Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2226889062', 'doi': 'https://doi.org/10.18632/oncotarget.5173', 'title': 'Sur8/Shoc2 promotes cell motility and metastasis through activation of Ras-PI3K signaling', 'display_name': 'Sur8/Shoc2 promotes cell motility and metastasis through activation of Ras-PI3K signaling', 'publication_year': 2015, 'publication_date': '2015-09-05', 'ids': {'openalex': 'https://openalex.org/W2226889062', 'doi': 'https://doi.org/10.18632/oncotarget.5173', 'mag': '2226889062', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/26384305', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/4741751'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.5173', 'pdf_url': 'https://www.oncotarget.com/article/5173/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://www.oncotarget.com/article/5173/pdf/', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5086381106', 'display_name': 'Saluja Kaduwal', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I193775966', 'display_name': 'Yonsei University', 'ror': 'https://ror.org/01wjejq96', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I193775966']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Saluja Kaduwal', 'raw_affiliation_strings': ['Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul, 120-749, Korea', 'Translational Research Center for Protein Function Control, Yonsei University, Seoul, 120-749, Korea'], 'affiliations': [{'raw_affiliation_string': 'Translational Research Center for Protein Function Control, Yonsei University, Seoul, 120-749, Korea', 'institution_ids': ['https://openalex.org/I193775966']}, {'raw_affiliation_string': 'Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul, 120-749, Korea', 'institution_ids': ['https://openalex.org/I193775966']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5029406323', 'display_name': 'Woo-Jeong Jeong', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I193775966', 'display_name': 'Yonsei University', 'ror': 'https://ror.org/01wjejq96', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I193775966']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Woo-Jeong Jeong', 'raw_affiliation_strings': ['Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul, 120-749, Korea', 'Translational Research Center for Protein Function Control, Yonsei University, Seoul, 120-749, Korea'], 'affiliations': [{'raw_affiliation_string': 'Translational Research Center for Protein Function Control, Yonsei University, Seoul, 120-749, Korea', 'institution_ids': ['https://openalex.org/I193775966']}, {'raw_affiliation_string': 'Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul, 120-749, Korea', 'institution_ids': ['https://openalex.org/I193775966']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101403397', 'display_name': 'Jong‐Chan Park', 'orcid': 'https://orcid.org/0000-0002-0799-7742'}, 'institutions': [{'id': 'https://openalex.org/I193775966', 'display_name': 'Yonsei University', 'ror': 'https://ror.org/01wjejq96', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I193775966']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Jong-Chan Park', 'raw_affiliation_strings': ['Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul, 120-749, Korea', 'Translational Research Center for Protein Function Control, Yonsei University, Seoul, 120-749, Korea'], 'affiliations': [{'raw_affiliation_string': 'Translational Research Center for Protein Function Control, Yonsei University, Seoul, 120-749, Korea', 'institution_ids': ['https://openalex.org/I193775966']}, {'raw_affiliation_string': 'Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul, 120-749, Korea', 'institution_ids': ['https://openalex.org/I193775966']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5016700477', 'display_name': 'Kug Hwa Lee', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I193775966', 'display_name': 'Yonsei University', 'ror': 'https://ror.org/01wjejq96', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I193775966']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Kug Hwa Lee', 