Title: Relationship of the characteristics of enhanced-ultrasonography and biology of hepatocellular carcinoma
Abstract: Objective To probe the relationship of the characteristics of enhanced-ultrasonography and biology of hepatocellular carcinoma(HCC).Methods Clinically proved 26 HCC and 8 focal nodule hyperplasia (FNH) were examined by double real-time grey-scale contrast-enhanced ultrasound with an intravenous administration of SonoVue.All the cases were taken aspiration biopsy for pathological histological examination and FCM DNA analysis.According to the show of contrast enhancement,the cases of HCC were divided into two groups which were typical group with enhancement beginning time ≤20 s and beginning time ≤50 s and non-typical group with beginning time 50s.The results of enhanced-ultrasonography were compared with those of DNA analysis.Results Twenty-six HCC included 18 cases vested in typical group and 8 in non-typical group.Eight FNH were all vested in non-typical group.DNA analysis showed S period and G_2/M ratios of HCC which were vested in typical group were((37.6)±(7.3))% and((14.0)±(2.1))%,respectively,markedly higher than those of HCC which were vested in non-typical group [((23.4)±(6.7))% and((8.4)±(1.7))%,P(0.05)],and those of the latter were also higher than those of FNH [((2.3)±(0.5))% and((1.6)±(0.4))%,P(0.01)].Aneuploid peak appeared in(33.3%)(6/18) HCC which were vested in typical group and didn't appeared in non-typical group and FNH.One HCC in typical group with diameter(5.2) cm showed only a nodule with diameter(0.9) cm appeared enhancement and quick fadeaway and the other part didn't appeared enhancement.These two parts were all HCC in pathology examination,while the nodule part appeared aneuploid peak and the other only showed diploid in DNA analysis.Conclusions DNA analysis shows high proliferation state in HCC which are vested in typical group and low or no proliferation state in non-typical group and FNH,which indicated ultrasonic contrast shows not only reflect the hemodynamics change of HCC but also relates to its characteristics.
Publication Year: 2006
Publication Date: 2006-01-01
Language: en
Type: article
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