Publication Information

{'id': 'https://openalex.org/W2414976871', 'doi': 'https://doi.org/10.1093/pcp/pcw094', 'title': 'Functional Analysis of Amorpha-4,11-Diene Synthase (ADS) Homologs from Non-Artemisinin-Producing<i>Artemisia</i>Species: The Discovery of Novel Koidzumiol and (+)-α-Bisabolol Synthases', 'display_name': 'Functional Analysis of Amorpha-4,11-Diene Synthase (ADS) Homologs from Non-Artemisinin-Producing<i>Artemisia</i>Species: The Discovery of Novel Koidzumiol and (+)-α-Bisabolol Synthases', 'publication_year': 2016, 'publication_date': '2016-06-07', 'ids': {'openalex': 'https://openalex.org/W2414976871', 'doi': 'https://doi.org/10.1093/pcp/pcw094', 'mag': '2414976871', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/27273626'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1093/pcp/pcw094', 'pdf_url': 'https://academic.oup.com/pcp/article-pdf/57/8/1678/17119941/pcw094.pdf', 'source': {'id': 'https://openalex.org/S110997964', 'display_name': 'Plant and Cell Physiology', 'issn_l': '0032-0781', 'issn': ['0032-0781', '1471-9053'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://academic.oup.com/pcp/article-pdf/57/8/1678/17119941/pcw094.pdf', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5040297094', 'display_name': 'Paskorn Muangphrom', 'orcid': 'https://orcid.org/0000-0003-1863-0150'}, 'institutions': [{'id': 'https://openalex.org/I98285908', 'display_name': 'Osaka University', 'ror': 'https://ror.org/035t8zc32', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I98285908']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Paskorn Muangphrom', 'raw_affiliation_strings': ['Department of Biotechnology, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka, 565-0871 Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Biotechnology, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka, 565-0871 Japan', 'institution_ids': ['https://openalex.org/I98285908']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5006610161', 'display_name': 'Hikaru Seki', 'orcid': 'https://orcid.org/0000-0002-6426-0368'}, 'institutions': [{'id': 'https://openalex.org/I98285908', 'display_name': 'Osaka University', 'ror': 'https://ror.org/035t8zc32', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I98285908']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Hikaru Seki', 'raw_affiliation_strings': ['Department of Biotechnology, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka, 565-0871 Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Biotechnology, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka, 565-0871 Japan', 'institution_ids': ['https://openalex.org/I98285908']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5033326454', 'display_name': 'Munenori Suzuki', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I98285908', 'display_name': 'Osaka University', 'ror': 'https://ror.org/035t8zc32', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I98285908']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Munenori Suzuki', 'raw_affiliation_strings': ['Department of Biotechnology, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka, 565-0871 Japan', 'KNC Laboratories Co., Ltd., 3-2-34 Takatsukadai, Nishi-ku, Kobe, Hyogo, 651-2271 Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Biotechnology, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka, 565-0871 Japan', 'institution_ids': ['https://openalex.org/I98285908']}, {'raw_affiliation_string': 'KNC Laboratories Co., Ltd., 3-2-34 Takatsukadai, Nishi-ku, Kobe, Hyogo, 651-2271 Japan', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5091264791', 'display_name': 'Aya Komori', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I98285908', 'display_name': 'Osaka University', 'ror': 'https://ror.org/035t8zc32', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I98285908']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Aya Komori', 'raw_affiliation_strings': ['Department of Biotechnology, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka, 565-0871 Japan', 'KNC Laboratories Co., Ltd., 3-2-34 Takatsukadai, Nishi-ku, Kobe, Hyogo, 651-2271 Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Biotechnology, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka, 565-0871 Japan', 