Title: Protective Effect of Lactobacillus acidophilus Synbiotics on Gastric Mucosal Damage Induced by Nonsteroidal Anti-inflammatory Drugs in Rats
Abstract: Background: Gastric mucosal damage caused by nonsteroidal anti-inflammatory drugs (NSAID) is the most common medicine-related adverse effect. How to prevent and cure it is an important problem. Aims: To investigate the protective effect of synbiotics formed by combination of Lactobacillus acidophilus (L. acidophilus) and iso-malto-oligosaccharide on NSAID-induced gastric mucosal damage in rats. Methods: Eighty Sprague-Dawley rats were randomly allocated to high-, medium- and low-dose experimental groups, model control group and normal control group. L. acidophilus synbiotics in different concentrations was administered orally to experimental rats for 30 days, the model control rats were administered saline simultaneously. Then indomethacin was used to induce gastric mucosal damage and ulcer. The ulcer index (UI) and histopathological changes of gastric mucosa were analyzed. Results: The gastric mucosal damage in rats protected with different concentrations of synbiotics was less than that in the model controls, mucosal hyperemia was mild, the UI was decreased significantly (P0.05), and the histopathological lesions were remarkably improved. Conclusions: The L. acidophilus synbiotics can decrease the gastric mucosal damage induced by NSAID in rats through its protective effect on gastric mucosa.
Publication Year: 2006
Publication Date: 2006-01-01
Language: en
Type: article
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