Title: Relative bioavailability of cefixime orally disintegrating tablets
Abstract: Objective To determine the relative bioavailability of cefixime orally disintegrating tablets and capsules and to evaluate their bioequivalence.Methods According to the crossover design,each volunteer was given a single oral dose of 200 mg cefixime orally disintegrating tablets or capsules.The plasma was obtained and determined by HPLC-UV.Results The pharmacokinetic parameters of cefixime orally disintegrating tablets and capsules in the plasma were as follows:Cmax was(2.922±1.161)and(2.725±1.042)mg·L-1;tmax was(3.42±0.94)and(3.50±0.61)h;AUC0~t was(21.32±9.87)and(19.54±9.51)mg·h·L-1;t1/2 was(3.68±1.69)and(3.86±1.73)h.The relative bioavailability of the two preparations was(110.2%±12.7 %).Conclusion The two cefixime preparations were bioequivalent.
Publication Year: 2009
Publication Date: 2009-01-01
Language: en
Type: article
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