Title: Effect of Yanhuning Injection on animal models with acute pharyngitis and its mechanism
Abstract: Objective To explore the effects of Yanhuning Injection in rat models with acute pharyngitis and its mechanisms based on an experimental study.Methods The rats were used in this study to establish the model of acute pharyngitis induced by directly applying beta hemolytic streptococcus into pharyngeal mucosa at first.Then,the several groups were treated by Yanhuning Injection for 5 d.The expression of serum IL-1β,IL-6β and TNF-α were evaluated by enzyme-linked immunosorbent assay(ELISA) and the effects on pathologic morphology were observed.Results In Yanhuning groups with high-and mid-doses,the expression of serum IL-1β,IL-6β could be obviously inhibited and the pathological changes of model group with acute pharyngistis improved in different degrees;In Yanhuning high-dose group,the expression level of TNF-α could be inhibited.Conclusion It indicates that Yanhuning Injection has a good curative effect on acute pharyngitis.The therapeutic mechanisms of Yanhuning Injiection may be related to the regulation on the expression of cytokines and the inhibition on the pathological changes of pharynx.
Publication Year: 2012
Publication Date: 2012-01-01
Language: en
Type: article
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Cited By Count: 1
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