Title: Bioequivalent of Levofloxacin Lactate tablets in human
Abstract: Aim:To develop a HPLC-MS method for determination of Levofloxacin Lactate in human plasma and to investigate the pharmacokinetics and bioequivalence of Levofloxacin Lactate tablets . Methods: A randomized crossover desigh was performed in 22healthy volunteers. A single 200mg dose of Levofloxacin Lactate tablets produced by two pharmaceutical co. was administrated to each volunteer. Determin the concentration of Levofloxacin in plasma by HPLC-MS. The main pharmacokinetic parameters of Levofloxacin and the bioequivalence of its two preparations were calculated. Results:The relative bioavailability of the Levofloxacin Lactate tablets was 108.1~123.3%. Conclusion: The assay was shown to be sensitive,accurate and convenient.The two Levofloxacin Lactate tablets were bioequivalent.
Publication Year: 2007
Publication Date: 2007-01-01
Language: en
Type: article
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