Title: Study on Relationship of Serum BLyS and APRIL Levels and Systemic Lupus Erythematosus
Abstract: Objective:To determine serum BLyS and APRIL levels of patients with systemic lupus erythematosus(SLE),and investigate the relationship between serum BLyS and APRIL level and SLE disease activity.Methods:To measure serum BLyS and APRIL levels with ELISA in patients with SLE,who were separated into active group(n=13) and remission group(n=10) according to the SLE disease activity index(SLEDAI) and 23 healthy Volunteers and analyze the relationship among serum BLyS and APRIL levels and several clinical items(such as protinuria and anti-dsDNA antibody).Results:Serum BLyS levels in patients with SLE was significantly elevated compared to healthy Controls(P0.05),and active group was higher than remission group(P0.05);The patients with elevated proteinuria had reduced serum APRIL levels(P0.05);The patients with elevated anti-dsDNA antibody had enhanced serum BLyS and APRIL levels,but its was of no statistics significance(P0.05).Conclusion:Serum BLyS levels is positively related to disease activity;The patients with elevated proteinuria have reduced serum APRIL levels(P0.05).BLyS and APRIL may be involved in the pathogenesis of SLE.
Publication Year: 2007
Publication Date: 2007-01-01
Language: en
Type: article
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