Title: Study of porcine cerebral venous sinus thrombosis model established by transvenous method
Abstract: Objective To explore the way of establishing porcine cerebral venous sinus thrombosis model by injection of thrombin via percutaneous transvenous method. Methods Six mini-pigs were performed percutaneous transvenous catheterization by Seldinger technique,and thrombin was injected into the cerebral venous sinus to induce thrombosis,which was then confirmed by digital subtraction angiography(DSA) immediately and 1 week later.MRI examinations were performed 1,3 and 7 days after the procedure,and the pigs were sacrificed for gross and histological examinations.Results The models of cerebral venous sinus thrombosis were successfully established in all the pigs,including 3 cases in superior sagittal sinus,2 cases in superior sagittal sinus accompanied with left transverse sinus and sigmoid sinus and 1 case in left transverse sinus and sigmoid sinus.Cerebral edema was observed in 4 pigs by MRI at the first day of follow-up,and cerebral infarction in 2 cases at the third day of follow-up,among which hemorrhagic infarction in 1 case.Cerebral edema was significantly released after 7 days of follow-up in 5 cases,and edge of cerebral infarction area became clear in 2 cases. Conclusion The method of inducing porcine cerebral venous sinus thrombosis by injection of thrombin via percutaneous transvenous catheterization is feasibile and efficient,which is more similar to the pathogenesis and disease coures of actual conditions than the former ones.
Publication Year: 2008
Publication Date: 2008-01-01
Language: en
Type: article
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