Title: Effect of Ailuo Kechuanning on LTB4,IL-6 Levels and Pathological Morphology in Rats with Chronic Obstructive Pulmonary Disease
Abstract: Objective: To study the effect of Ailuo Kechuanning oral liquid on leukotriene B4( LTB4),interleukin-6( IL-6) levels and pathological morphology in plasma and bronchial alveolar lavage fluid( BALF) of rats with chronic obstructive pulmonary disease( COPD). Method: Lipopolysaccharide( LPS) combined with smoke was used to establish COPD rat model; the experimental animals were randomly divided into normal control group,model group, Ailuo Kechuanning oral liquid groups( 5,10,20 g ·kg-1·d-1),enzyme-linked immunosorbent assay( ELISA) was used to determine the change of LTB4,IL-6 levels in rat plasma and BALF in the rats of all groups before and after treatment. Result: The levels of LTB4,IL-6 in plasma and BALF of the model group were significantly higher than those in normal control group; compared with the model group,the levels of LTB4,IL-6 in plasma and BALF of the rats treated with Ailuo Kechuanning oral liquid were significantly decreased. Conclusion: The mechanism of Ailuo Kechuanning oral liquid for treatment of COPD may be related to the inhibition of LTB4,IL-6 release.
Publication Year: 2014
Publication Date: 2014-01-01
Language: en
Type: article
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