Title: Effect of Aima oral liquid on airway inflammation in rats with chronic bronchitis
Abstract: ObjectiveTo study the effects of Aima oral liquid(AM) on the airway inflammation in rats with chronic bronchitis(CB) and to study the therapeutic mechanism of AM.Method Rat model with CB was established by intratracheal injection with low dose of lipopolysaccharide.Male Wistar rats were randomly divided into four groups,sham operated(Sham) group,CB group,CB+AM group,and CB+Juhongzhike oral liquid(JH) group,with 7rats in every group.The total number of WBC and differential count in the bronchoalveolar lavage fluid(BALF) were counted.The activity of MPO in the lung,the activity of total SOD in BALF,lung and blood plasma,the MDA content in the lung and blood plasma,and the content of IL-8 and TNF-α in BALF,lung and blood plasma were measured.Results The number of total cells,monocyte-macrophage,neutrophil and lymphocyte were significantly increased in the BALF of model group compared with sham group(P0.01).After treated by AM,the number of total cell and the and differential count WBC in the BALF were significantly decreased compared with CB rats(P0.05).The activity of total SOD decreased significantly in BALF,lung and blood plasma,and the content of MDA was increased significantly in BALF and lung in the CB rats(P0.01);The activity was increased significantly and the content of MDA in CB+AM group(P0.05).Farther study showed that AM could significantly decreased the content of IL-8 in the BALF compared with CB model group,significantly decreased the content of TNF-αcompared with CB model group,not only in the BALF,but also in the lung and blood plasma.Conclusion AM can reduce the airway inflammation of the CB rats through down regulating the secreting of TNFα and IL-8,and promoting the clearance of the oxygen free radical and increasing the ability to resist the lipoperoxidation injury.
Publication Year: 2007
Publication Date: 2007-01-01
Language: en
Type: article
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