Title: Cost-effectiveness analysis on Trimebutine Maleate combined with hydrotalcid in treatment of bile reflux gastritis
Abstract: Objective To select the drugs which can treat bile-reflux gastritis to be safe、effective and economical.Method Ninety-four patients with BRG who proved by gastroscopy and pathology were randomized divided into group I(Trimebutine Maleate combined with hydrotalcid;44 cases)and II(Itopride Hydrochloride combined with hydrotalcid;50 cases).Symptoms including abdominal pain、abdominal distension、gas、retrosternal pain or heartburn and nausea or vomiting were investigated about 4 weeks before and after treatment.Gastroscopy and blood test were also reexamined.Results Total effective rate of I group was about 89%,II group was 88%,adverse reaction rate in I and II group was not statistically significant(P0.05).C/E ratio of I group was 2.41,C/E ratio of II group was 3.60;from △C/△E we can see,if II group wanted another 1 unit-effect,85.97 Yuan should be paid.Sensitivity analysis results:C/E ratio of I group was 2.17,C/E ratio of II group was 3.24;from △C/△E we could see,if II group wanted another 1 unit-effect,86.05 Yuan should be paid.The reliability of the primary results was confirmed.Conclusion Using Trimebutine Maleate combined with hydrotalcid to treat BRG has more efficacy and saving than Itopride Hydrochloride combined with hydrotalcid.This is worth to recommend in clinical.
Publication Year: 2013
Publication Date: 2013-01-01
Language: en
Type: article
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