Title: Efficacy and Safety of Oxcarbazepine Combined with Other Anti-Epileptic Drugs in Treatment of Epilepsy in Children
Abstract: Objective To explore the efficiency,dosage and safety of Oxcarbazepine(OXC) combined with other anti-epileptic drugs in treatment of epilepsy in children. Methods The study included 41 patients with epilepsy(23 male and 18 female),with a mean age of(7.70±3.25) years old(ranging from 6 months to 15 years old).Their epileptic history varies from 15 days to 5 years,with average of(9±17) months,and they were followed up for 6 months to 6 years,average of(2.5±1.6) years.The seizures were classified as simple partial seizure(SPS) in 3 cases,complex partial seizure(CPS) in 8/41 cases,secondary generalized tonic-clonic seizure(sGTCS) in 14/41 cases,SPS combined with sGTCS in 12 cases,and CPS combined with sGTCS in 4 cases.The clinical data of 41 patients with epilepsy were analyzed retrospectively and their efficiency and safety were evaluated.According to sequence of treatment with additional OXC,all the patients were divided into 2 groups(group A and group B).Patients in group A were treated with adding on OXC since their seizures were not controlled by other anti-epileptic drugs,patients in group B treated with OXC,added with other anti-epileptic drugs owing to the poor effect. Results In group A,the percentage of seizure free after adding OXC was 48.3%,while the general effective rate which the seizures frequency decreased above or equal 50% was 82.7%,the dosage of OXC was(26.70±6.75) mg·kg-1·d-1.Among group A,12 patients were successfully transformed to OXC monotherapy,and 10 patients achieved seizure free.The treatment of OXC added with a low dose of nitrazepam achieved of the highest effective rate in group B.The effective rate was all above or equal to 50% for the every type of partial seizures.The side effects of OXC were found in 8 patients,including drowsiness in 3 cases,skin rash in 2 cases,blurred vision,hyponatremia without symptom and ache of knee joint in 1 case respectively.These symptoms were relieved after increasing dosage slowly,decreasing dosage or receiving no treatment. Conclusion OXC as a combined anti-epileptic drugs therapy is effective in treatment of epilepsy and had high safety and low resistance,and it′s one of the new anti-epileptic drugs which is fit for application in long-term.
Publication Year: 2011
Publication Date: 2011-01-01
Language: en
Type: article
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