Title: Effects of effective extractive of Longteng Capsule on inflammation and immune reaction in rats
Abstract: AIM: To study the therapeutic effects of the effective extractive of Longteng Capsule on inflammation and immune reaction in rats.METHODS: Three types of inflammatory animal models were used: acute inflammatory edema of paws,Freund's adjuvant arthritis and chronic granuloma.T cell subpopulation in rats was measured by flow cytometry.ELISA assays were performed to determine serum IL-1β and IL-2.RESULTS: The extractive inhibited the edema of inflammatory tissue,relieved adjuvant arthritis and inhibited chronic granuloma.Arthritis score was(4.1±0.3) on 27 d.The serum IL-1β and IL-2 levels were significantly reduced to(60±6) and(175±90) μg/kg.CONCLUSION: The extractive of Longteng Capsule has some immunosuppressive and anti-inflammatory effects on the experimental models used in our study,possibly by reducing the release of cytokines such as IL-1β and other inflammatory mediators.
Publication Year: 2005
Publication Date: 2005-01-01
Language: en
Type: article
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