Publication Information

{'id': 'https://openalex.org/W2329583206', 'doi': 'https://doi.org/10.1093/chromsci/48.3.194', 'title': 'Development and Validation of a Direct LC-MS-MS Method to Determine the Acrolein Metabolite 3-HPMA in Urine', 'display_name': 'Development and Validation of a Direct LC-MS-MS Method to Determine the Acrolein Metabolite 3-HPMA in Urine', 'publication_year': 2010, 'publication_date': '2010-03-01', 'ids': {'openalex': 'https://openalex.org/W2329583206', 'doi': 'https://doi.org/10.1093/chromsci/48.3.194', 'mag': '2329583206', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/20223085'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1093/chromsci/48.3.194', 'pdf_url': 'https://academic.oup.com/chromsci/article-pdf/48/3/194/928324/48-3-194.pdf', 'source': {'id': 'https://openalex.org/S144192255', 'display_name': 'Journal of Chromatographic Science', 'issn_l': '0021-9665', 'issn': ['0021-9665', '1945-239X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://academic.oup.com/chromsci/article-pdf/48/3/194/928324/48-3-194.pdf', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5047110769', 'display_name': 'Wei‐Bin Yan', 'orcid': 'https://orcid.org/0000-0003-4204-3300'}, 'institutions': [{'id': 'https://openalex.org/I2802849423', 'display_name': 'University Medical Center', 'ror': 'https://ror.org/036pt7h44', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802849423']}, {'id': 'https://openalex.org/I47251452', 'display_name': 'Wake Forest University', 'ror': 'https://ror.org/0207ad724', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I47251452']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'W. Yan', 'raw_affiliation_strings': ['Department of Physiology and Pharmacology, Wake Forest University Medical Center, Winston-Salem, NC'], 'affiliations': [{'raw_affiliation_string': 'Department of Physiology and Pharmacology, Wake Forest University Medical Center, Winston-Salem, NC', 'institution_ids': ['https://openalex.org/I2802849423', 'https://openalex.org/I47251452']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5076728461', 'display_name': 'Gary D. Byrd', 'orcid': 'https://orcid.org/0000-0002-5437-9293'}, 'institutions': [{'id': 'https://openalex.org/I4210159832', 'display_name': 'Reynolds American (United States)', 'ror': 'https://ror.org/05qcjd272', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210159832']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'G. D. Byrd', 'raw_affiliation_strings': ['Clinical Studies Division, R.J. Reynolds Tobacco Company, Winston-Salem, NC 27102', 'East First Street, Suite 300, Winston-Salem, NC 27101'], 'affiliations': [{'raw_affiliation_string': 'Clinical Studies Division, R.J. Reynolds Tobacco Company, Winston-Salem, NC 27102', 'institution_ids': ['https://openalex.org/I4210159832']}, {'raw_affiliation_string': 'East First Street, Suite 300, Winston-Salem, NC 27101', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5010841832', 'display_name': 'Buddy G. Brown', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210159832', 'display_name': 'Reynolds American (United States)', 'ror': 'https://ror.org/05qcjd272', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210159832']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'B. G. Brown', 'raw_affiliation_strings': ['Clinical Studies Division, R.J. Reynolds Tobacco Company, Winston-Salem, NC 27102'], 'affiliations': [{'raw_affiliation_string': 'Clinical Studies Division, R.J. Reynolds Tobacco Company, Winston-Salem, NC 27102', 'institution_ids': ['https://openalex.org/I4210159832']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5076965809', 'display_name': 'Michael F. Borgerding', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210159832', 'display_name': 'Reynolds American (United States)', 'ror': 'https://ror.org/05qcjd272', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210159832']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'M. F. Borgerding', 'raw_affiliation_strings': ['Clinical Studies Division, R.J. Reynolds Tobacco Company, Winston-Salem, NC 27102'], 'affiliations': [{'raw_affiliation_string': 'Clinical Studies Division, R.J. Reynolds Tobacco Company, Winston-Salem, NC 27102', 'institution_ids': ['https://openalex.org/I4210159832']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 3, 'corresponding_author_ids': ['https://openalex.org/A5010841832'], 'corresponding_institution_ids': ['https://openalex.org/I4210159832'], 'apc_list': {'value': 4416, 'currency': 'USD', 'value_usd': 4416, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 0.563, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 21, 'citation_normalized_percentile': {'value': 0.815426, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 89, 