Title: Curative Effect of Quadruple Chemotherapy in Treating Helicobacter Pylori-positive Duodenal Bulbar Ulcer
Abstract: Objective To observe the effects of the quadruple chemotherapy including rabeprazole on Helicobacter pylori(Hp) and on Hp-positive duodenal bulbar ulcer.Methods One hundred and twenty patients with Hp-positive duodenal bulbar ulcer were randomized into groups therapy and control,60 in each.Therapy group received oral rabeprazole(10 mg/times),ranitidine bismuth citrate(RBC,350 mg/times),amoxicillin(1 000 mg/times),furazolidone(100 mg/times),twice/d,4 d altogether.Control group received oral omeprazole(20 mg/times),amoxicillin(1 000 mg/times),clarithromycin(500 mg/times),twice/d,7 d altogether.After anti-Hp treatment,rabeprazole(10 mg/times) or omeprazol(20 mg/times) was continuously used,once/d,2 weeks.The Hp eradication rate and ulcer healing rate 4~6 weeks after treatment,and ulcer relapse rate and Hp reinfection after six-month or 1-year follow up were observed.Results The ulcer healing rates of groups therapy and control were 98.2%,93.1%,respectively,4~6 weeks after treatment,the difference was not significant(P0.05),and the Hp eradication rates were 96.4%,77.6%,respectively,the difference was significant(P0.01).The ulcer relapse rates were 3.8%,15.7%,respectively,after 6-month follow up,and 5.9%,20.0%,respectively,after 12-month follow up,the difference was significant(P0.05).Hp re-infection rates were 7.5%,21.6%,respectively,after 6-month follow up,and 11.8%,28.0%,respectively,after 12-month follow up,the difference was significant(P0.05).Conclusion The 4-day quadruple chemotherapy of combined rabeprazole and RBC is a short-range,efficient and safe method in Hp eradication and ulcer healing promotion.
Publication Year: 2010
Publication Date: 2010-01-01
Language: en
Type: article
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