Title: A study of antipyretic effect of ChaiHuang Keli with different doses on children with acute upper respiratorytract infection
Abstract: Objective To Find the best dose of ChaiHuang Keli in clinical treatment of children with acute upper respiratory infection. Methods Clinical randomized controlled trial was carried out for this research.Totally 200 patients were chosen based on the inclusion criteria , and they were divided into five groups:positive control group , high , middle , and low dose of ChaiHuang Keli treatment group and placebo group.The patients were divided by age into three levels: below three years old , between 3 and 5 , and beyond six ; different treatments were given respectively as designed.The control group ( Kanggan Keli , 10 g each time , three times a day , tid ); treatment group A ( ChaiHuang Keli , 6-10g , tid ); placebo group ( placebo , 10 g , tid ) .All patients had the same three-day course of treatment and the effects were compared among the groups. Results Effect ratio ( FAS ) of the control group , three treatment groups and placebo group were re spectively 98.00% , 93.17% , 97.37% , 73.68% and 40.54%.According to the comparison among groups , the effect of group B was nearly the same as group A and the positive control group , while it was better than group C ; all treatment groups had quite statistical significance compared with the placebo group in this research.There was no significance among group A 、 B and C (P 0.05 ), but there was statistical significance between treatment group and the placebo group (P 0.05 ) .The statistical result t of FAS and PPS analysis was nearly the same.No adverse effects were observed in this research. Conclusion The middle dose group of ChaiHuang Keli in this research shows the best effect in curing children with acute upper respiratory infection ( wind-heat syndrome ), and can be recommended in clinical areas.
Publication Year: 2012
Publication Date: 2012-01-01
Language: en
Type: article
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