Title: Antihyperlipidemic Effect of Ethanolic Extract of Hibiscus rosa sinensis Flowers in Hyperlipidemic Rats
Abstract: A B S T R A C T The antihyperlipidemic activity of Hibiscus rosa sinensis flowers ethanolic extract was investigated in triton (400 mg/kg b.w.) induced and atherogenic diet-induced hyperlipidemic rats in comparison of a known antihyperlipidemic drug simvastatin (10 mg/kg body wt.). Dose selection was made on the basis of acute oral toxicity study (50 mg to 5000 mg/kg body weight) as per OECD guidelines. Oral administration of 500 mg/kg body wt. of the ethanolic extract of Hibiscus rosa sinensis flowers exhibited a significant reduction (p<0.01) in serum lipid parameters total cholesterol, triglycerides, low density lipoprotein (LDL), very low density lipopreotein (VLDL) and increase in high density lipoprotein (HDL) in hyperlipidemic rats in comparison with hyperlipidemic control in both models. The drug has the potential to act as antihyperlipidemic drug.
Publication Year: 2011
Publication Date: 2011-01-01
Language: en
Type: article
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Cited By Count: 17
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