'raw_affiliation_strings': ['Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul, 120-749, Korea', 'Translational Research Center for Protein Function Control, Yonsei University, Seoul, 120-749, Korea'], 'affiliations': [{'raw_affiliation_string': 'Translational Research Center for Protein Function Control, Yonsei University, Seoul, 120-749, Korea', 'institution_ids': ['https://openalex.org/I193775966']}, {'raw_affiliation_string': 'Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul, 120-749, Korea', 'institution_ids': ['https://openalex.org/I193775966']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5083762934', 'display_name': 'Young Mi Lee', 'orcid': 'https://orcid.org/0000-0002-7001-0189'}, 'institutions': [{'id': 'https://openalex.org/I193775966', 'display_name': 'Yonsei University', 'ror': 'https://ror.org/01wjejq96', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I193775966']}, {'id': 'https://openalex.org/I4210100154', 'display_name': 'Hanmi Pharmaceutical (South Korea)', 'ror': 'https://ror.org/013x1pp52', 'country_code': 'KR', 'type': 'company', 'lineage': ['https://openalex.org/I4210100154']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Young-Mi Lee', 'raw_affiliation_strings': ['Current address: Division of Pharmacology and Translational Research, Hanmi Research Center, Hwaseong-si Gyeonggi-do, 445-813, Korea', 'Translational Research Center for Protein Function Control, Yonsei University, Seoul, 120-749, Korea'], 'affiliations': [{'raw_affiliation_string': 'Translational Research Center for Protein Function Control, Yonsei University, Seoul, 120-749, Korea', 'institution_ids': ['https://openalex.org/I193775966']}, {'raw_affiliation_string': 'Current address: Division of Pharmacology and Translational Research, Hanmi Research Center, Hwaseong-si Gyeonggi-do, 445-813, Korea', 'institution_ids': ['https://openalex.org/I4210100154', 'https://openalex.org/I4210100154']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5033674097', 'display_name': 'Soung Hoo Jeon', 'orcid': 'https://orcid.org/0000-0002-4336-4491'}, 'institutions': [{'id': 'https://openalex.org/I193775966', 'display_name': 'Yonsei University', 'ror': 'https://ror.org/01wjejq96', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I193775966']}, {'id': 'https://openalex.org/I139264467', 'display_name': 'Seoul National University', 'ror': 'https://ror.org/04h9pn542', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I139264467']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Soung-Hoo Jeon', 'raw_affiliation_strings': ['Current address: Department of Microbiology and Immunology, Xenotransplantation Research Center, Medical Research Center, Institute of Endemic Disease, Seoul National University College of Medicine, Seoul, 110-799, Korea', 'Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul, 120-749, Korea', 'Translational Research Center for Protein Function Control, Yonsei University, Seoul, 120-749, Korea'], 'affiliations': [{'raw_affiliation_string': 'Translational Research Center for Protein Function Control, Yonsei University, Seoul, 120-749, Korea', 'institution_ids': ['https://openalex.org/I193775966']}, {'raw_affiliation_string': 'Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul, 120-749, Korea', 'institution_ids': ['https://openalex.org/I193775966']}, {'raw_affiliation_string': 'Current address: Department of Microbiology and Immunology, Xenotransplantation Research Center, Medical Research Center, Institute of Endemic Disease, Seoul National University College of Medicine, Seoul, 110-799, Korea', 'institution_ids': ['https://openalex.org/I139264467']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5033740987', 'display_name': 'Yong‐beom Lim', 'orcid': 'https://orcid.org/0000-0001-6590-7373'}, 'institutions': [{'id': 'https://openalex.org/I193775966', 'display_name': 'Yonsei University', 'ror': 'https://ror.org/01wjejq96', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I193775966']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Yong-Beom Lim', 'raw_affiliation_strings': ['Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul, 