Title: Acute Irradiation-Induced Hepatitis in Rabbits: Feridex-Enhanced MRI Evaluation
Abstract: Objective To evaluate the diagnostic capability of Feridex (SPIO)-enhanced MRI at the early stage of acute irradiation-induced hepatitis. Methods Five rabbits were carried on MRI T2WI conventional and Feridex contrast-enhanced scan consequently on the third day of post-irradiation. The images were also compared with histopathologic findings. Results On plain-scanned images the signal intensity (SI) of the liver showed no abnormality, but on Feridex-enhanced MR images, livers' SI of irradiated regions were higher than non-irradiated area with delineating line between them. In microscopic study, both irradiated and non-irradiated regions showed no evidence of inflammatory cell infiltration, congestion, edema or fibrosis. Conclusion Feridex-enhanced MRI on the third day post-irradiation could detect abnormal changes of irradiation-induced hepatitis when no histopathologic changes in light microscope, and it has great value in acute irradiation-induced hepatitis diagnosis, especially at the very early stage.
Publication Year: 2003
Publication Date: 2003-01-01
Language: en
Type: article
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