Title: A study of diffusion tensor MR imaging of the corticospinal tract in hemiparetic infants with cerebral palsy
Abstract: Objective:To investigate the value of diffusion tensor imaging(DTI) and fiber tractography(FT) for evaluating the injury of the corticospinal tract(CST) in hemiparetic infants with cerebral palsy(CP).Methods:Twelve hemiparetic infants with CP and 12 age-matched healthy infants underwent routine MRI and DTI.Peabody Developmental Motor Scales 2(PDMS-2) TMQ of all cases were recorded and classified into mild,moderate and severe types by PDMS-2(TMQ).3D tractgraphy of bilateral CST of all patients were created.Fractional anisotropy(FA) values were measured in cerebral peduncle,the posterior limb of internal capsule corona radiate and centrum semiovale.The asymmetric anisotropy index(△FA) between right and left corticospinal tracts was estimated.Results:Compared with the unaffected CST in hemiparetic infants with CP,visual investigation of WM fiber tracts showed that the affected CST were sparsed,compressed,displaced and partial broken.All cases of the affected CST showed a significant FA reduction in all ROIs(P0.01).Compared with the age-matched controls,all patients showed significant asymmetric anisotropy(△FA) in all ROIs(P0.01).Average △FA of CST was correlated negatively with score of TMQ(r=-0.764,P=0.004).Difference between injured classification of CST and the degree of TMQ was statistically significant by Fisher's Exact Test(χ2=6.942,P=0.018).Conclusion:DTI and FT have a high application value in the assessment of the corticospinal tract in hemiparetic infants with cerebral palsy.
Publication Year: 2013
Publication Date: 2013-01-01
Language: en
Type: article
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