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['https://openalex.org/W1977842380', 'https://openalex.org/W2002943458', 'https://openalex.org/W2037908643', 'https://openalex.org/W2040300260', 'https://openalex.org/W2050878327', 'https://openalex.org/W2056396767', 'https://openalex.org/W2068798128', 'https://openalex.org/W2070842387', 'https://openalex.org/W2074743488', 'https://openalex.org/W2082173168', 'https://openalex.org/W2094923153', 'https://openalex.org/W2123980341', 'https://openalex.org/W2406042886', 'https://openalex.org/W2409689146'], 'related_works': ['https://openalex.org/W4251987652', 'https://openalex.org/W4248271778', 'https://openalex.org/W2385975691', 'https://openalex.org/W2126469804', 'https://openalex.org/W2103500164', 'https://openalex.org/W2074267735', 'https://openalex.org/W2055411010', 'https://openalex.org/W2030524415', 'https://openalex.org/W1969203961', 'https://openalex.org/W1795904732'], 'abstract_inverted_index': {'digoxin': [0, 2, 14, 62], '0.25mg維持療法中の患者88例の血清': [1], '濃度を': [3], 'radioimmunoassay': [4], 'により測定し,': [5], '中毒・非中毒の2群,': [6], 'さらに老年者': [7], '(60歳以上)・若年者': [8], '(59歳以下)': [9], 'の2群に分けて,': [10], '両群間の臨床成績を比較検討した.': [11], '次いで,': [12], '臨床上容易に得られる15項目の因子を用い多変量解析により血清': [13], '濃度およびジギタリス中毒に影響する因子の評価を行った.(1)': [15], '中毒群の血清濃度は3.06±1.34ng/mlであり,': [16], '非中毒群の0.96±0.55ng/mlより有意に高かった(p<0.001).': [17], '中毒群は非中毒群に比し,': [18], '年齢が有意に高く,': [19], '腎機能の低下,': [20, 49], '体重の減少および心胸廓比の増大が認められた.': [21], '血清濃度が1.7~2.6ng/mlのレベルで,': [22], '中毒群と非中毒群のオーバーラップが存在した.(2)': [23], '老年者の血清濃度は1.60±1.21ng/mlであり,': [24], '若年者の0.87±0.67ng/mlより有意に高く': [25], '(p<0.001),': [26], '中毒頻度も老年者が圧倒的に多かった': [27], '(老年者24.5%;': [28], '若年者6.4%,': [29], 'p<0.05).': [30], '老年者は若年者に比し,': [31], '腎機能は有意に低下し,': [32], '体重は少なかった': [33], '(p<0.01).(3)': [34], '重回帰分析により,': [35], '血清濃度総分散の54.2%が15個の因子により説明可能であった.': [36], '血清クレアチニン,': [37], '体重が血清濃度に影響を及ぼす最も重要な因子であることが認められ,': [38], '寄与率はそれぞれ32.67%,': [39], '9.33%であった.': [40], '心胸廓比,': [41], 'spironolactone': [42], 'の併用は軽度ではあるが血清濃度に影響することが示唆された.': [43], 'また,': [44], '年齢それ自体の寄与率は低く,': [45], '有意な因子ではなかった.(4)': [46], 'ジギタリス中毒の判別分析より,': [47], '中毒の発現に寄与する有力な因子は順に,': [48], '心胸廓比の増大,': [50], '体重の減少および低K血症であった.': [51], '年齢自体は本検討でも有意な因子ではなかった.年齢自体が有意でない理由は,': [52], '主成分分析より,': [53], '加齢に伴う腎機能の低下が第一に評価され,': [54], '年齢が相対的に低く評価された可能性が示唆された.以上の検討より,': [55], '老年者では個々の症例の加齢に伴う腎機能の低下,': [56], '体重の減少,': [57], '基礎疾患の増悪,': [58], '電解質アンバランスなど多くの因子を介して血中濃度が上昇し,': [59], '中毒が起こりやすくなることが推論された.': [60], '老年者に画一的な': [61], '0.25mg維持量投与は過剰となりやすく,': [63], '投与量の慎重な決定と頻回の血清濃度測定を含む綿密な臨床的観察が必要と結論された.': [64]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2318619153', 'counts_by_year': [], 'updated_date': '2024-09-27T03:27:41.636011', 'created_date': '2016-06-24'}