Title: Follow-up observation on curative effects of single drug or plus treatment with topiramate for different type epilepsy
Abstract: Objective Investigate the long term clinical curative effects of single drug or plus drug treatment with topiramate for different type epilepsy.Methods 95 patients with epilepsy were treated with topiramate in single or plus drug.After 6 months,one year,tow years,the rate of control,rate of retain,and the adverse events were investigated on the patients.Results When admited 6 months,the rate of control in the patients with SPS(58.8%) and GTCS(52.8%) were higher than those of the other suize type,the rate of control in the single drug group(63.8%) was significantly higher than that of plus drug group(27.0%).The rate of retain in the single drug group at one year(68.5%) and 2 years(62.1%) were significantly higher than those of plus drug group(56.8%,40.5%).The advers events of this group patients were anorexia,emaciate,no sweatting,gawky,numbnerss,forgetfulness,attention no focusing.Conclusion There are significant curative effects with topiramate for all types of epileps.Those of SPS and GTCS are the most significant,their rates of control in short and long term are higher.
Publication Year: 2009
Publication Date: 2009-01-01
Language: en
Type: article
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