Publication Information

{'id': 'https://openalex.org/W2354175014', 'doi': None, 'title': 'Study on the Relationship between P13K/Akt Signal Transduction Pathway and Cisplatin Resistance in Ovarian Carcinoma', 'display_name': 'Study on the Relationship between P13K/Akt Signal Transduction Pathway and Cisplatin Resistance in Ovarian Carcinoma', 'publication_year': 2011, 'publication_date': '2011-01-01', 'ids': {'openalex': 'https://openalex.org/W2354175014', 'mag': '2354175014'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'http://en.cnki.com.cn/Article_en/CJFDTOTAL-TJYZ201104036.htm', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764905608', 'display_name': 'Tianjin yiyao', 'issn_l': '0253-9896', 'issn': ['0253-9896'], 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/P4328138118', 'host_organization_name': 'Tianjin Medical Information Institute', 'host_organization_lineage': ['https://openalex.org/P4328138118'], 'host_organization_lineage_names': ['Tianjin Medical Information Institute'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': [], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5100366103', 'display_name': 'Dong Zhang', 'orcid': 'https://orcid.org/0000-0002-3404-5173'}, 'institutions': [{'id': 'https://openalex.org/I5740404', 'display_name': 'Tianjin Medical University', 'ror': 'https://ror.org/02mh8wx89', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I5740404']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Zhang Dong', 'raw_affiliation_strings': ['First Central Clinical College of Tianjin Medical University, Tianjin 300192, China.'], 'affiliations': [{'raw_affiliation_string': 'First Central Clinical College of Tianjin Medical University, Tianjin 300192, China.', 'institution_ids': ['https://openalex.org/I5740404']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5026586197', 'display_name': 'Dexuan Kong', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Kong Dexuan', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5077904439', 'display_name': 'Zhenzhen He', 'orcid': 'https://orcid.org/0000-0001-9425-9555'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'HE Zhenzhen', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5006945651', 'display_name': 'Quanxin Qu', 'orcid': 'https://orcid.org/0000-0001-5460-625X'}, 'institutions': [{'id': 'https://openalex.org/I5740404', 'display_name': 'Tianjin Medical University', 'ror': 'https://ror.org/02mh8wx89', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I5740404']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'QU Quanxin', 'raw_affiliation_strings': ['First Central Clinical College of Tianjin Medical University, Tianjin 300192, China.'], 'affiliations': [{'raw_affiliation_string': 'First Central Clinical College of Tianjin Medical University, Tianjin 300192, China.', 'institution_ids': ['https://openalex.org/I5740404']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': False, 'cited_by_count': 1, 'citation_normalized_percentile': {'value': 0.0, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 65, 'max': 72}, 'biblio': {'volume': '39', 'issue': '4', 'first_page': '361', 'last_page': '363'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10550', 'display_name': 'Genomic Studies and Treatment of Ovarian Carcinoma', 'score': 0.8458, 'subfield': {'id': 'https://openalex.org/subfields/2743', 'display_name': 'Reproductive Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10550', 'display_name': 'Genomic Studies and Treatment of Ovarian Carcinoma', 'score': 0.8458, 'subfield': {'id': 'https://openalex.org/subfields/2743', 'display_name': 'Reproductive Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/ly294002', 'display_name': 'LY294002', 'score': 0.75158226}, {'id': 'https://openalex.org/keywords/mtt-assay', 'display_name': 'MTT assay', 'score': 0.55010396}, {'id': 'https://openalex.org/keywords/ovarian-cancer', 'display_name': 'Ovarian Cancer', 'score': 0.432124}], 'concepts': [{'id': 'https://openalex.org/C2778239845', 'wikidata': 'https://www.wikidata.org/wiki/Q412415', 'display_name': 'Cisplatin', 'level': 3, 'score': 0.8130574}, {'id': 'https://openalex.org/C86554907', 'wikidata': 'https://www.wikidata.org/wiki/Q285613', 'display_name': 'PI3K/AKT/mTOR pathway', 'level': 3, 'score': 0.8010207}, {'id': 'https://openalex.org/C75217442', 'wikidata': 'https://www.wikidata.org/wiki/Q423650', 'display_name': 'Protein kinase B', 'level': 3, 'score': 0.79452014}, {'id': 'https://openalex.org/C2776912716', 'wikidata': 'https://www.wikidata.org/wiki/Q4042503', 'display_name': 'LY294002', 'level': 4, 'score': 0.75158226}, {'id': 'https://openalex.org/C2780427987', 'wikidata': 'https://www.wikidata.org/wiki/Q172341', 'display_name': 'Ovarian cancer', 'level': 3, 'score': 0.5554138}, {'id': 