Title: Pharmacokinetics and bioequivalence of deferiprone extended-release tablets in Beagle dogs
Abstract: AIM To establish a HPLC method for the evaluation of bioavailability and pharmacokinetic studies of deferiprone in Beagle dogs.METHODS A random two-way crossover study in 6 dogs was adopted.The drug serum con- centration was determined by internal standard HPLC method.The pharmacokinetic parameters were calculated by mo- ment method.RESULTS The results indicated that the t_(max) and MRT of extended-release tablets (ER) were longer than those of immediate-release tablets (IR)(P0.05),and theρ_(max) of ER was lower than that of IR(P0.01).The bioavailability of ER relative to IR was (99.06±7.10)%.CONCLUSION The method is proved to be simple,sensi- tive and rapid.The two formulations have the same absorption extent.Comparing with IR,the ER exhibits good extended release tendency.
Publication Year: 2008
Publication Date: 2008-01-01
Language: en
Type: article
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Cited By Count: 1
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