Heterodimerization of Somatostatin and Opioid Receptors Cross-modulates Phosphorylation, Internalization, and Desensitization

Name: Work Video:
Duration: 3 min 30 s
Manuela Pfeiffer; Thomas Koch; Helmut Schröder; Magdalena Laugsch; Volker Höllt; Stefan Schulz
{'id': 'https://openalex.org/W2163240506', 'doi': 'https://doi.org/10.1074/jbc.m110373200', 'title': 'Heterodimerization of Somatostatin and Opioid Receptors Cross-modulates Phosphorylation, Internalization, and Desensitization', 'display_name': 'Heterodimerization of Somatostatin and Opioid Receptors Cross-modulates Phosphorylation, Internalization, and Desensitization', 'publication_year': 2002, 'publication_date': '2002-05-01', 'ids': {'openalex': 'https://openalex.org/W2163240506', 'doi': 'https://doi.org/10.1074/jbc.m110373200', 'mag': '2163240506', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/11896051'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m110373200', 'pdf_url': 'http://www.jbc.org/article/S002192582085042X/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'http://www.jbc.org/article/S002192582085042X/pdf', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5063387121', 'display_name': 'Manuela Pfeiffer', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I95793202', 'display_name': 'Otto-von-Guericke University Magdeburg', 'ror': 'https://ror.org/00ggpsq73', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I95793202']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Manuela Pfeiffer', 'raw_affiliation_strings': ['Department of Pharmacology and Toxicology, Otto-von-Guericke University, 39120 Magdeburg, Germany'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology and Toxicology, Otto-von-Guericke University, 39120 Magdeburg, Germany', 'institution_ids': ['https://openalex.org/I95793202']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5082827724', 'display_name': 'Thomas Koch', 'orcid': 'https://orcid.org/0000-0002-0417-5700'}, 'institutions': [{'id': 'https://openalex.org/I95793202', 'display_name': 'Otto-von-Guericke University Magdeburg', 'ror': 'https://ror.org/00ggpsq73', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I95793202']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Thomas Koch', 'raw_affiliation_strings': ['Department of Pharmacology and Toxicology, Otto-von-Guericke University, 39120 Magdeburg, Germany'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology and Toxicology, Otto-von-Guericke University, 39120 Magdeburg, Germany', 'institution_ids': ['https://openalex.org/I95793202']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5039512687', 'display_name': 'Helmut Schröder', 'orcid': 'https://orcid.org/0000-0003-2231-5081'}, 'institutions': [{'id': 'https://openalex.org/I95793202', 'display_name': 'Otto-von-Guericke University Magdeburg', 'ror': 'https://ror.org/00ggpsq73', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I95793202']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Helmut Schröder', 'raw_affiliation_strings': ['Department of Pharmacology and Toxicology, Otto-von-Guericke University, 39120 Magdeburg, Germany'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology and Toxicology, Otto-von-Guericke University, 39120 Magdeburg, Germany', 'institution_ids': ['https://openalex.org/I95793202']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5018420158', 'display_name': 'Magdalena Laugsch', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I95793202', 'display_name': 'Otto-von-Guericke University Magdeburg', 'ror': 'https://ror.org/00ggpsq73', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I95793202']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Magdalena Laugsch', 'raw_affiliation_strings': ['Department of Pharmacology and Toxicology, Otto-von-Guericke University, 39120 Magdeburg, Germany'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology and Toxicology, Otto-von-Guericke University, 39120 Magdeburg, Germany', 'institution_ids': ['https://openalex.org/I95793202']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5105215906', 'display_name': 'Volker Höllt', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I95793202', 'display_name': 'Otto-von-Guericke University Magdeburg', 'ror': 'https://ror.org/00ggpsq73', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I95793202']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Volker Höllt', 'raw_affiliation_strings': ['Department of Pharmacology and Toxicology, Otto-von-Guericke University, 39120 Magdeburg, Germany'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology and Toxicology, Otto-von-Guericke University, 39120 Magdeburg, Germany', 'institution_ids': ['https://openalex.org/I95793202']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5019869416', 'display_name': 'Stefan Schulz', 'orcid': 'https://orcid.org/0000-0002-5997-8885'}, 'institutions': [{'id': 'https://openalex.org/I95793202', 'display_name': 'Otto-von-Guericke University Magdeburg', 'ror': 'https://ror.org/00ggpsq73', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I95793202']}], 'countries': ['DE'], 'is_corresponding': True, 'raw_author_name': 'Stefan Schulz', 'raw_affiliation_strings': ['Department of Pharmacology and Toxicology, Otto-von-Guericke University, 39120 Magdeburg, Germany'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology and Toxicology, Otto-von-Guericke University, 39120 Magdeburg, Germany', 'institution_ids': ['https://openalex.org/I95793202']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5019869416'], 'corresponding_institution_ids': ['https://openalex.org/I95793202'], 'apc_list': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'apc_paid': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'fwci': 8.923, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 259, 'citation_normalized_percentile': {'value': 0.999975, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '277', 'issue': '22', 'first_page': '19762', 'last_page': '19772'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11178', 'display_name': 'Receptor Mechanisms and Signaling', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11178', 'display_name': 'Receptor Mechanisms and Signaling', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10814', 'display_name': 'Neuropeptides and Animal Physiology', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11016', 'display_name': 'Monoclonal and Polyclonal Antibodies Research', 'score': 0.9988, 'subfield': {'id': 'https://openalex.org/subfields/2741', 'display_name': 'Radiology, Nuclear Medicine and Imaging'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/internalization', 'display_name': 'Internalization', 'score': 0.76376003}, {'id': 'https://openalex.org/keywords/μ-opioid-receptor', 'display_name': 'μ-opioid receptor', 'score': 0.5470704}, {'id': 'https://openalex.org/keywords/homologous-desensitization', 'display_name': 'Homologous