'https://openalex.org/C2780783641', 'wikidata': 'https://www.wikidata.org/wiki/Q738686', 'display_name': 'MTT assay', 'level': 3, 'score': 0.55010396}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.51696247}, {'id': 'https://openalex.org/C3019054536', 'wikidata': 'https://www.wikidata.org/wiki/Q172341', 'display_name': 'Ovarian carcinoma', 'level': 4, 'score': 0.51322484}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.5056813}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.48547724}, {'id': 'https://openalex.org/C2776415932', 'wikidata': 'https://www.wikidata.org/wiki/Q48743', 'display_name': 'Western blot', 'level': 3, 'score': 0.46601704}, {'id': 'https://openalex.org/C62112901', 'wikidata': 'https://www.wikidata.org/wiki/Q189159', 'display_name': 'Cell growth', 'level': 2, 'score': 0.35664424}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.32033134}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.31781363}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.26836264}, {'id': 'https://openalex.org/C2776694085', 'wikidata': 'https://www.wikidata.org/wiki/Q974135', 'display_name': 'Chemotherapy', 'level': 2, 'score': 0.16531682}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.16099584}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.1506485}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.044252932}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'http://en.cnki.com.cn/Article_en/CJFDTOTAL-TJYZ201104036.htm', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764905608', 'display_name': 'Tianjin yiyao', 'issn_l': '0253-9896', 'issn': ['0253-9896'], 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/P4328138118', 'host_organization_name': 'Tianjin Medical Information Institute', 'host_organization_lineage': ['https://openalex.org/P4328138118'], 'host_organization_lineage_names': ['Tianjin Medical Information Institute'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W3172337443', 'https://openalex.org/W3118955068', 'https://openalex.org/W3030804573', 'https://openalex.org/W2392520152', 'https://openalex.org/W2389338019', 'https://openalex.org/W2388704363', 'https://openalex.org/W2387230382', 'https://openalex.org/W2385304218', 'https://openalex.org/W2384010676', 'https://openalex.org/W2378882265', 'https://openalex.org/W2374277338', 'https://openalex.org/W2365868923', 'https://openalex.org/W2365122994', 'https://openalex.org/W2362657623', 'https://openalex.org/W2356854638', 'https://openalex.org/W2356584608', 'https://openalex.org/W2354435179', 'https://openalex.org/W2324043560', 'https://openalex.org/W2174509842', 'https://openalex.org/W1576955805'], 'abstract_inverted_index': {'Objective:': [0], 'To': [1], 'investigate': [2], 'the': [3, 29, 49, 56, 68, 91], 'relationship': [4], 'between': [5], 'cisplatin': [6, 152], '(DDP)': [7], 'resistance': [8, 153], 'of': [9, 31, 51, 58, 70, 80, 89, 95, 106, 122, 159], 'ovarian': [10, 155, 160], 'carcinoma': [11], 'and': [12, 19, 40, 60, 73, 77, 97, 102, 108, 112, 124, 139], 'PI3K/Akt': [13, 146, 167], 'signal': [14], 'transduction': [15], 'pathway.': [16, 169], 'Methods:': [17], 'SKOV3': [18, 59, 76, 96, 111, 129], 'SKOV3/DDP': [20, 78, 98, 113, 134], 'cells': [21, 79, 99, 114, 130, 135], 'were': [22, 34, 115, 126], 'divided': [23], 'into': [24], '6': [25], 'groups': [26], 'depending': [27], 'on': [28, 55], 'concentration': [30], 'LY294002,': [32, 90], 'which': [33], '5': [35], 'μmol/L,10': [36], 'μmol/L,20': [37], 'μmol/L,40': [38], 'μmol/L,DDP': [39], 'control': [41], 'group.': [42, 82], 'MTT': [43], 'assay': [44], 'was': [45, 64], 'used': [46, 65], 'to': [47, 66, 93, 151], 'analyze': [48], 'effect': [50], '40': [52, 87], 'μmol/L': [53, 88], 'LY294002': [54], 'sensitivity': [57, 92], 'SKOV3/DDP.': [61], 'Western': [62], 'blot': [63], 'detect': [67], 'expressions': [69, 105], 'PI3K,': [71], 'Akt': [72, 109, 125], 'β-actin': [74], 'in': [75, 110, 128, 133, 154], 'each': [81], 'Results:': [83], 'After': [84], 'interference': [85], 'by': [86, 117, 165], 'DDP': [94], 'increased': [100], '67.36%': [101], '76.56%.': [103], 'The': [104, 119, 144, 157], 'PI3K': [107, 123], 'reduced': [116], 'LY294002.': [118], 'correspondence': [120], 'densities': [121], 'lower': [127], 'than': [131], 'those': [132], '(t': [136], '=': [137, 141], '26.005': [138], 't': [140], '23.477,P': [142], '0.05).Conclusion:': [143], 'abnormal': [145], 'signaling': [147, 168], 'pathway': [148], 'is': [149], 'related': [150], 'carcinoma.': [156], 'chemosensitivity': [158], 'cancer': [161], 'can': [162], 'be': [163], 'enhanced': [164], 'inhibiting': [166]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2354175014', 'counts_by_year': [{'year': 2014, 'cited_by_count': 1}], 'updated_date': '2024-09-25T11:45:54.240257', 'created_date': '2016-06-24'}