Title: Detection of radiation brain injury of malignant glioma by 1 H-MRS
Abstract: Objective Using proton magnetic resonance spectroscopy(1H-MRS) method,to evaluate the difference of radiation brain injury between volumetric modulated arc therapy(VMAT) and three-dimensional conformal radiation therapy(3DCRT) in patients with postoperative glioma after radiation therapy.Methods 24 patients with malignant glioma(WHOⅡ-Ⅳ grade glioma) confirmed with clinical surgery were selected,among them 12 patients were treated with VMAT technique,and another 12 patients with 3DCRT technique,all received DT60-66GY/30-33F dose prescriptions.1H-MRS examination was performed to analyze the change of metabolites in the brain tissues of region of interest(ROI) before and after radiotherapy,and the ratios of NAA/ Cr,Cho / Cr,NAA / Cho were computed.Results The dose distribution of VMAT group was superior to 3DCRT group,the NAA/Cr in two groups after radiation were decreased compared with before radiation,there was a statistically difference in NAA/Cr after radiation between two groups(P0.01).The Cho / Cr and NAA / Cho in two groups were increased compared with before radiation;after radiation,only NAA/Cho had a statistical difference between two groups(P0.01).Conclusion VMAT technique is superior to 3DCTR to reduce radiation brain injury in patients with postoperative glioma.
Publication Year: 2011
Publication Date: 2011-01-01
Language: en
Type: article
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Cited By Count: 1
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