120-749, Korea', 'Department of Materials Science and Engineering, Yonsei University, Seoul, 120-749, Korea', 'Translational Research Center for Protein Function Control, Yonsei University, Seoul, 120-749, Korea'], 'affiliations': [{'raw_affiliation_string': 'Translational Research Center for Protein Function Control, Yonsei University, Seoul, 120-749, Korea', 'institution_ids': ['https://openalex.org/I193775966']}, {'raw_affiliation_string': 'Department of Materials Science and Engineering, Yonsei University, Seoul, 120-749, Korea', 'institution_ids': ['https://openalex.org/I193775966']}, {'raw_affiliation_string': 'Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul, 120-749, Korea', 'institution_ids': ['https://openalex.org/I193775966']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5032767655', 'display_name': 'Do Sik Min', 'orcid': 'https://orcid.org/0000-0002-8570-5098'}, 'institutions': [{'id': 'https://openalex.org/I193775966', 'display_name': 'Yonsei University', 'ror': 'https://ror.org/01wjejq96', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I193775966']}, {'id': 'https://openalex.org/I4921948', 'display_name': 'Pusan National University', 'ror': 'https://ror.org/01an57a31', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I4921948']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Do Sik Min', 'raw_affiliation_strings': ['Department of Molecular Biology, College of Natural Science, Pusan National University, Pusan, 609-735, Korea', 'Translational Research Center for Protein Function Control, Yonsei University, Seoul, 120-749, Korea'], 'affiliations': [{'raw_affiliation_string': 'Translational Research Center for Protein Function Control, Yonsei University, Seoul, 120-749, Korea', 'institution_ids': ['https://openalex.org/I193775966']}, {'raw_affiliation_string': 'Department of Molecular Biology, College of Natural Science, Pusan National University, Pusan, 609-735, Korea', 'institution_ids': ['https://openalex.org/I4921948']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5067941687', 'display_name': 'Kang‐Yell Choi', 'orcid': 'https://orcid.org/0000-0002-0952-3276'}, 'institutions': [{'id': 'https://openalex.org/I193775966', 'display_name': 'Yonsei University', 'ror': 'https://ror.org/01wjejq96', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I193775966']}], 'countries': ['KR'], 'is_corresponding': True, 'raw_author_name': 'Kang-Yell Choi', 'raw_affiliation_strings': ['Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul, 120-749, Korea', 'Translational Research Center for Protein Function Control, Yonsei University, Seoul, 120-749, Korea'], 'affiliations': [{'raw_affiliation_string': 'Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul, 120-749, Korea', 'institution_ids': ['https://openalex.org/I193775966']}, {'raw_affiliation_string': 'Translational Research Center for Protein Function Control, Yonsei University, Seoul, 120-749, Korea', 'institution_ids': ['https://openalex.org/I193775966']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 4, 'corresponding_author_ids': ['https://openalex.org/A5067941687'], 'corresponding_institution_ids': ['https://openalex.org/I193775966'], 'apc_list': None, 'apc_paid': None, 'fwci': 1.835, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 33, 'citation_normalized_percentile': {'value': 0.865308, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 94, 'max': 95}, 'biblio': {'volume': '6', 'issue': '32', 'first_page': '33091', 'last_page': '33105'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11533', 'display_name': 'Mammalian MAP Kinase Signaling Pathways', 'score': 0.9954, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11533', 'display_name': 'Mammalian MAP Kinase Signaling Pathways', 'score': 0.9954, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10379', 'display_name': 'Cell Mechanics and Extracellular Matrix Interactions', 'score': 0.9913, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10169', 'display_name': 'Molecular Mechanisms of Ras Signaling Pathways', 'score': 