Title: The Efficacy and Safety of Amiodarone Combined With Metoprolol on Nonvalvular Atrial Fibrillation
Abstract: To observe the efficacy and safety of amiodarone combine with metoprolol on nonvalvular atrial fibrillation (AF),49 patients with coronary artery disease accompanying AF were divided into group A (25 cases)and group B(24 cases) according to wether the routine oral metoprolol was performed before admittance.Intravenous loading dose of 3~5 mg/kg of amiodarone was given within 10 min,followed by 600 μg/min infusion for 48 hours in group A and group B,and group B was combined with oral metoprolol of 12.5~50 mg/d.Result:83.3%(20/24) patients with AF restored to normal sinus rhythm in group B and 76%(19/25) sinus rhythm was obtained in group A.There was no significant difference in restoration rates during 48 hours between group A and group B,but dose of amiodarone was lower,restoration duration was shorter,the rhythm after restoration was slower in group A than group B(576.4±331.9 mg vs 880.2±395.3 mg ,9.4±9.2 h vs 17.2±10.6 h,76.8±17.9 bpm vs 86.3±18.2 bpm,respectively,all P 0.05).The side effect for group A and group B were 8.0% and 8.3% respectively.Concusion:Amiodarone combined with metoprolol is effective and safe for treatment of nonvalvular AF and shows a shorter restoration duration and a lower dose of amiodarone.
Publication Year: 2003
Publication Date: 2003-01-01
Language: en
Type: article
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