Title: Pharmacokinetic behavior and relative bioavailability of propylthiouracil sustained-release tablets vs market tablets in dogs
Abstract: AIM: To study the pharmacokinetic behavior and the relative bioavaila bility of propylthiouracil sustained-release tablets in beagle dogs, and to com pared wi th the market tablets. METHODS: The plasma concentration of propylthiouracil were determined by HPLC method foll owing a separated single oral dose of 150 mg of two kinds of tablets given to ( 6 d ogs) in an open randomized two-way crossover design. The 3P 97 computer progra m w as used to calculate the parameters and the relative biological availability and estimate the therapeutic equivalency between the two formulations. RESULTS: The plasma concentration-time profiles fitted to two-compartment-model after po admi nistrat ion. The main pharmacokinetic parameters MRT,t_(max), c_(ma x) were (5.3±s 0.6) h, ((2.4±)0.5) h and (15.6±2.0) mg·L~(-1) for sus tained-release tablet; (3.0±0.6) h, (1.1±0.3) h and (23.3±(2.9) mg·L~(-1 )) for market tablet, respectively. The relative biological availability of susta i ned-release tablet was (114±4) %. CONCLUSION: Propylthiouracil sustained-release tablets show bioequivalence to its market tablets with ability for maintaining the sustained release up to 12 h.
Publication Year: 2005
Publication Date: 2005-01-01
Language: en
Type: article
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