Title: Clinical Study on the Treatment of Osteoarthritis with Sustained-released Tablet of Aceclofenac
Abstract: Objective: To assess the efficacy and safety of sustained-released tablet of aceclofenac versus aceclofenac tablet in the treatment of osteoarthritis(OA). Methods: Randomized, double-blind, double-simulated, paralleled, and controlled clinical trial was performed. 42 patients were divided into sustained-released tablet of aceclofenac group(n=21) and aceclofenac tablet group(n=21). They were given sustained-released tablet of aceclofenac 200 mg daily or aceclofenac tablets 100 mg twice a day for 4 weeks, respectively. Results: After the treatment of 2 and 4 weeks, the total efficacy rates of sustained-released tablet of aceclofenac group were 52.38% and 80.95%, while those of aceclofenac tablet group were 42.86% and 61.90%, respectively (P0.05). Both drugs could improve the symptoms and signs of OA(P0.05). The incidence of adverse effects of sustained-released tablet of aceclofenac was 14.29%; and that of aceclofenac tablet was 9.52% (P0.05). The main adverse events of sustained-released tablet of aceclofenac were slight gastrointestinal symptoms. Conclusion: Sustained-released tablet of aceclofenac is a safe, and effective drug, as same as aceclofenac tablet, and also a more convenient drug in treating OA.
Publication Year: 2007
Publication Date: 2007-01-01
Language: en
Type: article
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