desensitization', 'score': 0.47058028}], 'concepts': [{'id': 'https://openalex.org/C139770010', 'wikidata': 'https://www.wikidata.org/wiki/Q1339807', 'display_name': 'Internalization', 'level': 3, 'score': 0.76376003}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.6972632}, {'id': 'https://openalex.org/C11960822', 'wikidata': 'https://www.wikidata.org/wiki/Q242736', 'display_name': 'Phosphorylation', 'level': 2, 'score': 0.5998283}, {'id': 'https://openalex.org/C2779779143', 'wikidata': 'https://www.wikidata.org/wiki/Q3493547', 'display_name': 'Desensitization (medicine)', 'level': 3, 'score': 0.57965326}, {'id': 'https://openalex.org/C14397066', 'wikidata': 'https://www.wikidata.org/wiki/Q14911924', 'display_name': 'μ-opioid receptor', 'level': 4, 'score': 0.5470704}, {'id': 'https://openalex.org/C2777803847', 'wikidata': 'https://www.wikidata.org/wiki/Q325101', 'display_name': 'Enkephalin', 'level': 4, 'score': 0.5346903}, {'id': 'https://openalex.org/C80115893', 'wikidata': 'https://www.wikidata.org/wiki/Q2067077', 'display_name': 'Somatostatin receptor', 'level': 3, 'score': 0.5268893}, {'id': 'https://openalex.org/C116569031', 'wikidata': 'https://www.wikidata.org/wiki/Q899107', 'display_name': 'Ligand (biochemistry)', 'level': 3, 'score': 0.52172077}, {'id': 'https://openalex.org/C2776297358', 'wikidata': 'https://www.wikidata.org/wiki/Q407166', 'display_name': 'Somatostatin', 'level': 2, 'score': 0.5082114}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.5065261}, {'id': 'https://openalex.org/C2778938600', 'wikidata': 'https://www.wikidata.org/wiki/Q389934', 'display_name': 'Agonist', 'level': 3, 'score': 0.5055003}, {'id': 'https://openalex.org/C135285700', 'wikidata': 'https://www.wikidata.org/wiki/Q38173', 'display_name': 'G protein-coupled receptor', 'level': 3, 'score': 0.4744174}, {'id': 'https://openalex.org/C92759361', 'wikidata': 'https://www.wikidata.org/wiki/Q5891436', 'display_name': 'Homologous desensitization', 'level': 4, 'score': 0.47058028}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.4335081}, {'id': 'https://openalex.org/C169760540', 'wikidata': 'https://www.wikidata.org/wiki/Q207011', 'display_name': 'Neuroscience', 'level': 1, 'score': 0.38830924}, {'id': 'https://openalex.org/C2781063702', 'wikidata': 'https://www.wikidata.org/wiki/Q427523', 'display_name': 'Opioid', 'level': 3, 'score': 0.318827}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.28430003}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.2674644}], 'mesh': [{'descriptor_ui': 'D011957', 'descriptor_name': 'Receptors, Opioid', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D013004', 'descriptor_name': 'Somatostatin', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D000577', 'descriptor_name': 'Amides', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D000577', 'descriptor_name': 'Amides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000701', 'descriptor_name': 'Analgesics, Opioid', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D000701', 'descriptor_name': 'Analgesics, Opioid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001921', 'descriptor_name': 'Brain', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D001921', 'descriptor_name': 'Brain', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002460', 'descriptor_name': 'Cell Line', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019281', 'descriptor_name': 'Dimerization', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004305', 'descriptor_name': 'Dose-Response Relationship, Drug', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004705', 'descriptor_name': 'Endocytosis', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D004705', 'descriptor_name': 'Endocytosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020875', 'descriptor_name': 'Enkephalin, Ala(2)-MePhe(4)-Gly(5)-', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D020875', 'descriptor_name': 'Enkephalin, Ala(2)-MePhe(4)-Gly(5)-', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004797', 'descriptor_name': 'Enzyme-Linked Immunosorbent Assay', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007150', 'descriptor_name': 'Immunohistochemistry', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007211', 'descriptor_name': 'Indoles', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D007211', 'descriptor_name': 'Indoles', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020128', 'descriptor_name': 'Inhibitory Concentration 50', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007700', 'descriptor_name': 'Kinetics', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008024', 'descriptor_name': 'Ligands', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008125', 'descriptor_name': 'Locus Coeruleus', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D008125', 'descriptor_name': 'Locus Coeruleus', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D008125', 'descriptor_name': 'Locus Coeruleus', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018613', 'descriptor_name': 'Microscopy, Confocal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010766', 'descriptor_name': 'Phosphorylation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011233', 'descriptor_name': 'Precipitin Tests', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011485', 'descriptor_name': 'Protein Binding', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017208', 'descriptor_name': 'Rats, Wistar', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011957', 'descriptor_name': 'Receptors, Opioid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013004', 'descriptor_name': 'Somatostatin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013997', 'descriptor_name': 'Time Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014162', 'descriptor_name': 'Transfection', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m110373200', 'pdf_url': 'http://www.jbc.org/article/S002192582085042X/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/11896051', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m110373200', 'pdf_url': 'http://www.jbc.org/article/S002192582085042X/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 33, 'referenced_works': ['https://openalex.org/W1539638522', 'https://openalex.org/W1559798894', 'https://openalex.org/W1571586310', 'https://openalex.org/W1595449036', 'https://openalex.org/W1654156243', 'https://openalex.org/W1852077611', 'https://openalex.org/W1954089873', 'https://openalex.org/W1986906801', 'https://openalex.org/W1988220230', 'https://openalex.org/W1988395319', 'https://openalex.org/W1996894796', 'https://openalex.org/W2003446134', 'https://openalex.org/W2011106443', 'https://openalex.org/W2031590523', 'https://openalex.org/W2039620626', 'https://openalex.org/W2046161078', 'https://openalex.org/W2046404790', 'https://openalex.org/W2064734596', 'https://openalex.org/W2081113306', 'https://openalex.org/W2084240593', 'https://openalex.org/W2094590111', 'https://openalex.org/W2095441352', 'https://openalex.org/W2095846787', 'https://openalex.org/W2096686163', 'https://openalex.org/W2100316115', 'https://openalex.org/W2101769320', 'https://openalex.org/W2110469184', 'https://openalex.org/W2116935908', 'https://openalex.org/W2143517945', 'https://openalex.org/W2156515964', 'https://openalex.org/W2167251366', 'https://openalex.org/W2170984209', 'https://openalex.org/W2182454632'], 'related_works': ['https://openalex.org/W48708315', 'https://openalex.org/W2429511732', 'https://openalex.org/W2414340276', 'https://openalex.org/W2405844234', 'https://openalex.org/W2111847843', 'https://openalex.org/W2102562515', 'https://openalex.org/W2090801567', 'https://openalex.org/W2056712485', 'https://openalex.org/W2036840401', 'https://openalex.org/W2026999737'], 'abstract_inverted_index': {'Heterodimerization': [0, 215, 236, 451, 541, 948], 'has': [1, 31, 237, 267, 542, 629, 949, 1188], 'been': [2, 33, 238, 269, 543, 630, 951, 1177, 1190, 1519], 'shown': [3, 38, 239, 274, 544, 952, 1195, 3950, 4020, 4035, 4231], 'to': [4, 18, 149, 171, 240, 254, 385, 407, 545, 632, 953, 1106, 1154, 1170, 1644, 1828, 1892, 1912, 2088, 2095, 2399, 2436, 2555, 2567, 2637, 2647, 2665, 2702, 2952, 2956, 3192, 3249, 3288, 3339, 3421, 3563, 3575, 3709, 3775, 3936, 4065, 4098], 'modulate': [5, 241, 633], 'the': [6, 82, 87, 134, 146, 150, 168, 172, 194, 204, 209, 242, 318, 323, 370, 382, 386, 404, 408, 430, 440, 445, 603, 623, 634, 680, 1067, 1148, 1155, 1197, 1255, 1260, 1267, 1271, 1286, 1325, 1333, 1349, 1358, 1380, 1639, 1645, 1648, 1663, 1701, 1795, 1799, 1809, 1824, 1842, 1921, 1929, 2006, 2062, 2096, 2225, 2286, 2346, 2455, 2557, 2562, 2597, 2619, 2625, 2630, 2648, 2651, 2747, 2811, 2934, 2953, 2957, 2960, 2965, 3101, 3147, 3167, 3184, 3260, 3326, 3358, 3361, 3366, 3441, 3465, 3469, 3482, 3538, 3593, 3631, 3636, 3688, 3692, 3717, 3722, 3754, 3766, 3782, 3785, 3788, 3853, 3857, 3891, 3948, 3989, 4002, 4033, 4059, 4076, 4092, 4095, 4136, 4154, 4235, 4257], 'ligand': [7, 135, 152, 174, 243, 371, 388, 410, 548, 595, 1359, 1377, 1382, 1877, 3730, 4077], 'binding,': [8, 244, 3731, 4165], 'signaling,': [9, 245], 'and': [10, 26, 43, 69, 86, 113, 126, 157, 178, 183, 191, 230, 246, 262, 279, 305, 322, 349, 362, 393, 414, 419, 427, 466, 475, 551, 588, 597, 625, 636, 686, 695, 892, 903, 1063, 1075, 1109, 1142, 1182, 1199, 1209, 1370, 1379, 1455, 1483, 1487, 1510, 1517, 1673, 1711, 1767, 1839, 1848, 1863, 1902, 1916, 1926, 1948, 1985, 2041, 2086, 2105, 2177, 2215, 2252, 2298, 2369, 2386, 2390, 2397, 2408, 2411, 2461, 2467, 2517, 2687, 2699, 2708, 2782, 2823, 2832, 2855, 2877, 2902, 2915, 2931, 2999, 3017, 3050, 3063, 3069, 3077, 3151, 3196, 3225, 3268, 3395, 3444, 3481, 3523, 3560, 3596, 3620, 3672, 3680, 3714, 3733, 3787, 3797, 3826, 3850, 3922, 3939, 3956, 3964, 3976, 3982, 4014, 4041, 4087, 4119, 4146, 4166, 4193, 4206, 4224, 4248, 4270], 'trafficking': [11, 247, 956, 1175], 'properties': [12, 139, 248, 375, 599, 1363, 1944, 4079], 'of': [13, 28, 41, 50, 81, 91, 111, 124, 140, 145, 159, 167, 180, 188, 193, 232, 249, 264, 277, 286, 317, 327, 347, 360, 376, 381, 395, 403, 416, 424, 429, 468, 554, 602, 620, 638, 679, 886, 900, 906, 957, 1061, 1132, 1139, 1147, 1184, 1270, 1278, 1285, 1339, 1367, 1372, 1647, 1811, 1832, 1844, 1900, 1928, 1945, 1987, 2010, 2043, 2066, 2267, 2275, 2326, 2473, 2564, 2578, 2611, 2621, 2629, 2633, 2642, 2675, 2677, 2776, 2819, 2851, 2959, 2967, 2994, 3090, 3108, 3174, 3183, 3227, 3242, 3262, 3271, 3283, 3308, 3314, 3330, 3348, 3370, 3400, 3440, 3447, 3450, 3455, 3461, 3502, 3542, 3592, 3599, 3602, 3609, 3611, 3677, 3691, 3700, 3725, 3762, 3815, 3881, 3920, 3980, 3991, 4061, 4069, 4080, 4085, 4094, 4204, 4215, 4227], 'G': [14, 94, 233, 250, 330, 469, 480, 923], 'protein-coupled': [15, 95, 234, 251, 331, 470, 481, 489, 924], 'receptors.': [16, 142, 235, 252, 378, 471, 1374], 'However,': [17, 143, 253, 379], 'what': [19, 255], 'extent': [20, 256, 2674], 'heterodimerization': [21, 40, 110, 129, 257, 276, 346, 365, 678, 1353], 'may': [22, 216, 258, 452], 'alter': [23, 133, 259, 369, 546, 954], 'agonist-induced': [24, 260, 1180], 'phosphorylation': [25, 177, 229, 261, 413, 465, 1138, 1146, 1181, 2676, 3720, 4000], 'desensitization': [27, 158, 179, 231, 263, 394, 415, 467, 1183, 1371], 'these': [29, 141, 265, 377, 1185, 1373, 3810, 3843, 4030], 'receptors': [30, 46, 266, 282, 482, 590, 628, 640, 684, 895, 1065, 1115, 1201, 3796, 3800, 4208], 'not': [32, 131, 186, 268, 367, 422, 1189, 1265, 1355, 3297, 3941, 4027, 4161, 4169], 'documented.': [34, 270], 'We': [35, 271, 1192, 4074], 'have': [36, 272, 1176, 1193, 1518], 'recently': [37, 273, 1194], 'that': [39, 223, 275, 459, 479, 601, 677, 1168, 1196, 1275, 1324, 1346, 1894, 1914, 1931, 3296, 3809, 3871, 3929, 4050, 4127, 4185, 4194], 'sst2A': [42, 83, 112, 125, 160, 184, 278, 319, 348, 361, 396, 420, 1198, 1261, 1281, 1326, 1654, 1901, 1915, 3786, 3795, 4086], 'sst3': [44, 51, 280, 287, 1272, 1279, 1287], 'somatostatin': [45, 84, 281, 320, 627, 943, 944, 3272, 3816, 4205], 'results': [47, 283, 896, 1072, 4122, 4211], 'in': [48, 115, 284, 351, 676, 897, 1043, 1073, 1174, 1215, 1769, 1780, 1808, 1841, 1939, 2017, 2021, 2073, 2179, 2229, 2350, 2561, 2613, 2779, 2875, 2880, 2919, 2933, 2976, 3022, 3118, 3141, 3244, 3259, 3325, 3334, 3365, 3387, 3416, 3473, 3512, 3537, 3557, 3570, 3581, 3687, 3801, 3903, 3933, 3951, 3968, 4006, 4021, 4036, 4053, 4058, 4105, 4123, 4174, 4212, 4221, 4232, 4244, 4266], 'inactivation': [49, 285, 1284], 'receptor': [52, 85, 96, 288, 321, 332, 605, 672, 925, 933, 945, 1045, 1071, 1077, 1327, 1335, 1655, 1692, 2259, 2612, 2622, 2640, 2653, 2678], 'function': [53, 289, 2620], '(Pfeiffer,': [54, 290], 'M.,': [55, 61, 291, 297], 'Koch,': [56, 292], 'T.,': [57, 293], 'Schröder,': [58, 294], 'H.,': [59, 295], 'Klutzny,': [60, 296], 'Kirscht,': [62, 298], 'S.,': [63, 299], 'Kreienkamp,': [64, 300], 'H.': [65, 301, 911, 1003, 1119, 1227, 1294, 1527, 1582, 1605, 1739, 2115, 2151, 2717], 'J.,': [66, 302], 'Höllt,': [67, 303], 'V.,': [68, 304], 'Schulz,': [70, 306], 'S.': [71, 307, 741, 796, 819, 909, 1001, 1030, 1095, 1117, 1231, 1237, 1298, 1304, 1531, 1537, 1555, 1578, 1603, 1733, 2119, 2125, 2145, 2721, 2727], '(2001)': [72, 308], 'J.': [73, 309, 653, 731, 765, 788, 794, 984, 1238, 1305, 1538, 1590, 1612, 1744, 2126, 2156, 2728], 'Biol.': [74, 310, 654, 766, 985, 1239, 1306, 1539, 1613, 1745, 2127, 2157, 2729], 'Chem.276,': [75, 311], '14027–14036).': [76, 312], 'Here': [77, 313, 1321], 'we': [78, 105, 314, 341, 1322, 3791], 'examine': [79, 315, 3781], 'dimerization': [80, 316], 'μ-opioid': [88, 324, 932, 1334, 1691], 'receptor,': [89, 325, 1149, 3790], 'members': [90, 326], 'closely': [92, 328, 1341], 'related': [93, 329, 1069, 1342], 'families.': [97, 333], 'In': [98, 334, 1496, 1883, 3897, 4143, 4279], 'coimmunoprecipitation': [99, 335], 'studies': [100, 336, 