Title: Pharmacokinetics and relative bioavailability of cefixime capsules in healthy volunteers
Abstract: Objective: To study the pharmacokinetics and bioequivalence of cefixime capsules in healthy human.Methods:A single oral dose of 400 mg cefixime was given to 18 healthy volunteers in a randomized,cross-over study.Serum concentrations of cefixime were determined by HPLC method.Results:The main pharmacokinetic parameters of the reference and test capsules were as follows: tmax(3.39±0.50) and(3.39±0.50) h,cmax(2.33±0.33) and(2.27±0.25) μg/mL,t1/2(3.92±0.85) and(4.41±0.68) h,AUC 0-16(14.61 ±2.67) and(14.82 ±2.02) μg·h·mL-1,AUC0-∞(16.00±3.13) and(16.81±2.62) μg·h·mL-1.Conclusion:The two formulations were bioequivalent.The relative bioavailability of test capsules is(98.69±13.13)%.
Publication Year: 2008
Publication Date: 2008-01-01
Language: en
Type: article
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