0.9908, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/ras-signaling', 'display_name': 'Ras Signaling', 'score': 0.542972}, {'id': 'https://openalex.org/keywords/erk-pathway', 'display_name': 'ERK pathway', 'score': 0.511437}], 'concepts': [{'id': 'https://openalex.org/C57074206', 'wikidata': 'https://www.wikidata.org/wiki/Q14197552', 'display_name': 'MAPK/ERK pathway', 'level': 3, 'score': 0.77277255}, {'id': 'https://openalex.org/C86554907', 'wikidata': 'https://www.wikidata.org/wiki/Q285613', 'display_name': 'PI3K/AKT/mTOR pathway', 'level': 3, 'score': 0.74740946}, {'id': 'https://openalex.org/C75217442', 'wikidata': 'https://www.wikidata.org/wiki/Q423650', 'display_name': 'Protein kinase B', 'level': 3, 'score': 0.62911844}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.623281}, {'id': 'https://openalex.org/C53645450', 'wikidata': 'https://www.wikidata.org/wiki/Q907093', 'display_name': 'Scaffold protein', 'level': 3, 'score': 0.5625276}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.5543178}, {'id': 'https://openalex.org/C2777658100', 'wikidata': 'https://www.wikidata.org/wiki/Q180614', 'display_name': 'Melanoma', 'level': 2, 'score': 0.4930739}, {'id': 'https://openalex.org/C58207958', 'wikidata': 'https://www.wikidata.org/wiki/Q33596', 'display_name': 'Motility', 'level': 2, 'score': 0.48957357}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.4822634}, {'id': 'https://openalex.org/C137738243', 'wikidata': 'https://www.wikidata.org/wiki/Q189092', 'display_name': 'Cell migration', 'level': 3, 'score': 0.4583189}, {'id': 'https://openalex.org/C184235292', 'wikidata': 'https://www.wikidata.org/wiki/Q421851', 'display_name': 'Kinase', 'level': 2, 'score': 0.44382593}, {'id': 'https://openalex.org/C2779013556', 'wikidata': 'https://www.wikidata.org/wiki/Q181876', 'display_name': 'Metastasis', 'level': 3, 'score': 0.44336295}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.40905827}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.36596704}, {'id': 'https://openalex.org/C1491633281', 'wikidata': 'https://www.wikidata.org/wiki/Q7868', 'display_name': 'Cell', 'level': 2, 'score': 0.33215028}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.21363789}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.060617656}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D002465', 'descriptor_name': 'Cell Movement', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D047908', 'descriptor_name': 'Intracellular Signaling Peptides and Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D019869', 'descriptor_name': 'Phosphatidylinositol 3-Kinases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D018631', 'descriptor_name': 'ras Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002465', 'descriptor_name': 'Cell Movement', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004815', 'descriptor_name': 'Epidermal Growth Factor', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D004815', 'descriptor_name': 'Epidermal Growth Factor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D057809', 'descriptor_name': 'HEK293 Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D047908', 'descriptor_name': 'Intracellular Signaling Peptides and Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008175', 'descriptor_name': 'Lung Neoplasms', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D008175', 'descriptor_name': 'Lung Neoplasms', 'qualifier_ui': 'Q000556', 'qualifier_name': 'secondary', 'is_major_topic': False}, {'descriptor_ui': 'D008175', 'descriptor_name': 'Lung Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008546', 'descriptor_name': 'Melanoma, Experimental', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D008546', 'descriptor_name': 'Melanoma, Experimental', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008546', 'descriptor_name': 'Melanoma, Experimental', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D041681', 'descriptor_name': 'NIH 3T3 Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009362', 'descriptor_name': 'Neoplasm Metastasis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019869', 