Title: Effect of p38MAPK inhibitor pretreatment on cytokins in serum and bronchoalveolar larage fluid in rats with acute lung injury
Abstract: Objective To investigate the mechanism of therapeutic effect of p38MAPK inhibitor on acute lung injury(ALI).Methods ALI model of rats was established by injecting lipopolysaccharide(LPS)to the abdominal cavity and trachea and ELISA assay was used for detecting the levels of TNF-α,IL-6 and IL-10 in serum and bronchoalveolar larage fluid(BALF).Results The levels of TNF-α,IL-6 in serum and BALF in experiment and pretreatment groups were significantly higher than those in control group(P0.01),which in the expriment group were significantly higher than those in the pretreatment group(P0.05).The level of IL-10 in serum and BALF in the experiment and pretreatment groups were significantly higher than those in the control group(P0.01),which were not remarkably different between the experiment group and pretreatment group.Conclusions TNF-α,IL-6 and IL-10 may play important roles in the process of LPS-induced ALI in rats.p38MAPK inhibitor may relieve lung injuries by inhibiting excessive discharging of TNF-α and IL-6.
Publication Year: 2008
Publication Date: 2008-01-01
Language: en
Type: article
Access and Citation
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot