Title: Experimental study on the protective effect of pentoxifylline in Lipopolysacharide-induced acute lung injury
Abstract: Objective To explore a therapeutic method for acute lung injury.Methods Wistar rat models of Lipopolysacharide(LPS)-induced acute lung injury(ALI) were randomly divided into the model group(group A),the pentoxifylline group (group B)and the saline solution group (group C).The ratio of the neutrophile and the macrophage in the bronchoalveolar lavage fluid (BALF) and lung permeability index (LPI) were observed.The lung wet weight/dry weight and the pulmonary microvascular permeability index (PMPI)were also analyzed respectively.The serum Nitric oxide (NO),Endothelium(ET)levels and the lung inducible NO,ET levels and the lung inducible nitric oxide synthnase (iNOS)activity were analyzed.The surface and histological appearance of lung were observed under microscope and electromicroscope.Results There were more obvious changes in ratio of the neutrophile and the macrophage,LPT,lung wet weight/dry weight,PMPI,NO,ET,iNOS activity and the surface and histological appearance of lung in group B than that in group A,and there were no significantly difference in group B and in group C.Conclusion It suggests pentoxifylline can obvious improve the Lipopolysacharide-induced ALI. [
Publication Year: 2000
Publication Date: 2000-01-01
Language: en
Type: article
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