Title: Clinical Effect of Tiopronin in Prevention of Hepatotoxicity Caused by Anti-tumor Agents
Abstract: Objective To explore the clinical effect of tioprpnin in preventing hepatotoxicity induced by anti-tumor agents.Methods Totally 116 inpatients with cancer in Tumor Hospital of Harbin Medical University from March,2004 to August,2008 were randomly divided into tioprpnin group (n=65) and simple chemotherapy group (n=51).The serum levels of alaninc aminotransferase (ALT),aspartate aminotransferase (AST),and total bilirubin (TBIL),and the incidence rate of hepatotoxicity were compared between the two groups.Results The serum levels of ALT,AST,TBIL of tioprpnin group were significantly decreased than those of simple chemotherapy group,and the difference was statistically significant (P0.05).After the treatment,the indexes of liver function of the two groups were both significantly lower than those of the two groups before the treatment,and the difference was statistically significant (P0.05).There were 6 patients appeared liver injury (9.23%) in tioprpnin group,which was significantly less than that of simple chemotherapy group (16/51,31.4%).Conclusions Combination use of anti-tumor drugs and tioprpnin during the chemotherapeutic period could effectively prevent hepatotoxicity induced by anti-tumor drugs.It is worthy of being popularized and applied in clinic.
Publication Year: 2010
Publication Date: 2010-01-01
Language: en
Type: article
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