'institution_ids': ['https://openalex.org/I98285908']}, {'raw_affiliation_string': 'KNC Laboratories Co., Ltd., 3-2-34 Takatsukadai, Nishi-ku, Kobe, Hyogo, 651-2271 Japan', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5018841560', 'display_name': 'Mika Nishiwaki', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I98285908', 'display_name': 'Osaka University', 'ror': 'https://ror.org/035t8zc32', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I98285908']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Mika Nishiwaki', 'raw_affiliation_strings': ['Department of Biotechnology, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka, 565-0871 Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Biotechnology, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka, 565-0871 Japan', 'institution_ids': ['https://openalex.org/I98285908']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5029115751', 'display_name': 'Ryota Mikawa', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I98285908', 'display_name': 'Osaka University', 'ror': 'https://ror.org/035t8zc32', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I98285908']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Ryota Mikawa', 'raw_affiliation_strings': ['Department of Biotechnology, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka, 565-0871 Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Biotechnology, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka, 565-0871 Japan', 'institution_ids': ['https://openalex.org/I98285908']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5047501829', 'display_name': 'Ery Odette Fukushima', 'orcid': 'https://orcid.org/0000-0003-4099-4292'}, 'institutions': [{'id': 'https://openalex.org/I98285908', 'display_name': 'Osaka University', 'ror': 'https://ror.org/035t8zc32', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I98285908']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Ery Odette Fukushima', 'raw_affiliation_strings': ['Continuing Professional Development Center, Department of Biotechnology, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka, 565-0871 Japan', 'Department of Biotechnology, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka, 565-0871 Japan'], 'affiliations': [{'raw_affiliation_string': 'Continuing Professional Development Center, Department of Biotechnology, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka, 565-0871 Japan', 'institution_ids': ['https://openalex.org/I98285908']}, {'raw_affiliation_string': 'Department of Biotechnology, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka, 565-0871 Japan', 'institution_ids': ['https://openalex.org/I98285908']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5029514297', 'display_name': 'Toshiya Muranaka', 'orcid': 'https://orcid.org/0000-0003-1058-2473'}, 'institutions': [{'id': 'https://openalex.org/I98285908', 'display_name': 'Osaka University', 'ror': 'https://ror.org/035t8zc32', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I98285908']}], 'countries': ['JP'], 'is_corresponding': True, 'raw_author_name': 'Toshiya Muranaka', 'raw_affiliation_strings': ['Department of Biotechnology, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka, 565-0871 Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Biotechnology, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka, 565-0871 Japan', 'institution_ids': ['https://openalex.org/I98285908']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5029514297'], 'corresponding_institution_ids': ['https://openalex.org/I98285908'], 'apc_list': {'value': 2880, 'currency': 'USD', 'value_usd': 2880, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 0.831, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 18, 'citation_normalized_percentile': {'value': 0.673497, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 90, 'max': 91}, 'biblio': {'volume': '57', 'issue': '8', 'first_page': '1678', 'last_page': '1688'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11882', 'display_name': 'Plant biochemistry and biosynthesis', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11882', 'display_name': 'Plant biochemistry and biosynthesis', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12817', 'display_name': 'Pharmacological Effects of Natural Compounds', 'score': 0.9739, 'subfield': {'id': 'https://openalex.org/subfields/3004', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/30', 'display_name': 'Pharmacology, Toxicology and Pharmaceutics'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10252', 'display_name': 'Microbial Natural Products and Biosynthesis', 'score': 0.9689, 'subfield': {'id': 'https://openalex.org/subfields/2736', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/artemisia-annua', 'display_name': 'Artemisia annua', 'score': 0.9425646}, {'id': 'https://openalex.org/keywords/sesquiterpene-lactone', 'display_name': 'Sesquiterpene lactone', 'score': 0.5028781}], 'concepts': [{'id': 'https://openalex.org/C2779691961', 'wikidata': 'https://www.wikidata.org/wiki/Q1308044', 'display_name': 'Artemisia annua', 'level': 5, 'score': 0.9425646}, {'id': 'https://openalex.org/C2776120307', 'wikidata': 'https://www.wikidata.org/wiki/Q426921', 'display_name': 'Artemisinin', 'level': 4, 'score': 0.92915154}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.5764111}, {'id': 'https://openalex.org/C553450214', 'wikidata': 'https://www.wikidata.org/wiki/Q851162', 'display_name': 'Biosynthesis', 'level': 3, 'score': 0.5527599}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.50472486}, {'id': 'https://openalex.org/C2779243328', 'wikidata': 'https://www.wikidata.org/wiki/Q424405', 'display_name': 'Sesquiterpene lactone', 'level': 3, 'score': 0.5028781}, {'id': 'https://openalex.org/C112243037', 'wikidata': 'https://www.wikidata.org/wiki/Q22327117', 'display_name': 'ATP synthase', 'level': 3, 'score': 0.42712086}, {'id': 'https://openalex.org/C2776211264', 'wikidata': 'https://www.wikidata.org/wiki/Q80218', 'display_name': 'Sesquiterpene', 'level': 2, 'score': 0.4198238}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.41363814}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.3638082}, {'id': 'https://openalex.org/C59822182', 'wikidata': 'https://www.wikidata.org/wiki/Q441', 'display_name': 'Botany', 'level': 1, 'score': 0.20383671}, {'id': 'https://openalex.org/C2778371730', 'wikidata': 'https://www.wikidata.org/wiki/Q311383', 'display_name': 'Plasmodium falciparum', 'level': 3, 'score': 0.15163323}, {'id': 'https://openalex.org/C2778048844', 'wikidata': 'https://www.wikidata.org/wiki/Q12156', 'display_name': 'Malaria', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D019883', 'descriptor_name': 'Alkyl and Aryl Transferases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D019306', 'descriptor_name': 'Artemisia', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': True}, {'descriptor_ui': 'D007887', 'descriptor_name': 'Fabaceae', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': True}, {'descriptor_ui': 'D006899', 'descriptor_name': 'Mixed Function Oxygenases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D010088', 'descriptor_name': 'Oxidoreductases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D010940', 'descriptor_name': 'Plant Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D019883', 'descriptor_name': 'Alkyl and Aryl Transferases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019883', 'descriptor_name': 'Alkyl and Aryl Transferases', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D000595', 'descriptor_name': 'Amino Acid Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000962', 'descriptor_name': 'Antimalarials', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D000962', 'descriptor_name': 'Antimalarials', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000962', 'descriptor_name': 'Antimalarials', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D019306', 'descriptor_name': 'Artemisia', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D019306', 'descriptor_name': 'Artemisia', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D031172', 'descriptor_name': 'Artemisia annua', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': False}, {'descriptor_ui': 'D031172', 'descriptor_name': 'Artemisia annua', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D031172', 'descriptor_name': 'Artemisia annua', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D037621', 'descriptor_name': 'Artemisinins', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D037621', 'descriptor_name': 