Title: Intraoperative frozen-section analysis for papillary thyroid microcarcinoma
Abstract: Objective To investigate the utilization and diagnostic criteria of intraoperative frozen-section analysis in the pathological diagnosis of papillary thyroid microcarcinoma( PTMC),and identify the leading cause of misdiagnosis and missed diagnosis of PTMC. Methods For 36 patients with PTMC confirmed by immunohistochemical technology,the utility of intraoperative frozen section examination was compared with the postoperative routine paraffin section results. Results 28 cases of PTMC were diagnosed by intraoperative frozen section examination,in which 24( 85. 7%) cases were with sclerotic stroma,26( 92. 8%) cases with infiltration,all cases with nuclear atypia,nuclear grooves or intranuclear inclusions. 8 cases were unable to be made a definitive diagnosis,in which 2 cases were negative samples,6 cases were suspicious,misdiagnosis or missed diagnosis,and these cases were mainly the ncapsulated or follicular variant. Conclusion The intraoperative frozen section examination is one of rapid diagnostic methods for PTMC,the main diagnostic criteria include: sclerotic stroma,infiltration,nuclear atypia,nuclear grooves and intranuclear inclusions. The meticulous and normative sampling method and the ability of pathologist to identify the morphological characteristics of ncapsulated and follicular variant can decrease the rate of misdiagnosis and missed diagnosis,and improve the accuracy of intraoperative frozen section examination.
Publication Year: 2014
Publication Date: 2014-01-01
Language: en
Type: article
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