Title: Pharmacokinetics of meptazinol hydrochloride injection in healthy volunteers
Abstract: Objective To evaluate the pharmacokinetics of meptazinol hydrochloride injection in Chinese healthy volunteers.Methods Thirty-six healthy volunteers were devided into three groups.Two groups received a single dose of 25 mg and 50 mg meptazinol hydrochloride intravenously,the other group received a single dose of 75 mg meptazinol hydrochloride intramuscularly.Concentrations of meptazinol in plasma were determined by HPLC-MS/MS.The pharmacokinetic parameters were calculated by DAS 2.0 software.Results The main pharmacokinetic parameters of three groups were as follows: AUC0-t were(241.50±50.25),(621.72±208.10) and(898.16±194.29) ng·h·mL-1;AUC0-∞ were(247.79±51.98),(636.10±213.05) and(921.14±214.86) ng·h·mL-1;Cmax were(203.58±38.61),(393.98±66.92) and(347.64±72.94) ng·mL-1;tmax were(0.05±0.02),(0.05±0.02) and(0.56±0.33) h;t1/2 were(2.24±0.85),(2.19±0.66) and(2.18±0.42) h,respectively.There were no significant difference of AUC0-∞,Cmax,t1/2z,CLz,Vz in two groups(intravenous groups) by analysis of variance.The relative bioavailability of 75 mg intramuscularly to 50mg intravenously was 96.54%.Conclusion The pharmacokinetic parameters such as AUC0-t,AUC0-∞,Cmax directly propotion to doses of 25~50 mg intravenously in human body.
Publication Year: 2011
Publication Date: 2011-01-01
Language: en
Type: article
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