Title: Clinical Significance of Detection of Serum Soluble Intercellular Adhesion Molecule-1 in Patients with Lung Cancer
Abstract: Purpose]To assess the relationship between the dynamic changes of serum level soluble intercellular adhesion molecule-1(sICAM-1) and the effect of intravenous chemotherapy in patients with lung cancer, and to investigate the serum levels of sICAM-1 after radical surgery in lung cancer patients. [Methods] Forty cases with advanced or recurrent lung cancer(palliative chemotherapy group) received chemotherapy. Serum sICAM-1 levels were measured by enzyme-linked immunosorbent assay before chemotherapy and after 1, 2 cycle of chemotherapy. The relationship between the serum levels of sICAM-1 before and after chemotherapy, and the effects of chemotherapy in 23 cases who had no prior chemotherapy were analysed. The serum levels of sICAM-1 in 21 lung cancer patients after radical excision and meanwhile 27 healthy controls were measured as control. [Results] The serum levels of sICAM-1 in the palliative chemotherapy group (526.6ng/ml±213.9ng/ml) were significantly higher than those in the healthy control group (281.3ng/ml±109.8ng/ml, P0.001). In the patients who had no prior chemotherapy and were effective after chemotherapy, the serum level of sICAM-1 decreased after 1 cycle (P0.05) and markedly dripped down after 2 cycles (P0.01), but no significant change after cycle 1 (P0.05) and marked increase after 2 cycle(P0.05) was found in no response cases. The serum sICAM-1 level in the postoperative cases (380ng/ml±140.9ng/ml) were significantly higher than that in the healthy controls (P0.01) and lower than that in the palliative chemotherapy group(P0.01).[Conclusion]Serum levels of sICAM-1 is possible to become a marker to evaluate efficacy of chemotherapy and to detect recurrence for lung cancer patients.
Publication Year: 2005
Publication Date: 2005-01-01
Language: en
Type: article
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