'Artemisinins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D037621', 'descriptor_name': 'Artemisinins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D053898', 'descriptor_name': 'Biosynthetic Pathways', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007887', 'descriptor_name': 'Fabaceae', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007887', 'descriptor_name': 'Fabaceae', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D018506', 'descriptor_name': 'Gene Expression Regulation, Plant', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007783', 'descriptor_name': 'Lactones', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D007783', 'descriptor_name': 'Lactones', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D007783', 'descriptor_name': 'Lactones', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006899', 'descriptor_name': 'Mixed Function Oxygenases', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D006899', 'descriptor_name': 'Mixed Function Oxygenases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000081222', 'descriptor_name': 'Monocyclic Sesquiterpenes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010088', 'descriptor_name': 'Oxidoreductases', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D010088', 'descriptor_name': 'Oxidoreductases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010802', 'descriptor_name': 'Phylogeny', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010940', 'descriptor_name': 'Plant Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010940', 'descriptor_name': 'Plant Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D000081223', 'descriptor_name': 'Polycyclic Sesquiterpenes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011106', 'descriptor_name': 'Polyisoprenyl Phosphates', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011106', 'descriptor_name': 'Polyisoprenyl Phosphates', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D011106', 'descriptor_name': 'Polyisoprenyl Phosphates', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D016415', 'descriptor_name': 'Sequence Alignment', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012717', 'descriptor_name': 'Sesquiterpenes', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D012717', 'descriptor_name': 'Sesquiterpenes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012717', 'descriptor_name': 'Sesquiterpenes', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1093/pcp/pcw094', 'pdf_url': 'https://academic.oup.com/pcp/article-pdf/57/8/1678/17119941/pcw094.pdf', 'source': {'id': 'https://openalex.org/S110997964', 'display_name': 'Plant and Cell Physiology', 'issn_l': '0032-0781', 'issn': ['0032-0781', '1471-9053'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/27273626', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1093/pcp/pcw094', 'pdf_url': 'https://academic.oup.com/pcp/article-pdf/57/8/1678/17119941/pcw094.pdf', 'source': {'id': 'https://openalex.org/S110997964', 'display_name': 'Plant and Cell Physiology', 'issn_l': '0032-0781', 'issn': ['0032-0781', '1471-9053'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/15', 'score': 0.55, 'display_name': 'Life on land'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 53, 'referenced_works': ['https://openalex.org/W1963983283', 'https://openalex.org/W1969962785', 'https://openalex.org/W1987657458', 'https://openalex.org/W1990598982', 'https://openalex.org/W1992306108', 'https://openalex.org/W2000864731', 'https://openalex.org/W2007400541', 'https://openalex.org/W2011221723', 'https://openalex.org/W2011660372', 'https://openalex.org/W2016104676', 'https://openalex.org/W2023095686', 'https://openalex.org/W2023533798', 'https://openalex.org/W2027583333', 'https://openalex.org/W2033812623', 'https://openalex.org/W2044435718', 'https://openalex.org/W2048804410', 'https://openalex.org/W2049445090', 'https://openalex.org/W2060813180', 'https://openalex.org/W2062644645', 'https://openalex.org/W2062686084', 'https://openalex.org/W2066854128', 'https://openalex.org/W2068460381', 'https://openalex.org/W2072132373', 'https://openalex.org/W2076421866', 'https://openalex.org/W2077422152', 'https://openalex.org/W2078327726', 'https://openalex.org/W2080592564', 'https://openalex.org/W2080943164', 'https://openalex.org/W2087192299', 