Title: Synthesis, Spectroscopic Characterisation, In-Vitro Anticancer and Antimicrobial Activities of Some Metal(II) Complexes of 3-{4, 6-Dimethoxy Pyrimidinyl) Iminomethyl Naphthalen-2-ol
Abstract: The Schiff base, 3-{((4,6-dimethoxypyrimidin-2-yl)imino)methyl}naphthalen-2-ol and its VO(IV), Mn(II), Co(II), Ni(II), Cu(II), Zn(II) and Pd(II) complexes were synthesised and characterized by IR, electronic and Hnmr spectroscopies, elemental analysis and conductance measurements. The ligand coordinated to the 1 metal ions through the azomethine N and phenol O atoms, resulting in a 5-coordinate, square-pyramidal geometry for the VO(IV) complex and a 4-coordinate square planar/ tetrahedral geometry for the Mn(II), Co(II), Ni(II), Cu(II) and Zn(II) complexes. The complexes were non-electrolytes in nitromethane and melted within the temperature range 240-352°C. The in-vitro anticancer studies reveal that the Pd(II) and Cu(II) complexes had the best anticancer activity against MCF-7(Human breast adenocarcinoma) cells with IC values of 3.89 µM and 50 4.90 µM, which were within the same order of activity as Cis-platin; and the Pd(II) complex activity against HT- 29 (Colon carcinoma) cells was the best being about the same order as Cis-platin (7.0 µM) with an IC of 6.69 50 µM. The antimicrobial studies showed that the ligand and the Zn(II) complex exhibited broad-spectrum antibacterial activity against P. mirabilis, B. subtilis, B. cereus and S. typhi with inhibitory zones range of 7.0-21.0 mm and 10.0-19.0 mm respectively.
Publication Year: 2012
Publication Date: 2012-01-01
Language: en
Type: article
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Cited By Count: 12
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