Title: Bioavailability of nimodipine tablet In healthy volunteers
Abstract: Objective:The pharmacokinetics and relative bioavailability of oral nimodipine tablet were studied in healthy volunteers. Methods: A single 120mg oral dose of nimodipine and nimotop were given to 8 healthy male volunteers in a randomized crossover study ,the drug concentrations in plasma were determined by HPLC.Results: The plasma concentration time curves of nimodipine and nimotop were fitted to the one compartment opened model with first-order absorption. The main pharmacokinetic parameters were:Tmax (0.90±0.28)h and (1.07± 0.16) h, Cmax (61.5±32.0) ng/ml and (39.7±10.1) ng/ml, AUC (151.7±61.2) ng h/ml and(160.7±59.3)ng h/ml for nimodipine and nimotop tablets respectively. The pharmacokinetic parameters obtained from the studies showed no significant difference between the two tablets(P0.05).Conclusion: The relative bioavailability of nimodipine tablet was (93.77%±11.62%)compared with nimotop tablet, the results of statistical analysis showed that these two drugs were biologically equivalent.
Publication Year: 2002
Publication Date: 2002-01-01
Language: en
Type: article
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