'descriptor_name': 'Phosphatidylinositol 3-Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051057', 'descriptor_name': 'Proto-Oncogene Proteins c-akt', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051057', 'descriptor_name': 'Proto-Oncogene Proteins c-akt', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D048490', 'descriptor_name': 'raf Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D048490', 'descriptor_name': 'raf Kinases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D018631', 'descriptor_name': 'ras Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018631', 'descriptor_name': 'ras Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.5173', 'pdf_url': 'https://www.oncotarget.com/article/5173/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc4741751', 'pdf_url': 'https://europepmc.org/articles/pmc4741751?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741751', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/26384305', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.5173', 'pdf_url': 'https://www.oncotarget.com/article/5173/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.48, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 48, 'referenced_works': ['https://openalex.org/W1514421181', 'https://openalex.org/W1514816941', 'https://openalex.org/W1823067696', 'https://openalex.org/W1967265143', 'https://openalex.org/W1970527559', 'https://openalex.org/W1974223809', 'https://openalex.org/W1978116858', 'https://openalex.org/W1979346765', 'https://openalex.org/W1980952363', 'https://openalex.org/W1994634031', 'https://openalex.org/W2000297746', 'https://openalex.org/W2007649418', 'https://openalex.org/W2010304520', 'https://openalex.org/W2019958002', 'https://openalex.org/W2024452482', 'https://openalex.org/W2039750761', 'https://openalex.org/W2047401805', 'https://openalex.org/W2049992341', 'https://openalex.org/W2054044658', 'https://openalex.org/W2063099096', 'https://openalex.org/W2070732456', 'https://openalex.org/W2071359561', 'https://openalex.org/W2073891485', 'https://openalex.org/W2074060582', 'https://openalex.org/W2076931029', 'https://openalex.org/W2078663076', 'https://openalex.org/W2080198621', 'https://openalex.org/W2082225843', 'https://openalex.org/W2082827206', 'https://openalex.org/W2086641174', 'https://openalex.org/W2088293068', 'https://openalex.org/W2093265004', 'https://openalex.org/W2099273695', 'https://openalex.org/W2102424174', 'https://openalex.org/W2110889216', 'https://openalex.org/W2111244172', 'https://openalex.org/W2112668385', 'https://openalex.org/W2118474093', 'https://openalex.org/W2135000275', 'https://openalex.org/W2136396191', 'https://openalex.org/W2152854378', 'https://openalex.org/W2155311724', 'https://openalex.org/W2155959588', 'https://openalex.org/W2159594827', 'https://openalex.org/W2159856482', 'https://openalex.org/W2162889699', 'https://openalex.org/W2164837623', 'https://openalex.org/W2166731355'], 'related_works': ['https://openalex.org/W4214806664', 'https://openalex.org/W3142081545', 'https://openalex.org/W3047482297', 'https://openalex.org/W2483359251', 'https://openalex.org/W2391617054', 'https://openalex.org/W2078522456', 'https://openalex.org/W2058439546', 'https://openalex.org/W2038169799', 'https://openalex.org/W1994616212', 'https://openalex.org/W1988772505'], 'abstract_inverted_index': {'//': [0], 'Saluja': [1], 'Kaduwal': [2], '1,': [3, 8, 13, 19, 24, 30, 36, 42, 47], '2': [4, 9, 14, 20, 48, 62], ',': [5, 10, 15, 21, 27, 33, 38, 44], 'Woo-Jeong': [6], 'Jeong': [7], 'Jong-Chan': [11], 'Park': [12], 'Kug': [16], 'Hwa': [17], 'Lee': [18, 23], 'Young-Mi': [22], '2,': [25, 31], '5': [26, 104], 'Soung-Hoo': [28], 'Jeon': [29], '6': [32, 120], 'Yong-Beom': [34], 'Lim': [35], '3': [37, 77], 'Do': [39], 'Sik': [40], 'Min': [41], '4': [43, 89], 'Kang-Yell': [45, 149], 'Choi': [46], '1': [49], 'Translational': [50, 111], 'Research': [51, 114, 129, 132], 'Center': [52], 'for': [53], 'Protein': [54], 'Function': [55], 'Control,': [56], 'Yonsei': [57, 72, 84], 'University,': [58, 73, 85, 100], 'Seoul,': [59, 74, 86, 