'max': 90}, 'biblio': {'volume': '48', 'issue': '3', 'first_page': '194', 'last_page': '199'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11882', 'display_name': 'Biosynthesis and Engineering of Terpenoids', 'score': 0.9904, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11882', 'display_name': 'Biosynthesis and Engineering of Terpenoids', 'score': 0.9904, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10908', 'display_name': 'Chiral Separation in Chromatography', 'score': 0.9876, 'subfield': {'id': 'https://openalex.org/subfields/1607', 'display_name': 'Spectroscopy'}, 'field': {'id': 'https://openalex.org/fields/16', 'display_name': 'Chemistry'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T10836', 'display_name': 'Advances in Metabolomics Research', 'score': 0.9846, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/bioanalysis', 'display_name': 'Bioanalysis', 'score': 0.6744317}, {'id': 'https://openalex.org/keywords/high-performance-liquid-chromatography-(hplc)', 'display_name': 'High-Performance Liquid Chromatography (HPLC)', 'score': 0.534222}, {'id': 'https://openalex.org/keywords/liquid-chromatography', 'display_name': 'Liquid Chromatography', 'score': 0.517602}, {'id': 'https://openalex.org/keywords/mass-spectrometry', 'display_name': 'Mass Spectrometry', 'score': 0.505288}, {'id': 'https://openalex.org/keywords/matrix', 'display_name': 'Matrix (chemical analysis)', 'score': 0.50327915}, {'id': 'https://openalex.org/keywords/acrolein', 'display_name': 'Acrolein', 'score': 0.4957043}, {'id': 'https://openalex.org/keywords/solid-phase-extraction', 'display_name': 'Solid phase extraction', 'score': 0.48951852}, {'id': 'https://openalex.org/keywords/sample-preparation', 'display_name': 'Sample preparation', 'score': 0.44212648}], 'concepts': [{'id': 'https://openalex.org/C43617362', 'wikidata': 'https://www.wikidata.org/wiki/Q170050', 'display_name': 'Chromatography', 'level': 1, 'score': 0.9336382}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.9329787}, {'id': 'https://openalex.org/C10390740', 'wikidata': 'https://www.wikidata.org/wiki/Q2282401', 'display_name': 'Analyte', 'level': 2, 'score': 0.7221368}, {'id': 'https://openalex.org/C137535248', 'wikidata': 'https://www.wikidata.org/wiki/Q4914691', 'display_name': 'Bioanalysis', 'level': 2, 'score': 0.6744317}, {'id': 'https://openalex.org/C175467004', 'wikidata': 'https://www.wikidata.org/wiki/Q17088083', 'display_name': 'Ion suppression in liquid chromatography–mass spectrometry', 'level': 4, 'score': 0.6484735}, {'id': 'https://openalex.org/C119128265', 'wikidata': 'https://www.wikidata.org/wiki/Q900165', 'display_name': 'Detection limit', 'level': 2, 'score': 0.62042063}, {'id': 'https://openalex.org/C2780026642', 'wikidata': 'https://www.wikidata.org/wiki/Q40924', 'display_name': 'Urine', 'level': 2, 'score': 0.61499727}, {'id': 'https://openalex.org/C2777477808', 'wikidata': 'https://www.wikidata.org/wiki/Q407595', 'display_name': 'Metabolite', 'level': 2, 'score': 0.6000437}, {'id': 'https://openalex.org/C31827203', 'wikidata': 'https://www.wikidata.org/wiki/Q874296', 'display_name': 'Tandem mass spectrometry', 'level': 3, 'score': 0.53601503}, {'id': 'https://openalex.org/C106487976', 'wikidata': 'https://www.wikidata.org/wiki/Q685816', 'display_name': 'Matrix (chemical analysis)', 'level': 2, 'score': 0.50327915}, {'id': 'https://openalex.org/C2780422782', 'wikidata': 'https://www.wikidata.org/wiki/Q342790', 'display_name': 'Acrolein', 'level': 3, 'score': 0.4957043}, {'id': 'https://openalex.org/C81426234', 'wikidata': 'https://www.wikidata.org/wiki/Q1408763', 'display_name': 'Solid phase extraction', 'level': 3, 'score': 0.48951852}, {'id': 'https://openalex.org/C162356407', 'wikidata': 'https://www.wikidata.org/wiki/Q180809', 'display_name': 'Mass spectrometry', 'level': 2, 'score': 0.48726475}, {'id': 'https://openalex.org/C64489805', 'wikidata': 'https://www.wikidata.org/wiki/Q873864', 'display_name': 'Liquid chromatography–mass spectrometry', 'level': 3, 'score': 0.48292705}, {'id': 'https://openalex.org/C4725764', 'wikidata': 'https://www.wikidata.org/wiki/Q844704', 'display_name': 'Extraction (chemistry)', 'level': 2, 'score': 0.44815126}, {'id': 'https://openalex.org/C2778576202', 'wikidata': 'https://www.wikidata.org/wiki/Q2540164', 'display_name': 'Sample preparation', 'level': 2, 'score': 0.44212648}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C161790260', 'wikidata': 'https://www.wikidata.org/wiki/Q82264', 'display_name': 'Catalysis', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000111', 'descriptor_name': 'Acetylcysteine', 'qualifier_ui': 'Q000031', 'qualifier_name': 'analogs & derivatives', 'is_major_topic': True}, {'descriptor_ui': 'D000171', 'descriptor_name': 'Acrolein', 'qualifier_ui': 'Q000652', 'qualifier_name': 'urine', 'is_major_topic': True}, {'descriptor_ui': 'D002853', 'descriptor_name': 'Chromatography, Liquid', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': True}, {'descriptor_ui': 'D053719', 'descriptor_name': 'Tandem Mass Spectrometry', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': True}, {'descriptor_ui': 'D000111', 'descriptor_name': 'Acetylcysteine', 'qualifier_ui': 'Q000652', 'qualifier_name': 'urine', 'is_major_topic': False}, {'descriptor_ui': 'D000111', 'descriptor_name': 'Acetylcysteine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000171', 'descriptor_name': 'Acrolein', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D000171', 'descriptor_name': 'Acrolein', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002853', 'descriptor_name': 'Chromatography, Liquid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D057230', 'descriptor_name': 'Limit of Detection', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053719', 'descriptor_name': 'Tandem Mass Spectrometry', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1093/chromsci/48.3.194', 'pdf_url': 'https://academic.oup.com/chromsci/article-pdf/48/3/194/928324/48-3-194.pdf', 'source': {'id': 'https://openalex.org/S144192255', 'display_name': 'Journal of Chromatographic Science', 'issn_l': '0021-9665', 'issn': ['0021-9665', '1945-239X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/20223085', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1093/chromsci/48.3.194', 'pdf_url': 'https://academic.oup.com/chromsci/article-pdf/48/3/194/928324/48-3-194.pdf', 'source': {'id': 'https://openalex.org/S144192255', 'display_name': 'Journal of Chromatographic Science', 'issn_l': '0021-9665', 'issn': ['0021-9665', '1945-239X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 18, 'referenced_works': ['https://openalex.org/W1773662450', 'https://openalex.org/W1991429643', 'https://openalex.org/W1998139147', 'https://openalex.org/W2017675813', 'https://openalex.org/W2025919046', 'https://openalex.org/W2030230518', 'https://openalex.org/W2046877602', 'https://openalex.org/W2054939153', 'https://openalex.org/W2063087223', 'https://openalex.org/W2068585757', 'https://openalex.org/W2068718322', 'https://openalex.org/W2068922516', 'https://openalex.org/W2070453504', 'https://openalex.org/W2071607653', 'https://openalex.org/W2103021214', 'https://openalex.org/W2171924267', 'https://openalex.org/W2396231701', 'https://openalex.org/W4256653193'], 'related_works': ['https://openalex.org/W2945414994', 'https://openalex.org/W2922448956', 'https://openalex.org/W2921432291', 'https://openalex.org/W2920800677', 'https://openalex.org/W2128260758', 'https://openalex.org/W2106356549', 'https://openalex.org/W2004234097', 'https://openalex.org/W1993902436', 'https://openalex.org/W1966813481', 'https://openalex.org/W1569498778'], 'abstract_inverted_index': {'A': [0], 'new': [1], 'direct': [2], 'method': [3, 23, 66, 102], 'using': [4], 'liquid': [5, 41], 'chromatography-tandem': [6], 'mass': [7], 'spectrometry': [8], 'has': [9], 'been': [10], 'developed': [11], 'and': [12, 27, 59, 70, 81], 'validated': [13], 'for': [14, 97], 'quantitation': [15, 91], 'of': [16, 72, 90], '3-hydroxypropylmercapturic': [17], 'acid': [18], '(3-HPMA)': [19], 'in': [20], 'urine.': [21, 33], 'The': [22, 88, 95], 'is': [24], 'fast,': [25], 'simple,': [26], 'does': [28], 'not': [29], 'require': [30], 'extraction': [31], 'from': [32], 'Analyte': [34], 'was': [35, 47, 92], 'separated': [36], 'on': [37], 'a': [38, 50, 110], 'hydrophilic': [39], 'interaction': [40], 'chromatography': [42], 'column.': [43], 'Severe': [44], 'ion': [45], 'suppression': [46], 'circumvented': [48], 'by': [49, 100, 109], 'fast': [51], 'gradient': [52], 'after': [53], 'separation.': [54], 'Assay': [55], 'specificity,': [56], 'linearity,': [57], 'precision,': [58], 'accuracy': [60], 'met': [61], 'the': [62, 73], 'required': [63], 'FDA/CDER': [64], 'bioanalytical': [65], 'criteria.': [67], 'Matrix': [68], 'effect': [69], 'carryover': [71], 'assay': [74], 'were': [75, 85, 103], 'assessed.': [76], 'Urine': [77], 'sample': [78], 'storage': [79], 'stability': [80, 84], 'standard': [82], 'solution': [83], 'also': [86], 'tested.': [87], 'limit': [89], '22.0': [93], 'ng/mL.': [94], 'results': [96, 107], '3-HPMA': [98], 'obtained': [99, 108], 'our': [101], 'significantly': [104], 'correlated': [105], 'with': [106], 'contract': [111], 'lab.': [112]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2329583206', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 2}, {'year': 2014, 'cited_by_count': 2}, {'year': 2013, 'cited_by_count': 2}], 'updated_date': '2024-09-24T13:01:06.685341', 'created_date': '2016-06-24'}