Title: Preoperative evaluation of tumor grade in gliomas using diffusion tensor imaging
Abstract: Objective:To prospectively evaluate whether diffusion-tensor magnetic resonance(MR) imaging(DTI) depicts differences in low-grade gliomas(WHO grade Ⅰ and Ⅱ) and high-grade gliomas(WHO grade Ⅲ and Ⅳ) on the basis of measuring FA value of the tumor.Methods:Diffusion-tensor MR imaging was preoperatively performed in 45 patients(25 men,20 women;mean age,43 years) with histologically confirmed brain gliomas.19 of the 45 tumors were low-grade gliomas(WHO grade Ⅰ or Ⅱ) and 26 were high-grade gliomas(WHO grade Ⅲ or Ⅳ).Regions of interest were placed in the tumor center.Fractional anisotropy(FA) ratios were calculated for regions of interest in relation to the NAWM of the contralateral frontal lobe and occipital lobe.Results:Median FA ratios for NAWM of the contralateral frontal lobe and occipital lobe were 0.40±0.02 and 0.31±0.04 respectively,for low-grade versus high-grade gliomas,were 0.12±0.03 versus 0.24±0.05,respectively.Differences in FA ratio between low-grade and high-grade tumors were significant(P0.05).Differences in FA ratio were significant between low-grade or high-grade gliomas and NAWM of the contralateral frontal lobe or occipital lobe.Conclusion:The FA value of gliomas is lower than NAWM of the contralateral hemisphere,and FA value of low-grade glioma is lower than high-grade gliomas.FA value in some degree reflects the histological structure of the brain tumor and DTI is helpful in discriminating low-grade from high-grade gliomas.
Publication Year: 2008
Publication Date: 2008-01-01
Language: en
Type: article
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