Title: The relative bioavailability of Breviscapine sustained-release tablets in Beagle dogs
Abstract: OBJECTIVE To investigate the pharmacokinetics and the relative bioavailability of Breviscapine Sustained-release tablets in animals.METHODS The cross-over design(two periods)was employed.The pharmacokinetics parameters were compared after Beagle dogs were administrated a single dose of the oral Breviscapine Sustained-release tablets and the reference preparation.RESULTS The experimental data were caculated by uring-drug methods.Xu of the reference and the test preparations were 375.925±47.23 μg and 394.592±32.84 μg respechvely.The t 1/2 were 7.197±0.591 h and 12.62±1.207 h,respectively.CONCLUSION Compared with the reference preparation,Breviscapine Sustained-release tablets have the characteristic of sustained-release and are bioequivalent when the tolal absorptivity is taken as the index.
Publication Year: 2004
Publication Date: 2004-01-01
Language: en
Type: article
Access and Citation
Cited By Count: 3
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot