Title: Potentiation of anxiolytic effects of diazepam by oryanolum and vitamin B_1
Abstract: Objective:To investigate the anxiolytic effect of compound of diazepam, oryzanolum and vitamin B 1(1∶32∶8,briefly DOV ) and compare its effect with that of diazepam alone.Methods:The elevated plus maze test and pentylenetetrazol discrimination test was adopted.Results:In the elevated plus maze test,the percentage of time that rats and mice for DOV spent in the open arms increased markedly, and was more significant than that of diazepam alone which is equal to the content of diazepam in DOV.In the pentylenetetrazol discrimination test, ED 50 for DOV are 23.4 mg·kg -1 .The content of diazepam is 0.6 mg·kg -1 which is too far less than 3.5 mg·kg -1 for ED 50 of diazepam alone.Conclusion:Oryanolum and vitamin B 1 reinforce anxiolytic effect of diazepam.
Publication Year: 2002
Publication Date: 2002-01-01
Language: en
Type: article
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