Title: Diffusion Tensor Imaging Analysis with Tract-Based Spatial Statistics in Patients with Mesial Temporal Lobe Epilepsy
Abstract: Magnetic resonance diffusion tensor imaging(DTI) data were analyzed in this study,and the white matter abnormalities in patients with mesial temporal lobe epilepsy were observed using tract-based spatial statistics(TBSS).46 mTLE patients(24 with left hippocampal sclerosis(LHS) and 22 with right hippocampal sclerosis(RHS)) and 42 age-and gender-matched healthy volunteers were involved in the study.Voxel-wise group comparison of white matter fractional anisotropy(FA) was performed using TBSS.FA reduced with LHS patients showed a bilateral distribution,slightly to the affected side,including the corpus callosum,superior and inferior longitudinal fasciculus,anterior limb of internal capsule,etc.In addition,the interior fronto-occipital fasciculus and the cingulate bundle were only found a significant reduction in the left halves of the brain.RHS groups had significantly lower fractional anisotropy which was localized to the right brain,including the corpus callosum,superior and inferior longitudinal fasciculus,uncinate fasciculus,etc.Diffusion tensor imaging analysis with TBSS reflected white matter changes in mTLE with HS.These results contributed to understand the physiopathologic mechanism of mTLE.
Publication Year: 2012
Publication Date: 2012-01-01
Language: en
Type: article
Indexed In: ['crossref']
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