Title: Pharmacokinetics of domestic cetirizine hydrochloride chewable tablets in healthy volunteers
Abstract: OBJECTIVE To study the pharmacokinetics of cetirizine hydrochloride chewable tablets in Chinese healthy volunteers. METHODS 18healthy male volunteers received a single 10mg oral dose of cetiriszine hydrochloride chewable tablets. The plasma concentrations of cetirizine was determined by an improved LC/MS method. Data of plasma level-time were disposed with PKS software. RESULTS The main pharmacokinetics parameters of cetirizine were as follows:Cmax was(25. 21±24. 35)μg·L-1,Tmax was (1. 6±0. 3)h, ,T1/2was (9. 4±3. 6)h,,AUC0-36(1594. 3±362. 6)μg·L-1·h,,AUC0-∞was(1688. 0±498. 6)μg·L-1·h. CONCLUSION The study will offer useful reference for the clinical application.
Publication Year: 2007
Publication Date: 2007-01-01
Language: en
Type: article
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