477], 'using': [101, 337, 1638, 1669, 1707, 1798, 1834, 1875, 2288, 2338, 2599, 2682, 2981, 3028, 3201, 3237, 3487, 3630, 3668, 3697, 3743, 3753, 3852, 4011], 'differentially': [102, 338, 1821], 'epitope-tagged': [103, 339, 1822], 'receptors,': [104, 340, 1823], 'provide': [106, 342], 'direct': [107, 343], 'evidence': [108, 344], 'for': [109, 345, 690, 693, 1113, 1348, 2219, 2292, 2329, 2363, 2425, 2450, 2525, 2544, 2603, 2937, 3004, 3115, 3143, 3159, 3378, 3431, 3529, 3550, 3578, 3997, 4135, 4153, 4191, 4200], 'MOR1': [114, 182, 350, 418, 1693, 1903, 1917, 3789, 3799, 3962, 4088], 'human': [116, 352, 929, 1216], 'embryonic': [117, 353, 493, 930, 1217], 'kidney': [118, 354, 931, 1218], '293': [119, 355, 1220, 1761, 2078, 3803], 'cells.': [120, 356, 1923, 1980, 2036, 3727, 3804, 3924, 4142, 4179], 'Unlike': [121, 357, 1345], 'heteromeric': [122, 358], 'assembly': [123, 359, 885], 'sst3,': [127, 363], 'sst2A-MOR1': [128, 147, 169, 195, 364, 383, 405, 431, 1352, 1949, 3882, 3930, 3992, 4024, 4070, 4081], 'did': [130, 366, 1264, 1354, 4160, 4168], 'substantially': [132, 368], 'binding': [136, 372, 549, 596, 1360, 1878, 1943, 1970, 2026, 3207, 3229, 3253, 3273, 3292, 3305, 3806, 3817, 3828, 4078, 4104, 4173, 4181], 'or': [137, 227, 373, 463, 507, 1361, 2012, 2068, 2100, 2278, 2319, 2377, 2388, 2446, 2586, 2767, 2828, 2859, 3112, 3137, 3322, 3328, 3332, 3368, 3374, 3384, 3407, 3414, 3540, 3546, 3554, 3567, 3653, 3759, 3914, 3916, 4102, 4113, 4115], 'coupling': [138, 374, 1362, 1641], 'exposure': [144, 166, 380, 402], 'heterodimer': [148, 170, 196, 206, 384, 406, 432, 442, 1039, 1257, 3877], 'sst2A-selective': [151, 387], 'L-779,976': [153, 389, 1378, 3331, 3373, 3413, 3545, 4139, 4159, 4238, 4281], 'induced': [154, 176, 390, 412, 1103, 1282], 'phosphorylation,': [155, 391, 1368], 'internalization,': [156, 392, 1369], 'as': [161, 163, 397, 399, 505, 1165, 1203, 1210, 1685, 1727, 1880, 1996, 2005, 2052, 2061, 2108, 2255, 2380, 2382, 2590, 2618, 2710, 3015, 3218, 3256, 3295, 3716, 4218, 4220, 4272], 'well': [162, 398, 2381, 3189, 4219], 'MOR1.': [164, 400], 'Similarly,': [165, 401], 'μ-selective': [173, 409, 4155], '[d-Ala2,Me-Phe4,Gly5-ol]enkephalin': [175, 411, 946], 'both': [181, 417, 547, 639, 1114, 4117], 'but': [185, 421, 1364], 'internalization': [187, 423], 'sst2A.': [189, 425], 'Cross-phosphorylation': [190, 426], 'cross-desensitization': [192, 428], 'were': [197, 200, 433, 436, 1384, 1490, 1515, 1632, 1763, 1789, 1806, 1826, 1869, 1904, 1918, 1932, 1972, 1991, 2028, 2047, 2080, 2093, 2175, 2227, 2261, 2283, 2305, 2348, 2392, 2404, 2434, 2457, 2523, 2537, 2553, 2571, 2594, 2662, 2693, 2706, 2749, 2813, 2841, 2871, 2896, 2928, 2989, 3013, 3019, 3026, 3085, 3103, 3127, 3149, 3169, 3209, 3275, 3316, 3343, 3363, 3426, 3497, 3534, 3614, 3638, 3666, 3707, 3736, 3773, 3845, 3888, 3901, 3940, 3966, 4004, 4026], 'selective;': [198, 434], 'they': [199, 435, 1160], 'neither': [201, 437, 4282], 'observed': [202, 438, 1347], 'with': [203, 208, 439, 444, 594, 1066, 1280, 1332, 1662, 1700, 1775, 1792, 2264, 2272, 2307, 2406, 2414, 2463, 2650, 2657, 2752, 2793, 2816, 2843, 2899, 2905, 2991, 3039, 3047, 3060, 3074, 3105, 3130, 3153, 3171, 3280, 3318, 3397, 3458, 3526, 3640, 3847, 3890, 3958, 4016, 4043, 4083, 4100, 4163, 4171, 4251, 4274], 'sst2A-sst3': [205, 441, 1256, 1350], 'nor': [207, 443], 'endogenously': [210, 446], 'expressed': [211, 447, 1207, 3715], 'lysophosphatidic': [212, 448, 3568], 'acid': [213, 449, 671, 683, 2918, 3569], 'receptor.': [214, 450], 'thus': [217, 453], 'represent': [218, 454], 'a': [219, 455, 1041, 1104, 1107, 1337, 1340, 1676, 1682, 1714, 1724, 1781, 1829, 2022, 2324, 2532, 2683, 2774, 2817, 2849, 2982, 2992, 3029, 3040, 3088, 3193, 3202, 3245, 3346, 3488, 3500, 3863, 3875, 3918, 3978, 4131, 4222], 'novel': [220, 456], 'regulatory': [221, 457], 'mechanism': [222, 458], 'could': [224, 460], 'either': [225, 461, 2308, 2437, 2753, 2815, 3319, 3412, 3564, 4111], 'restrict': [226, 462], 'enhance': [228, 464], 'Recent': [472], 'biochemical,': [473], 'biophysical,': [474], 'functional': [476, 697, 888, 1283], 'suggest': [478, 3928], '(GPCRs)': [483], '1The': [484], 'abbreviations': [485], 'used': [486, 1516, 1933, 3996], 'are:': [487], 'GPCRG': [488], 'receptorERKextracellular': [490], 'signal-regulated': [491, 927], 'kinasesHEKhuman': [492], 'kidneyMOR1μ-opioid': [494], 'receptorPAGEpolyacrylamide': [495], 'gel': [496, 935, 1642, 2668], 'electrophoresisPMAphorbol': [497], '12-myristate': [498, 938], '13-acetatePKCprotein': [499], 'kinase': [500, 941], 'CSS-14somatostatinsstsomatostatin': [501], 'receptorDAMGO[d-Ala2,Me-Phe4,Gly5-ol]enkephalinHAhemagglutinin': [502], 'can': [503], 'assemble': [504], 'homo-': [506], 'heterodimeric': [508], 'complexes': [509], '(1Bouvier': [510, 556], 'M.': [511, 557, 642, 846, 850, 973, 1223, 1229, 1290, 1296, 1416, 1523, 1529, 1557, 1580, 1584, 1735, 1737, 2111, 2117, 2147, 2149, 2713, 2719, 3423], 'Nat.': [512, 558], 'Rev.': [513, 559], 'Neurosci.': [514, 560, 1591], '2001;': [515, 528, 561, 574, 1032, 1097, 1241, 1308, 1541, 1747, 2129, 2159, 2731], '2:': [516, 562], '274-286Crossref': [517, 563], 'PubMed': [518, 536, 564, 582, 614, 664, 723, 776, 809, 830, 879, 918, 967, 995, 1010, 1055, 1126, 1249, 1316, 1441, 1549, 1572, 1595, 1623, 1755, 2137, 2167, 2739], 'Scopus': [519, 537, 565, 583, 615, 665, 724, 777, 810, 831, 880, 919, 968, 996, 1011, 1056, 1127, 1250, 1317, 1442, 1550, 1573, 1596, 1624, 1756, 2138, 2168, 2740], '(581)': [520, 566], 'Google': [521, 539, 567, 585, 617, 667, 726, 779, 812, 833, 882, 921, 970, 998, 1013, 1035, 1058, 1100, 1129, 1252, 1319, 1444, 1552, 1575, 1598, 1626, 1758, 2140, 2170, 2742], 'Scholar,': [522, 568, 727, 780, 813, 834, 971, 999, 1014, 1553, 1576, 1599, 2141], '2Devi': [523, 569], 'L.A.': [524, 570, 609, 962, 1024, 1050, 1089], 'Trends': [525, 571], 'Pharmacol.': [526, 572], 'Sci.': [527, 573, 1028, 1093], '22:': [529, 575], '532-537Abstract': [530, 576], 'Full': [531, 533, 577, 579, 659, 661, 771, 773, 990, 992, 1244, 1246, 1311, 1313, 1544, 1546, 1618, 1620, 1750, 1752, 2132, 2134, 2162, 2164, 2734, 2736], 'Text': [532, 534, 578, 580, 660, 662, 772, 774, 991, 993, 1245, 1247, 1312, 1314, 1545, 1547, 1619, 1621, 1751, 1753, 2133, 2135, 2163, 2165, 2735, 2737], 'PDF': [535, 581, 663, 775, 994, 1248, 1315, 1548, 1622, 1754, 2136, 2166, 2738], '(262)': [538, 584], 'Scholar).': [540, 586, 618, 668, 883, 922, 1036, 1059, 1101, 1130, 1253, 1320, 1627, 1759, 2171, 2743], 'affinity': [550, 692, 4134, 4190, 4199], 'signaling': [552, 598, 637], 'efficacy': [553, 899, 905], 'GPCRs': [555, 958, 1133], 'δ-': [587, 1062], 'κ-opioid': [589, 1064], 'form': [591], 'stable': [592, 1330], 'heterodimers': [593, 621, 1187, 1212, 1331, 3883, 3931, 3993, 4025, 4071, 4082], 'resembling': [600], 'κ2': [604], '(3Jordan': [606, 959, 1047], 'B.A.': [607, 960, 1016, 1048, 1081], 'Devi': [608, 961, 1023, 1049, 1088], 'Nature.': [610, 719, 805, 875, 914, 963, 1006, 1051, 1122], '1999;': [611, 768, 827, 964, 1052], '399:': [612, 965, 1053], '697-700Crossref': [613, 966, 1054], '(978)': [616, 969, 1057], 'Formation': [619], 'between': [622, 3784], 'sst1': [624], 'sst5': [626], 'found': [631], 'pharmacology': [635], '(4Rocheville': [641], 'Lange': [643, 974], 'D.C.': [644, 975], 'Kumar': [645, 976], 'U.': [646, 913, 977, 1005, 1029, 1094, 1121], 'Sasi': [647, 978], 'R.': [648, 739, 800, 815, 979, 1022, 1087, 1565, 1586, 1607], 'Patel': [649, 651, 980, 982], 'R.C.': [650, 981], 'Y.C.': [652, 983], 'Chem.': [655, 767, 986, 1240, 1307, 1540, 1614, 1746, 2128, 2158, 2730], '2000;': [656, 915, 987, 1007, 1123], '275:': [657, 988], '7862-7869Abstract': [658, 989], '(467)': [666, 997], 'The': [669, 1037, 1375, 1447, 1651, 1688, 1787, 1924, 1981, 2001, 2037, 2057, 2091, 2172, 2258, 2372, 2402, 2431, 2521, 2535, 2609, 2639, 2660, 2673, 2691, 2704, 2869, 2926, 2970, 3024, 3083, 3098, 3125, 3221, 3390, 3424, 3434, 3495, 3532, 3625, 4121, 4202], 'γ-aminobutyric': [670, 682], 'B': [673], 'is': [674, 688, 1134], 'unique': [675], 'nonfunctional': [681], 'B1': [685], 'B2': [687, 893], 'required': [689], 'native': [691], 'ligands': [694], 'complete': [696, 4067], 'activity': [698], '(5White': [699], 'J.H.': [700], 'Wise': [701], 'A.': [702, 706, 743, 798, 802, 823, 1031, 1096, 1422, 1426, 1561], 'Main': [703], 'M.J.': [704], 'Green': [705], 'Fraser': [707], 'N.J.': [708], 'Disney': [709], 'G.H.': [710], 'Barnes': [711], 'A.A.': [712, 1430], 'Emson': [713], 'P.': [714, 749, 792], 'Foord': [715], 'S.M.': [716, 1400], 'Marshall': [717], 'F.H.': [718], '1998;': [720, 806, 876, 1438, 1569, 1592, 1615], '396:': [721, 807, 877], '679-682Crossref': [722], '(1015)': [725], '6Ng': [728], 'G.Y.': [729], 'Clark': [730], 'Coulombe': [732], 'N.': [733, 735, 745, 1018, 1083], 'Ethier': [734], 'Hebert': [736], 'T.E.': [737], 'Sullivan': [738], 'Kargman': [740], 'Chateauneuf': [742], 'Tsukamoto': [744], 'McDonald': [746], 'T.': [747, 864, 1225, 1292, 1525, 1559, 1601, 1731, 2113, 2143, 2715], 'Whiting': [748], 'Mezey': [750], 'E.': [751, 1609, 1741, 2153], 'Johnson': [752, 849], 'M.P.': [753], 'Liu': [754], 'Q.': [755, 858], 'Kolakowski': [756], 'L.F.,': [757], 'Jr.': [758], 'Evans': [759], 'J.F.': [760], 'Bonner': [761], 'T.I.': [762], "O'Neill": [763], 'G.P.': [764], '274:': [769], '7607-7610Abstract': [770], '(193)': [778], '7Kaupmann': [781], 'K.': [782, 862], 'Malitschek': [783], 'B.': [784, 804, 838], 'Schuler': [785], 'V.': [786, 1235, 1302, 1535, 1567, 1588, 1611, 1743, 2123, 2155, 2725], 'Heid': [787], 'Froestl': [789], 'W.': [790], 'Beck': [791], 'Mosbacher': [793], 'Bischoff': [795], 'Kulik': [797], 'Shigemoto': [799], 'Karschin': [801], 'Bettler': [803], '683-687Crossref': [808], '(1017)': [811], '8Kuner': [814], 'Kohr': [816], 'G.': [817, 821], 'Grunewald': [818], 'Eisenhardt': [820], 'Bach': [822], 'Kornau': [824], 'H.C.': [825], 'Science.': [826, 1437], '283:': [828], '74-77Crossref': [829], '(502)': [832], '9Jones': [835], 'K.A.': [836], 'Borowsky': [837], 'Tamm': [839], 'J.A.': [840, 860], 'Craig': [841], 'D.A.': [842], 'Durkin': [843], 'M.M.': [844], 'Dai': [845], 'Yao': [847], 'W.J.': [848], 'Gunwaldsen': [851], 'C.': [852, 856, 874, 1563], 'Huang': [853], 'L.Y.': [854], 'Tang': [855], 'Shen': [857, 1401], 'Salon': [859], 'Morse': [861], 'Laz': [863], 'Smith': [865, 1431], 'K.E.': [866], 'Nagarathnam': [867], 'D.': [868], 'Noble': [869], 'S.A.': [870], 'Branchek': [871], 'T.A.': [872], 'Gerald': [873], '674-679Crossref': [878], '(925)': [881], 'Heteromeric': [884], 'fully': [887], 'AT1': [889], 'angiotensin': [890, 901], 'II': [891, 902, 4125], 'bradykinin': [894, 907], 'increased': [898, 1074], 'decreased': [904, 1076, 4213], '(10AbdAlla': [908, 1116], 'Lother': [910, 1002, 1118], 'Quitterer': [912, 1004, 1120], '407:': [916, 1008, 1124], '94-98Crossref': [917, 1009, 1125], '(436)': [920, 1012, 1128], 'extracellular': [926], 'kinases': [928], 'polyacrylamide': [934], 'electrophoresis': [936, 2669], 'phorbol': [937], '13-acetate': [939], 'protein': [940, 2268, 2559, 2627, 3315, 3610, 3626], 'C': [942], 'hemagglutinin': [947], 'also': [950, 1328, 4183], 'endocytotic': [955, 1111], '4Rocheville': [972], '10AbdAlla': [1000], '11Jordan': [1015], 'Trapaidze': [1017, 1082], 'Gomes': [1019, 1084], 'I.': [1020, 1085], 'Nivarthi': [1021, 1086], 'Proc.': [1025, 1090], 'Natl.': [1026, 1091], 'Acad.': [1027, 1092], '98:': [1033, 1098], '343-348PubMed': [1034, 1099], 'κ-δ': [1038], 'exhibited': [1040], 'decrease': [1042], 'agonist-mediated': [1044], 'endocytosis': [1046, 1162], 'Oligomerization': [1060], 'distantly': [1068], 'β2-adrenergic': [1070], 'endocytosis,': [1078], 'respectively': [1079], '(11Jordan': [1080], 'AT1-B2heterodimerization': [1102], 'switch': [1105], 'clathrin-': [1108], 'dynamin-dependent': [1110], 'pathway': [1112], 'Signaling': [1131], 'often': [1135], 'terminated': [1136, 3437, 3589], 'by': [1137, 1163, 1387, 1993, 2049, 2300, 2336, 2539, 2574, 2655, 2671, 2802, 2848, 2909, 2974, 3234, 3277, 3299, 3438, 3590, 3738, 3765, 4090, 4209], 'intracellular': [1140, 4216], 'serine': [1141], 'threonine': [1143], 'residues.': [1144], 'After': [1145, 2302, 2453, 3165, 3178, 3463, 3634], 'arrestins': [1150], 'are': [1151, 1937, 2003, 2059], 'frequently': [1152], 'recruited': [1153], 'plasma': [1156], 'membrane,': [1157], 'at': [1158, 1658, 1696, 2295, 2323, 2332, 2366, 2428, 2528, 2541, 2547, 2606, 2773, 2940, 3007, 3087, 3122, 3162, 3198, 3238, 3345, 3428, 3499, 3584, 3867], 'which': [1159, 2551], 'facilitate': [1161], 'serving': [1164], 'scaffolding': [1166], 'proteins': [1167, 2260], 'bind': [1169], 'clathrin.': [1171], 'Although': [1172], 'changes': [1173], 'clearly': [1178], 'documented,': [1179], 'GPCR': [1186, 1343], 'examined.': [1191], 'sst3somatostatin': [1200], 'exist': [1202], 'constitutive': [1204, 1211], 'homodimers': [1205, 4089], 'when': [1206, 1213, 3886], 'alone': [1208, 2379], 'coexpressed': [1214, 1919, 3793, 3812], '(HEK)': [1219], 'cells': [1221, 1762, 1788, 1825, 1930, 2079, 2092, 2226, 2373, 2383, 2403, 2433, 2456, 2522, 2692, 2705, 2748, 2812, 2870, 3084, 3102, 3126, 3148, 3217, 3342, 3362, 3425, 3496, 3533, 3811, 3844, 3887, 3910, 3934, 3984, 3999, 4003, 4109, 4129, 4148, 4187, 4196, 4245, 4252, 4267, 4275], '(12Pfeiffer': [1222, 1289, 1522, 2110, 2712], 'Koch': [1224, 1291, 1524, 1558, 2112, 2714], 'Schroder': [1226, 1293, 1526, 1604, 1738, 2114, 2150, 2716], 'Klutzny': [1228, 1295, 1528, 1736, 2116, 2148, 2718], 'Kirscht': [1230, 1297, 1530, 2118, 2720], 'Kreienkamp': [1232, 1299, 1532, 2120, 2722], 'H.J.': [1233, 1300, 1533, 2121, 2723], 'Hollt': [1234, 1301, 1534, 1566, 1587, 1610, 1742, 2122, 2154, 2724], 'Schulz': [1236, 1303, 1536, 1602, 1732, 2124, 2144, 2726], '276:': [1242, 1309, 1542, 1748, 2130, 2160, 2732], '14027-14036Abstract': [1243, 1310, 1543, 2131, 2733], '(290)': [1251, 1318, 1551, 2139, 2741], 'Whereas': [1254], 'behaved': [1258], 'like': [1259], 'homodimer,': [1262, 1273], 'it': [1263, 4047], 'reproduce': [1266], 'pharmacological': [1268], 'characteristics': [1269], 'suggesting': [1274, 3870], 'physical': [1276], 'interaction': [1277], 'subtype': [1288], 'report': [1323], 'forms': [1329], '(MOR1),': [1336], 'member': [1338], 'family.': [1344], 'heterodimer,': [1351], 'significantly': [1356], 'affect': [1357], 'promoted': [1365], 'cross-modulation': [1366], 'sst2-selective': [1376, 4137, 4236], 'sst3-selective': [1381], 'L-796,778': [1383], 'kindly': [1385], 'provided': [1386], 'Dr.': [1388], 'Susan': [1389], 'Rohrer': [1390], '(13Rohrer': [1391], 'S.P.': [1392], 'Birzin': [1393], 'E.T.': [1394], 'Mosley': [1395], 'R.T.': [1396], 'Berk': [1397], 'S.C.': [1398], 'Hutchins': [1399], 'D.M.': [1402], 'Xiong': [1403], 'Y.': [1404], 'Hayes': [1405], 'E.C.': [1406], 'Parmar': [1407], 'R.M.': [1408], 'Foor': [1409], 'F.': [1410], 'Mitra': [1411], 'S.W.': [1412], 'Degrado': [1413], 'S.J.': [1414, 1420], 'Shu': [1415], 'Klopp': [1417], 'J.M.': [1418, 1436], 'Cai': [1419], 'Blake': [1421], 'Chan': [1423], 'W.W.': [1424], 'Pasternak': [1425], 'Yang': [1427], 'L.': [1428], 'Patchett': [1429], 'R.G.': [1432], 'Chapman': [1433], 'K.T.': [1434], 'Schaeffer': [1435], '282:': [1439], '737-740Crossref': [1440], '(443)': [1443], 'Scholar)': [1445], '(Merck).': [1446], 'radioligand': [1448], '[125I-Tyr11]SS-14': [1449, 3284, 4101, 4172], '(74': [1450], 'TBq/mmol)': [1451], 'was': [1452, 1457, 1467, 1478, 1656, 1694, 1873, 1889, 1910, 2616, 2645, 2680, 2791, 2949, 2972, 3045, 3058, 3072, 3190, 3232, 3254, 3293, 3392, 3436, 3467, 3471, 3485, 3588, 3628, 3695, 3750, 3884, 3954, 4039, 4048], 'fromAmersham': [1453], 'Biosciences,': [1454], '[3H]DAMGO': [1456, 3228, 3243, 4103, 4164], 'from': [1458, 1469, 1479, 1491, 1765, 1977, 2033, 2103, 2285, 2596, 3187, 3214, 3247, 3286, 3337, 3419, 3573, 3729, 3842, 3909, 3917, 3970, 3973, 3977, 4108, 4177], '(PerkinElmer': [1459], 'Life': [1460], 'Sciences).': [1461], 'Mouse': [1462], 'monoclonal': [1463, 1474, 2310, 2313, 2755, 2758, 2821, 3642], 'anti-T7': [1464, 1486, 2584, 3111], 'tag': [1465, 1476, 1666, 1704], 'antibody': [1466, 1477, 1500, 1504, 1508, 1513, 2772, 2790, 3114, 3156, 3645, 3658, 3860], 'obtained': [1468, 1764, 2538], 'Novagen': [1470], '(Madison,': [1471], 'WI),': [1472], 'rat': [1473, 1653, 1690, 2312, 2757, 2820, 3854], 'anti-HA': [1475, 1488, 2582, 2822, 2831, 3113, 3855, 3960, 4012, 4045], 'Roche': [1480], 'Molecular': [1481], 'Biochemicals,': [1482], 'polyclonal': [1484, 1629, 2580, 3656], 'rabbit': [1485, 1498, 1506, 1511, 1630, 2316, 2581, 2761, 2764, 2769, 2825, 2830, 3000, 3110, 3655, 3959, 4044], 'antibodies': [1489, 2322, 2589, 2796, 2840, 2862, 3003, 3012, 3671], 'Gramsch': [1492, 1562], 'Laboratories': [1493], '(Schwabhausen,': [1494], 'Germany).': [1495, 2884], 'addition,': [1497, 1884], 'anti-sst2A': [1499, 1503, 2279, 2317, 2765, 2826, 2835, 2997, 3859, 4017], '(6291),': [1501, 2318, 2766], 'guinea-pig': [1502], '(GP3),': [1505], 'anti-MOR1': [1507, 2320, 2770, 3001], '(9998),': [1509], 'anti-sst3': [1512, 2587], '(7986)': [1514, 2588], 'characterized': [1520], 'extensively': [1521], '14Schulz': [1554], 'Schreff': [1556, 1579], 'Zimprich': [1560], 'Elde': [1564], 'Neuroscience.': [1568], '82:': [1570], '613-622Crossref': [1571], '(72)': [1574], '15Schulz': [1577], 'Schmidt': [1581], 'Handel': [1583], 'Przewlocki': [1585], 'Eur.': [1589], '10:': [1593], '3700-3708Crossref': [1594], '(98)': [1597], '16Koch': [1600], 'Wolf': [1606], 'Raulf': [1608], '273:': [1616], '13652-13657Abstract': [1617], '(176)': [1625], 'All': [1628], 'antisera': [1631], 'affinity-purified': [1633, 2315, 2579, 2760, 2763, 2768, 2824, 2829, 3109], 'against': [1634], 'their': [1635], 'immunizing': [1636], 'peptides': [1637], 'Sulfo-Link': [1640], 'according': [1643, 2955], 'instructions': [1646], 'manufacturer': [1649], '(Pierce).': [1650], 'wild-type': [1652, 1689], 'tagged': [1657, 1695], 'its': [1659, 1697], 'amino': [1660, 1698], 'terminus': [1661, 1699], 'T7': [1664], 'epitope': [1665, 1703], 'sequence': [1667, 1705], 'MASMTGGQQMG': [1668], 'polymerase': [1670, 1708], 'chain': [1671, 1709], 'reaction': [1672, 1710, 3435], 'subcloned': [1674, 1712], 'into': [1675, 1713, 2470], 'pcDNA3.1': [1677], 'expression': [1678, 1716, 1872, 2623], 'vector': [1679, 1717], '(Invitrogen)': [1680, 3121], 'containing': [1681, 1723, 1784, 1794, 2912, 3311, 3404, 3517], 'neomycin': [1683, 1796], 'resistance': [1684, 1726, 1797], 'described': [1686, 1728, 1881, 1997, 2053, 2109, 2256, 2591, 2711, 3219], 'previously.': [1687, 3220], 'HA': [1702], 'YPYDVPDYA': [1706], 'pEAK10': [1715], '(Edge': [1718], 'Bio': [1719], 'Systems,': [1720], 'Gaithersburg,': [1721], 'MD)': [1722], 'puromycin': [1725, 1851], 'previously': [1729], '(17Koch': [1730], 'Pfeiffer': [1734, 2146], 'Kahl': [1740, 2152], '31408-31414Abstract': [1749, 2161], '(146)': [1757, 2169], 'HEK': [1760, 2077, 3802], 'ATCC': [1766], 'grown': [1768, 2087, 2398, 2694, 3511], "Dulbecco's": [1770, 3513], 'modified': [1771, 3514], "Eagle's": [1772, 3515], 'medium': [1773, 2410, 3391, 3403, 3443, 3516, 3583, 3595], 'supplemented': [1774], '10%': [1776, 1785, 3617], 'fetal': [1777, 3519], 'calf': [1778, 3520], 'serum': [1779, 2786, 3521], 'humidified': [1782], 'atmosphere': [1783], 'CO2.': [1786], 'first': [1790], 'transfected': [1791, 1979, 2035, 2076, 3216], 'plasmids': [1793], 'calcium': [1800], 'phosphate': [1801, 2922], 'precipitation': [1802, 2231, 2475, 4008, 4056], 'method.': [1803, 3633], 'Stable': [1804], 'transfectants': [1805], 'selected': [1807, 1840], 'presence': [1810, 1843, 3261, 3327, 3367, 3539], '500': [1812, 1845], 'μg/ml': [1813, 1846, 1850, 2206, 2209, 2213, 2217, 2328, 2508, 2511, 2515, 2519, 2778], 'G418': [1814, 1847], '(Invitrogen).': [1815], 'To': [1816, 3779, 3987], 'generate': [1817], 'lines': [1818], 'coexpressing': [1819, 1866, 1896, 2384, 4116, 4246, 4268], 'two': [1820], 'subjected': [1827, 2636, 2664], 'second': [1830], 'round': [1831], 'transfection': [1833], 'FuGENE': [1835], '6': [1836, 3385, 3555], '(Roche': [1837], 'Diagnostics)': [1838], '1': [1849, 2208, 2212, 2220, 2327, 2471, 2510, 2514, 2526, 2777, 3106, 3120, 3263, 3300, 3448, 3528, 3559], '(Sigma).': [1852], 'Three': [1853], 'clones': [1854, 1859, 1865, 1895], 'expressing': [1855, 1860, 2374, 3911, 4110, 4253, 4276], 'T7sst2A': [1856, 2385, 2389, 3913, 3981, 4112, 4118, 4141, 4186, 4247, 4254, 4269], 'alone,': [1857, 1862], 'six': [1858, 3240], 'HAMOR1': [1861, 1868, 2378, 2391, 3915, 3971, 3983, 4114, 4145, 4195, 4249, 4271, 4277], 'four': [1864, 2013, 2069], 'T7sst2Aand': [1867], 'generated.': [1870], 'Receptor': [1871], 'monitored': [1874], 'saturation': [1876], 'assays': [1879, 1971, 2027, 3208, 3735, 4182], 'below.': [1882, 2257], 'quantitative': [1885], 'Western': [1886, 3684], 'blot': [1887, 3949, 4034], 'analysis': [1888, 1995, 2051, 3236, 3279, 3676, 3749, 3761], 'carried': [1890, 2572, 3751], 'out': [1891, 2573, 3752], 'ensure': [1893], '∼': [1897], '1:1': [1898], 'ratio': [1899, 3814], 'selected.': [1905], 'Finally,': [1906], 'double': [1907, 2809], 'immunofluorescent': [1908], 'staining': [1909], 'performed': [1911, 1973, 2016, 2029, 2072, 3210, 3696], 'validate': [1913], 'within': [1920], 'same': [1922, 2935], 'Bmax': [1925, 3269], 'KDvalues': [1927], 'throughout': [1934], 'this': [1935, 3872], 'study': [1936], 'given': [1938], 'Table': [1940, 4124, 4233], 'I.Table': [1941], 'ILigand': [1942], 'sst2A,': [1946], 'MOR1,': [1947], 'receptors[125I]SS-14': [1950], 'bindingKDBmaxT7sst2A-HAMOR1T7sst2AT7sst2A-HAMOR1T7sst2Anmfmol/mg': [1951], 'protein0.48': [1952], '±': [1953, 1955, 1957, 1959, 1962, 1964, 1966, 1968, 2008, 2064, 3821, 3832], '0.080.17': [1954], '0.022458': [1956], '418820': [1958], '19[3H]DAMGO': [1960], 'bindingKDBmaxT7sst2A-HAMOR1HAMOR1T7sst2A-HAMOR1HAMOR11.20': [1961], '0.071.22': [1963], '0.142986': [1965], '135574': [1967], '20Saturation': [1969], 'on': [1974, 2030, 2222, 2459, 2531, 2695, 2964, 3211, 3616, 3683], 'membranes': [1975, 2031, 2174, 2304, 2347, 3637, 4106, 4175], 'prepared': [1976, 2032, 2176, 3846, 3905, 4107, 4176], 'stably': [1978, 2034, 3215, 3792], 'dissociation': [1982, 2038, 3222, 4068], 'constant': [1983, 2039, 3223], '(KD)': [1984, 2040, 3224], 'number': [1986, 2042, 3226], '[3H]DAMGO-binding': [1988, 2044], 'sites': [1989, 2045, 3230, 3274, 3818, 3829], '(Bmax)': [1990, 2046, 3231], 'calculated': [1992, 2048, 2617, 3233, 3276], 'Scatchard': [1994, 2050, 3235, 3278], 'under': [1998, 2054, 3906, 3994, 4029], '"Experimental': [1999, 2055], 'Procedures."': [2000, 2056], 'data': [2002, 2058, 3926], 'presented': [2004, 2060], 'means': [2007, 2063], 'S.E.': [2009, 2065], 'three': [2011, 2067], 'independent': [2014, 2070], 'experiments': [2015, 2071, 2954, 3807], 'triplicate.': [2018, 2074], 'Open': [2019], 'table': [2020], 'new': [2023], 'tab': [2024], 'Saturation': [2025, 3206, 3805], 'Stably': [2075], 'plated': [2081, 2393], 'onto': [2082, 2394, 3094, 3352, 3506, 3622], 'poly-l-lysine-coated': [2083], '150-mm': [2084], 'dishes': [2085, 2396], '80%': [2089, 2400], 'confluence.': [2090, 2401], 'exposed': [2094, 2435, 2701, 3562, 3686], 'cross-linking': [2097, 3892, 4062], 'agents': [2098, 4063], 'bis(sulfosuccinimidyl)suberate': [2099, 3894], 'dithiobis-(succinimidylpropionate)': [2101], '(both': [2102], 'Pierce)': [2104], 'subsequently': [2106, 2370], 'lysed': [2107, 2228, 4005], '17Koch': [2142], 'cell': [2173, 3937, 4051], 'solubilized': [2178, 2524, 2631], 'detergent': [2180, 3848], 'buffer': [2181, 2232, 2291, 2352, 2476, 2602, 3475, 3849, 4057], '(20': [2182], 'mm': [2183, 2188, 2193, 2199, 2202, 2234, 2239, 2242, 2354, 2359, 2478, 2483, 2486, 2489, 2492, 2504, 3477], 'HEPES,': [2184], 'pH': [2185, 2236, 2361, 2480, 2924, 3479], '7.4,': [2186, 2237, 2481], '150': [2187, 2238, 2482], 'NaCl,': [2189, 2240, 2484], '5': [2190, 2241, 2485, 3579], 'mmEDTA,': [2191], '3': [2192], 'EGTA,': [2194], '4': [2195, 2333, 2529, 2548, 3123], 'mg/ml': [2196], 'β-dodecylmaltoside,': [2197], '10': [2198, 2205, 2216, 2273, 2488, 2491, 2507, 2518, 2576], 'iodoacetamide,': [2200], '0.2': [2201, 2503], 'phenylmethylsulfonyl': [2203, 2505], 'fluoride,': [2204, 2506], 'leupeptin,': [2207, 2509], 'pepstatin': [2210, 2512], 'A,': [2211, 2513], 'aprotinin,': [2214, 2516], 'bacitracin)': [2218], 'h': [2221, 2331, 2527, 2939, 3006, 3117, 3161, 3386, 3556], 'ice.': [2223], 'Alternatively,': [2224], 'radioimmune': [2230, 2474, 4007, 4055], '(50': [2233, 2477, 3476], 'Tris-HCl,': [2235, 2360, 2479], 'EDTA,': [2243, 2487], '1%': [2244, 2495, 2783], 'Nonidet': [2245, 2496], 'P-40,': [2246, 2497], '0.5%': [2247, 2498, 3518], 'sodium': [2248, 2499], 'deoxycholate,': [2249, 2500], '0.1%': [2250, 2501], 'SDS,': [2251, 2357, 2502], 'proteinase': [2253], 'inhibitors)': [2254], 'then': [2262, 2412, 2468, 2663, 2700, 2750, 2872, 3128, 3393, 3524, 3535, 3561], 'immunoprecipitated': [2263, 3851, 4010], '100': [2265, 2438, 2443, 3131, 3138, 3371, 3375, 3459, 3543, 3547], 'μl': [2266, 3173, 3182, 3601], 'A-agarose': [2269], 'beads': [2270, 2287, 2598], 'preloaded': [2271], 'μg': [2274, 2577, 3107, 3313], 'anti-HA,': [2276, 2314, 2759, 2762], 'anti-T7,': [2277, 2311, 2756], '(6291)': [2280, 2827, 3861], 'antibodies.': [2281, 2837], 'Immunocomplexes': [2282, 2593], 'eluted': [2284, 2595], 'SDS': [2289, 2600, 3604], 'sample': [2290, 2566, 2601, 2615, 2635, 2644, 2649, 2658, 3605, 3613, 3945], '20': [2293, 2451, 2604], 'min': [2294, 2365, 2427, 2546, 2605, 3580], '60': [2296, 2426, 2545, 2607, 3144], '°C': [2297, 2368, 2530, 3430], 'resolved': [2299], 'SDS-PAGE.': [2301], 'electroblotting,': [2303], 'incubated': [2306, 2751, 2814, 2990, 3152, 3317, 3364, 3427, 3536, 3639], 'mouse': [2309, 2754, 3641], '(9998)': [2321, 2771, 3002], 'concentration': [2325, 2775], '12': [2330], '°C,': [2334, 2549], 'followed': [2335, 2670, 2801, 2847, 2908, 3764], 'detection': [2337, 2342], 'an': [2339], 'enhanced': [2340, 3673], 'chemiluminescence': [2341], 'system.': [2343], 'When': [2344, 3839, 3947, 4032], 'indicated,': [2345], 'placed': [2349, 2458], 'stripping': [2351], '(100': [2353], '2-mercaptoethanol,': [2355], '2%': [2356], '62.5': [2358], '6.7)': [2362], '30': [2364], '55': [2367], 'reprobed.': [2371], 'T7sst2A,': [2375], 'T7sst3,': [2376], 'Mycsst3': [2387], '100-mm': [2395], 'washed': [2405, 2462], 'serum-': [2407], 'phosphate-free': [2409], 'labeled': [2413, 2432], '200': [2415, 3181], 'μCi/ml': [2416], 'carrier-free': [2417], '[32P]orthophosphate': [2418], '(285': [2419], 'Ci/mg': [2420], 'Pi;': [2421], 'ICN,': [2422], 'Eschwege,': [2423], 'Germany)': [2424, 2895, 3037], '37': [2429, 3429, 3585], '°C.': [2430, 2608, 3124, 3586], 'nm': [2439, 2444, 2448, 3132, 3135, 3139, 3200, 3372, 3376, 3544, 3548], 'L-779,976,': [2440, 3133, 3565], '1000': [2441, 2447, 2689, 3134], 'nmL-796,778,': [2442], 'SS-14,': [2445], 'DAMGO': [2449, 3333, 3377, 3415, 3549, 3827, 4167, 4192, 4260], 'min.': [2452, 3145, 3433], 'incubation,': [2454], 'ice': [2460], 'ice-cold': [2464, 3451], 'phosphate-buffered': [2465], 'saline': [2466, 2781], 'scraped': [2469], 'ml': [2472, 3399, 3449], 'NaF,': [2490], 'disodium': [2493], 'pyrophosphate,': [2494], 'bacitracin).': [2520], 'rotating': [2533], 'platform.': [2534], 'supernatants': [2536], 'centrifugation': [2540], '13,000': [2542], '×g': [2543], 'after': [2550], 'aliquots': [2552, 3307], 'taken': [2554], 'determine': [2556], 'total': [2558, 2626, 3678, 3710], 'content': [2560, 2628, 2641, 2654, 3484, 3627], 'supernatant': [2563, 3466], 'each': [2565, 2614, 2634, 2643, 3188, 3612], 'be': [2568, 3776], 'immunoprecipitated.': [2569], 'Immunoprecipitations': [2570], 'adding': [2575], 'tag,': [2583, 2585], 'above.': [2592], 'amount': [2610], 'times': [2624], 'fraction': [2632], 'immunoprecipitation.': [2638], 'normalized': [2646, 3708], 'least': [2652, 3239], 