Title: Pharmacokinetics and relative bioavailability of indapamide controlled release tablets in Beagle dogs
Abstract: Objective:To study the pharmacokinetics and relative bioavailability of indapamide controlled release tablets in healthy Beagle dogs.Methods:Indapamide controlled release tablets(test product) and indapamide sustained release tablets(reference product) were given orally to six healthy Beagle dogs by a two-crossover design.Indapamide concentrations in plasma were determined by HPLC-MS and the plasma concentration-time curves were plotted.The pharmacokinetic parameters and relative bioavailability were calculated and evaluated using statistic computer program.Results:The concentration-time curve of indapamide controlled release tablets was similar to that of indapamide sustained release tablets,and their t1/2 were(11.71±1.69) and(11.87±1.72) h,Cmax were(87.17±22.03) and(87.64±24.24) μg·L-1,Tmax were(6.67±0.52) and(6.83±0.75) h,AUC0~48 h were(1 200.31±577.16) and(1 162.53±463.85) μg·h·L-1,AUC0~∞ were(1 276.73±619.22) and(1 250.20±507.63) μg·h·L-1,respectively.According to AUC0~48 h,the relative bioavailability of indapamide controlled release tablets was(101.0±17.7)%.Conclusion:Compared with the sustained release tablets,indapamide controlled release tablets have similar pharmacokinetic profile and bioavailability.
Publication Year: 2010
Publication Date: 2010-01-01
Language: en
Type: article
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