Title: Study on bioequivalence of domestic and imported cefpodoxime proxetil tablets
Abstract: Objective:To study the bioequivalence of domestic and imported cefpodoxime proxetil (CPDX-PR) tablets.Methods:A single dose of 200mg domestic and imported CPDX-PR tablets were given to 24 male healthy volunteers in a randomized two way crossover design.The cefpodoxime level in serum were determined by RP HPLC and data obtained were analyzed by 3P97 program.Results:The T max , C max ,AUC 0-t of domestic and imported tablets were (2.27±0.49) and (2.50± 0.61)h, (3.64±0.53) and (3.48±0.57) mg·L -1 ,(18.12±2.79) and (17.95±3.07)mg·h·L -1 ,respectively.The relative bioavailability of domestic tablets was (102.31±15.40)%.Conclusion:The domestic and imported CPDX-PR tablets were bioequivalent.
Publication Year: 2002
Publication Date: 2002-01-01
Language: en
Type: article
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