Title: COMPARISON OF LANSOPRAZOLE 15 MG AND 30 MG IN THE TREATMENT OF DUODENAL ULCER DISEASE IN CHINA
Abstract: In order to compare the efficacy of lansoprazole 15 mg and 30 mg (TAKEDA) daily in the treatment of duodenal ulcer disease, 109 patients with active duodenal ulcer proven by endoscopy randomized to lansoprazole 15 mg and 30 mg daily for 4 weeks. After 2 weeks complete ulcer healing was seen in 70.6% (36/51) of patients given 15 mg and in 89.7% (52/58) given 30 mg (between-group difference P0.05). At 4 weeks 96.1% (49/51) and 98.3% (57/58) (not significant, P0.05) respectively. The pain relief rate were 55.4% (22/39),82.1%(32/39) and 92.3% (36/39) by day 3,7, and 14 respectively, as compared with 68.8% (33/48), 91.7% (44/48) and 100% (48/48) of patients with lansoprazole 30 mg. Pronounced improvement in the other gastrointestinal symptoms were similar in both groups. Both treatments were equally well tolerated.Conclusion: 15 mg and 30 mg lansoprazole were shown to be highly effective and well-tolerated treatment for active duodenol ulcer disease in China. While the 30 mg lansoprazole showed a more rapid ulcer healing effect.
Publication Year: 1999
Publication Date: 1999-01-01
Language: en
Type: article
Access and Citation
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot