Title: Safety and efficacy of different ways of amiodarone administration for treatment of paroxysmal atrial fibrillation
Abstract: Objective To investigate the safety and efficacy of different ways of amiodarone administration for treatment of paroxysmal atrial fibrillation(AF).Methods The study population consisted of 128 patients with paroxysmal AF,which was divided as group A:5 mg/kg over 15 min followed by 1.5 mg/min over the next 6 h,by 0.7~1 mg/min over 24~48 h,at the same time oral amiodarone 200 mg per day and group B:oral amiodarone 600 mg per day.The ECG and blood pressure of all patients were monitored for 48 h.Results Conversion rate of AF was no differences(P0.05).Mean time of cardioversion was 734±128 min in group A and was 1 428±242 min in group B(P0.05).The heart rate of remaining AF was significantly decreased after treatment 7 days and 1 month(P0.05).However,blood pressure(BP)in group B remained stable for the observation period,whereas it fell significantly in group A.5 patients in group A developed superficial phlebitis.Conclusion Intravenous amiodarone acts quicker than its oral form,but increases the risk of hypotension and superficial phlebitis.
Publication Year: 2008
Publication Date: 2008-01-01
Language: en
Type: article
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