 'display_name': 'Pediatrics, Perinatology and Child Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T13768', 'display_name': 'Oral and gingival health research', 'score': 0.9851, 'subfield': {'id': 'https://openalex.org/subfields/3611', 'display_name': 'Pharmacy'}, 'field': {'id': 'https://openalex.org/fields/36', 'display_name': 'Health Professions'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12547', 'display_name': 'Pharmaceutical studies and practices', 'score': 0.9818, 'subfield': {'id': 'https://openalex.org/subfields/2735', 'display_name': 'Pediatrics, Perinatology and Child Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C2778337148', 'wikidata': 'https://www.wikidata.org/wiki/Q410400', 'display_name': 'Phenytoin', 'level': 3, 'score': 0.9889438}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.46400657}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.44358605}, {'id': 'https://openalex.org/C2775858608', 'wikidata': 'https://www.wikidata.org/wiki/Q576618', 'display_name': 'Anticonvulsant', 'level': 3, 'score': 0.41622}, {'id': 'https://openalex.org/C2778186239', 'wikidata': 'https://www.wikidata.org/wiki/Q41571', 'display_name': 'Epilepsy', 'level': 2, 'score': 0.39400512}, {'id': 'https://openalex.org/C118552586', 'wikidata': 'https://www.wikidata.org/wiki/Q7867', 'display_name': 'Psychiatry', 'level': 1, 'score': 0.064047635}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.5694/j.1326-5377.1980.tb112200.x', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S13978405', 'display_name': 'The Medical Journal of Australia', 'issn_l': '0025-729X', 'issn': ['0025-729X', '1326-5377'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Clean water and sanitation', 'score': 0.64, 'id': 'https://metadata.un.org/sdg/6'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 10, 'referenced_works': ['https://openalex.org/W1977079818', 'https://openalex.org/W1982489437', 'https://openalex.org/W2041378367', 'https://openalex.org/W2045406186', 'https://openalex.org/W2070891569', 'https://openalex.org/W2094462303', 'https://openalex.org/W2333649931', 'https://openalex.org/W2440271915', 'https://openalex.org/W2469907948', 'https://openalex.org/W3021472365'], 'related_works': ['https://openalex.org/W2681294209', 'https://openalex.org/W2112021888', 'https://openalex.org/W2079731406', 'https://openalex.org/W2067322405', 'https://openalex.org/W2042200406', 'https://openalex.org/W2035329234', 'https://openalex.org/W2020454380', 'https://openalex.org/W2002689460', 'https://openalex.org/W1999345588', 'https://openalex.org/W1977834784'], 'abstract_inverted_index': {'Displacement': [0], 'of': [1, 19], 'Phenytoin': [2, 14, 20, 30], 'from': [3], 'plasma': [4], 'proteins': [5], 'by': [6], 'valproate': [7], 'causes': [8], 'a': [9], 'reduction': [10], 'in': [11], 'total': [12], 'serum': [13], 'levels.': [15], 'However,': [16], 'no': [17], 'adjustment': [18], 'dosage': [21], 'is': [22], 'warranted,': [23], 'unless': [24], 'clinically': [25], 'indicated,': [26], 'since': [27], 'the': [28], 'free': [29], 'levels': [31], 'remain': [32], 'unchanged.': [33]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2443686743', 'counts_by_year': [], 'updated_date': '2024-12-11T17:21:01.453713', 'created_date': '2016-06-24'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
