Title: Analysis the pharmacokinetics of docetaxel niosomes in rats
Abstract: Objective To study the pharmacokinetics of docetaxel niosomes in rats.Methods Docetaxel concentration in plasma was assayed by HPLC with Diamosil C18 column(250 mm×46 mm,5 μm),methanol-water(72/28,V/V),and detection wavelength of 230nm.The pharmacokinetic parameters were researched after single injection of docetaxel niosomes and injection in 7 rats,respectively.Result The linear range for docetaxel in rat plasma was 1.0~20.0μg/ml(r = 0.9982,n = 6).It also has a high recover rate and a low RSD.Conclusion This method is simple,accurate,sensitive for measurement of concentration of docetaxel in plasma of rats.Niosomes prepared with docetaxel had significantly different distribution and elimination in vivo.Compared with docetaxel injection had a much lower elimination rate,and higher AUC in rats.
Publication Year: 2009
Publication Date: 2009-01-01
Language: en
Type: article
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