144], '120-749,': [60, 75, 87], 'Korea': [61, 76, 88, 103, 119, 146], 'Department': [63, 78, 90, 123], 'of': [64, 67, 79, 91, 95, 108, 124, 135, 142, 202, 231, 265, 274, 304, 314, 323, 337, 350], 'Biotechnology,': [65, 71], 'College': [66, 94, 141], 'Life': [68], 'Science': [69, 81], 'and': [70, 82, 110, 126, 212, 240, 242, 253, 261, 267, 276, 307, 346, 353], 'Materials': [80], 'Engineering,': [83], 'Molecular': [92], 'Biology,': [93], 'Natural': [96], 'Science,': [97], 'Pusan': [98], 'National': [99, 139], 'Pusan,': [101], '609-735,': [102], 'Current': [105, 121], 'address:': [106, 122], 'Division': [107], 'Pharmacology': [109], 'Research,': [112], 'Hanmi': [113], 'Center,': [115, 130, 133], 'Hwaseong-si': [116], 'Gyeonggi-do,': [117], '445-813,': [118], 'Microbiology': [125], 'Immunology,': [127], 'Xenotransplantation': [128], 'Medical': [131], 'Institute': [134], 'Endemic': [136], 'Disease,': [137], 'Seoul': [138], 'University': [140], 'Medicine,': [143], '110-799,': [145], 'Correspondence': [147], 'to:': [148], 'Choi,': [150], 'e-mail:': [151], '[email protected]': [152], 'Keywords:': [153], 'Sur8,': [154], 'Ras,': [155], 'PI3K,': [156], 'cell': [157, 259, 343], 'migration,': [158], 'metastasis': [159, 347], 'Received:': [160], 'June': [161], '02,': [162], '2015': [163, 167, 171], 'Accepted:': [164], 'August': [165], '26,': [166], 'Published:': [168], 'September': [169], '05,': [170], 'ABSTRACT': [172], 'Sur8': [173, 193, 225, 257, 280, 299, 324, 340], '(also': [174], 'known': [175], 'as': [176, 235, 237], 'Shoc2)': [177], 'is': [178, 329], 'a': [179, 199], 'Ras-Raf': [180], 'scaffold': [181, 200, 338], 'protein': [182, 201, 339], 'that': [183, 224, 292], 'modulates': [184], 'signaling': [185, 210], 'through': [186, 286, 348], 'extracellular': [187], 'signal-regulated': [188], 'kinase': [189], '(ERK)': [190], 'pathway.': [191, 288], 'Although': [192], 'has': [194, 218], 'been': [195, 220], 'shown': [196], 'to': [197, 333], 'be': [198], 'the': [203, 228, 321, 330, 335], 'Ras-ERK': [204], 'pathway,': [205], 'its': [206, 213], 'interaction': [207], 'with': [208, 227, 238], 'other': [209], 'pathways': [211], 'involvement': [214], 'in': [215, 247, 325, 341], 'tumor': [216], 'malignancy': [217], 'not': [219], 'reported.': [221], 'We': [222, 289], 'identified': [223], 'interacts': [226], 'p110α': [229], 'subunit': [230], 'phosphatidylinositol': [232], '3-kinase': [233], '(PI3K),': [234], 'well': [236], 'Ras': [239], 'Raf,': [241], 'these': [243, 282], 'interactions': [244], 'are': [245], 'increased': [246], 'an': [248], 'epidermal': [249], 'growth': [250], 'factor': [251], '(EGF)-': [252], 'oncogenic': [254], 'Ras-dependent': [255], 'manner.': [256], 'regulates': [258], 'migration': [260], 'invasion': [262], 'via': [263], 'activation': [264, 349], 'Rac': [266], 'matrix': [268], 'metalloproteinases': [269], '(MMPs).': [270], 'Interestingly,': [271], 'using': [272], 'inhibitors': [273], 'MEK': [275], 'PI3K': [277, 287, 354], 'we': [278], 'found': [279, 291], 'mediates': [281], 'cellular': [283], 'behaviors': [284], 'predominantly': [285], 'further': [290], 'human': [293], 'metastatic': [294, 312], 'melanoma': [295, 318, 326], 'tissues': [296], 'had': [297], 'higher': [298], 'content': [300], 'followed': [301], 'by': [302], 'activations': [303], 'Akt,': [305], 'ERK,': [306], 'Rac.': [308], 'Lentivirus-mediated': [309], 'Sur8-knockdown': [310], 'attenuated': [311], 'potential': [313], 'highly': [315], 'invasive': [316], 'B16-F10': [317], 'cells': [319], 'indicating': [320], 'role': [322, 336], 'metastasis.': [327], 'This': [328], 'first': [331], 'report': [332], 'identify': [334], 'regulating': [342], 'motility,': [344], 'invasion,': [345], 'both': [351], 'ERK': [352], 'pathways.': [355]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2226889062', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 4}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 7}, {'year': 2018, 'cited_by_count': 6}, {'year': 2017, 'cited_by_count': 3}, {'year': 2016, 'cited_by_count': 5}], 'updated_date': '2024-09-14T03:06:42.944157', 'created_date': '2016-06-24'}