'https://openalex.org/W2093931964', 'https://openalex.org/W2094192382', 'https://openalex.org/W2097706568', 'https://openalex.org/W2106882534', 'https://openalex.org/W2112762465', 'https://openalex.org/W2126658049', 'https://openalex.org/W2128446472', 'https://openalex.org/W2129447528', 'https://openalex.org/W2148556623', 'https://openalex.org/W2149125081', 'https://openalex.org/W2149202606', 'https://openalex.org/W2149852370', 'https://openalex.org/W2152443621', 'https://openalex.org/W2162903401', 'https://openalex.org/W2165818994', 'https://openalex.org/W2168736102', 'https://openalex.org/W2311203695', 'https://openalex.org/W2329986607', 'https://openalex.org/W2501864638', 'https://openalex.org/W2519522915', 'https://openalex.org/W2952013485', 'https://openalex.org/W30455059', 'https://openalex.org/W4232087855', 'https://openalex.org/W50468539'], 'related_works': ['https://openalex.org/W4378591422', 'https://openalex.org/W3160805922', 'https://openalex.org/W2559821950', 'https://openalex.org/W2259291304', 'https://openalex.org/W2097457822', 'https://openalex.org/W2087848252', 'https://openalex.org/W2064909918', 'https://openalex.org/W2063095212', 'https://openalex.org/W2033803943', 'https://openalex.org/W113539199'], 'abstract_inverted_index': {'The': [0, 189], 'production': [1], 'of': [2, 135, 137, 160, 185, 192, 212], 'artemisinin,': [3], 'the': [4, 78, 82, 107, 112, 132, 138, 148, 158, 183, 193, 209, 213], 'most': [5], 'effective': [6], 'antimalarial': [7], 'compound,': [8], 'is': [9], 'limited': [10], 'to': [11, 66, 105, 164, 187, 199], 'Artemisia': [12, 43, 58, 116], 'annua.': [13, 219], 'Enzymes': [14], 'involved': [15], 'in': [16, 41, 55, 69, 85, 94, 111, 114, 122, 157, 182, 202, 217], 'artemisinin': [17, 33, 83], 'biosynthesis': [18, 84], 'include': [19], 'amorpha-4,11-diene': [20, 23], 'synthase': [21], '(ADS),': [22], '12-monooxygenase': [24], '(CYP71AV1)': [25], 'and': [26, 34, 50, 72, 127, 174], 'artemisinic': [27], 'aldehyde': [28], 'Δ(11)13': [29], 'reductase': [30], '(DBR2).': [31], 'Although': [32], 'its': [35], 'specific': [36], 'intermediates': [37, 76], 'are': [38], 'not': [39], 'detected': [40, 119], 'other': [42], 'species,': [44], 'we': [45, 100], 'reported': [46], 'previously': [47], 'that': [48, 147], 'CYP71AV1': [49], 'DBR2': [51], 'homologs': [52, 121, 140], 'were': [53], 'expressed': [54], 'some': [56], 'non-artemisinin-producing': [57], 'plants.': [59], 'These': [60, 87], 'homologous': [61, 104, 198], 'enzymes': [62], 'showed': [63, 177], 'similar': [64], 'functions': [65, 134, 191], 'their': [67, 143], 'counterparts': [68], 'A.': [70, 123, 125, 128, 152, 172, 175, 218], 'annua': [71], 'can': [73], 'convert': [74], 'fed': [75], 'into': [77, 208], 'following': [79], 'products': [80], 'along': [81], 'planta': [86], 'findings': [88], 'suggested': [89], 'a': [90, 166], 'partial': [91], 'artemisinin-producing': [92, 215], 'ability': [93, 216], 'those': [95], 'species.': [96, 117], 'In': [97], 'this': [98, 203], 'study,': [99], 'examined': [101], 'genes': [102], 'highly': [103, 197], 'ADS,': [106], 'first': [108], 'committed': [109], 'gene': [110], 'pathway,': [113], '13': [115], 'We': [118, 130, 145], 'ADS': [120, 139, 149, 200], 'absinthium,': [124], 'kurramensis': [126, 173], 'maritima.': [129], 'analyzed': [131], 'enzymatic': [133], 'all': [136], 'after': [141], 'obtaining': [142], 'cDNA.': [144], 'found': [146, 201], 'homolog': [150], 'from': [151, 171], 'absinthium': [153], 'exhibited': [154], 'novel': [155, 194], 'activity': [156], 'cyclization': [159, 184], 'farnesyl': [161], 'pyrophosphate': [162], '(FPP)': [163], 'koidzumiol,': [165], 'rare': [167], 'natural': [168], 'sesquiterpenoid.': [169], 'Those': [170], 'maritima': [176], 'similar,': [178], 'but': [179], 'novel,': [180], 'activities': [181], 'FPP': [186], '(+)-α-bisabolol.': [188], 'unique': [190], 'sesquiterpene': [195], 'synthases': [196], 'study': [204], 'could': [205], 'provide': [206], 'insight': [207], 'molecular': [210], 'basis': [211], 'exceptional': [214]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2414976871', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 4}, {'year': 2019, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 4}], 'updated_date': '2024-12-13T17:12:49.349046', 'created_date': '2016-06-24'}