Title: Efficacy analysis of various doses of amiodarone in treatment of cardiac arrhythmia in elderly patients
Abstract: Objective To evaluate the clinical efficacy of various doses of amiodarone in the treatment of cardiac arrhythmia in elderly patients. Methods A total of 120 elderly patients with cardiac arrhythmia were randomly allocated to groups A, B, and C, and treated with high, medium, and low doses of oral amiodarone, respectively. The symptoms such as palpitation and chest distress were recorded, and the changes in dynamic electrocardiogram were measured in all groups before and after treatment. The maximum plasma concentration after medication was monitored in all groups. Results The overall response rates in the three groups were 82.5%, 80.0%, and 80.0%, respectively, and showed no significant difference between groups(P0.05). After treatment, the maximum plasma concentration in group A was significantly higher than that in groups B and C; meanwhile, group B showed a significantly higher concentration than group C(all P0.05). Groups A and B had a significantly faster onset of action than group C(P0.05), but no significant difference was observed between groups A and B(P0.05). Conclusion The loading dose and maintaining dose of oral amiodarone should be adjusted following the therapeutic effect in order to achieve the best treatment outcome with a minimal maintaining dose.
Publication Year: 2014
Publication Date: 2014-01-01
Language: en
Type: article
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