'dilution': [2656], 'buffer.': [2659, 3606], 'samples': [2661], '8%': [2666], 'SDS-polyacrylamide': [2667, 3618], 'autoradiography.': [2672], 'monomers': [2679, 3963], 'quantitated': [2681], 'Fuji': [2684], 'PhosphorImaging': [2685], 'system': [2686], 'BAS': [2688], 'software.': [2690, 3704, 3747], 'poly-l-lysine-treated': [2696, 3095, 3353, 3507], 'coverslips': [2697], 'overnight': [2698], 'agonists.': [2703], 'fixed': [2707, 3150], 'permeabilized': [2709], 'For': [2744, 2808, 2943, 3303], 'single': [2745, 3864], 'immunofluorescence,': [2746, 2810], 'Tris/phosphate-buffered': [2780], 'normal': [2784], 'goat': [2785], 'overnight.': [2787], 'Bound': [2788, 2838, 3010], 'primary': [2789, 2839, 3011], 'detected': [2792, 2842, 3014, 3862, 4015], 'biotinylated': [2794, 2844], 'secondary': [2795, 3670], '(1:100;': [2797], 'Vector,': [2798], 'Burlingame,': [2799], 'CA)': [2800], 'cyanine': [2803, 2852, 2856, 3056, 3070], '3.18-conjugated': [2804], 'streptavidin': [2805, 2854], '(Amersham': [2806, 3493], 'Biosciences).': [2807, 3494], 'mixture': [2818, 2850, 2993, 3919, 3979], 'guinea': [2833, 2995], 'pig': [2834, 2861, 2996], '(GP3)': [2836, 2998], 'anti-rabbit': [2845, 3155], 'antibodies,': [2846], '2.18-conjugated': [2853], '5.18-conjugated': [2857], 'anti-rat': [2858], 'anti-guinea': [2860], '(1:200,': [2863], 'Jackson': [2864], 'ImmunoResearch,': [2865], 'West': [2866], 'Grove,': [2867], 'PA).': [2868], 'dehydrated,': [2873], 'cleared': [2874], 'xylol,': [2876], 'permanently': [2878, 3020], 'mounted': [2879, 3021], 'DPX': [2881], '(Fluka,': [2882], 'Neu-Ulm,': [2883], 'Male': [2885], 'Wistar': [2886], 'rats': [2887], '(n': [2888], '=': [2889], '3,': [2890], '200–250': [2891], 'g;': [2892], 'Tierzucht,': [2893], 'Schönwalde,': [2894], 'deeply': [2897], 'anesthetized': [2898], 'chloral': [2900], 'hydrate': [2901], 'transcardially': [2903], 'perfused': [2904], "Tyrode's": [2906], 'solution': [2907, 3176, 3186], "Zamboni's": [2910], 'fixative': [2911, 2936], '4%': [2913], 'paraformaldehyde': [2914], '0.2%': [2916], 'picric': [2917], '0.1': [2920], 'm': [2921], 'buffer,': [2923, 4009], '7.4.': [2925], 'brains': [2927], 'rapidly': [2929], 'dissected': [2930], 'post-fixed': [2932], '2': [2938, 3091, 3116, 3160, 3530], 'room': [2941, 3008, 3163], 'temperature.': [2942, 3009, 3164], 'all': [2944], 'animal': [2945], 'procedures': [2946], 'ethical': [2947], 'approval': [2948], 'sought': [2950], 'prior': [2951, 3935], 'requirements': [2958], 'German': [2961], 'National': [2962, 3698], 'Act': [2963], 'Use': [2966], 'Experimental': [2968], 'Animals.': [2969], 'tissue': [2971], 'cryoprotected': [2973], 'immersion': [2975], '30%': [2977], 'sucrose': [2978], 'before': [2979], 'sectioning': [2980], 'freezing': [2983], 'microtome.': [2984], 'Free-floating': [2985], 'sections': [2986, 3018], '(30–40': [2987], 'μm)': [2988], '48–72': [3005], 'above,': [3016], 'DPX.': [3023], 'specimens': [3025], 'examined': [3027], 'Leica': [3030], 'TCS-NT': [3031], 'laser': [3032], 'scanning': [3033], 'confocal': [3034], 'microscope': [3035], '(Heidelberg,': [3036], 'equipped': [3038], 'krypton/argon': [3041], 'laser.': [3042], 'Cyanine': [3043], '2.18': [3044], 'imaged': [3046, 3059, 3073], '488-nm': [3048], 'excitation': [3049, 3062, 3076], '500–560-nm': [3051], 'band': [3052, 3065, 3865, 3873], 'pass': [3053, 3066, 3080], 'emission': [3054, 3067, 3081], 'filters,': [3055, 3068], '3.18': [3057], '568-nm': [3061], '570–630-nm': [3064], '5.18': [3071], '647-nm': [3075], '665-nm': [3078], 'long': [3079], 'filters.': [3082], 'seeded': [3086, 3344, 3498], 'density': [3089, 3347, 3501], '×': [3092, 3350, 3504], '105/well': [3093, 3351, 3505], '24-well': [3096], 'plates.': [3097], 'next': [3099, 3359], 'day,': [3100, 3360], 'preincubated': [3104, 3889], 'OPTIMEM': [3119, 3142, 3388, 3527, 3558], 'treated': [3129], 'DAMGO,': [3136, 3566], 'PMA': [3140], 'Subsequently,': [3146], 'peroxidase-conjugated': [3154, 3669], '(1:1000;': [3157], 'AmershamBiosciences)': [3158], 'washing,': [3166], 'plates': [3168], 'developed': [3170, 3667], '250': [3172, 3600], 'ABTS': [3175], '(Roche).': [3177], '10–30': [3179], 'min,': [3180], 'substrate': [3185], 'transferred': [3191], '96-well': [3194], 'plate': [3195], 'analyzed': [3197, 3737], '405': [3199], 'microplate': [3203], 'reader': [3204], '(Bio-Rad).': [3205], 'membrane': [3212, 3309, 3824, 3835, 3840], 'preparations': [3213], 'concentrations': [3241, 3282, 3335, 3417, 3571], 'range': [3246, 3690], '0.3': [3248, 3289], '9': [3250], 'nm.': [3251, 3290], 'Nonspecific': [3252, 3291], 'determined': [3255, 3486, 3629], 'radioactivity': [3257], 'bound': [3258], 'μm': [3264, 3301, 3409], 'unlabeled': [3265], 'DAMGO.': [3266, 4157], 'KD': [3267], 'values': [3270, 3770], 'increasing': [3281], 'ranging': [3285, 3336, 3418, 3572], '0.025': [3287], 'defined': [3294], 'displaced': [3298], 'SS-14.': [3302], 'competition': [3304], 'assays,': [3306, 4001], 'preparation': [3310], '25': [3312, 3405, 3408], '0.05': [3320, 3323, 3772], 'nm[125I-Tyr11]SS-14': [3321], 'nm[3H]DAMGO': [3324], 'absence': [3329, 3369, 3541, 4060], '10−12': [3338], '10−5m.': [3340], 'Transfected': [3341], '1.5': [3349, 3503], '22-mm': [3354, 3508], '12-well': [3355, 3509], 'dishes.': [3356], 'On': [3357], '0,': [3379], '0.5,': [3380], '1,': [3381, 3551], '2,': [3382, 3552], '4,': [3383, 3553], '1.': [3389], 'removed': [3394], 'replaced': [3396], '0.5': [3398], 'serum-free': [3401], 'RPMI': [3402, 3582], 'μmforskolin': [3406], 'forskolin': [3410], 'plus': [3411], '10−14': [3420, 3574], '10−6': [3422, 3576], '15': [3432], 'removal': [3439, 3591], 'culture': [3442, 3594], 'subsequent': [3445, 3597], 'addition': [3446, 3598], 'HCl/ethanol': [3452], '(1': [3453], 'volume': [3454], '1n': [3456], 'HCl': [3457], 'volumes': [3460], 'ethanol).': [3462], 'centrifugation,': [3464], 'evaporated,': [3468], 'residue': [3470], 'dissolved': [3472], 'TE': [3474], 'Tris-EDTA,': [3478], '7.5),': [3480], 'cAMP': [3483, 4217, 4285], 'commercially': [3489], 'available': [3490], 'radioimmunoassay': [3491], 'kit': [3492], 'dishes,': [3510], 'overnight,': [3522], 'pretreated': [3525], 'h.': [3531], 'M': [3577], 'Incubation': [3587], 'boiling': [3603], 'Equal': [3607], 'amounts': [3608], 'separated': [3615], 'gels': [3619], 'electroblotted': [3621], 'nitrocellulose': [3623], 'membranes.': [3624], 'BCA': [3632], 'blocking,': [3635], 'phospho-specific': [3643], 'anti-ERK1/2': [3644], 'clone': [3646], 'E10': [3647], '(New': [3648], 'England': [3649], 'Biolabs,': [3650], 'Beverly,': [3651], 'MA)': [3652], 'phosphorylation-independent': [3654], 'anti-ERK2': [3657], '(Santa': [3659], 'Cruz': [3660], 'Biotechnology,': [3661], 'Santa': [3662], 'Cruz,': [3663], 'CA).': [3664], 'Blots': [3665], 'chemiluminescence.': [3674], 'Densitometric': [3675], 'ERK2': [3679], 'phospho-ERK1/2': [3681], 'levels': [3682, 3706, 4214], 'blots': [3685], 'linear': [3689], 'x-ray': [3693], 'film': [3694], 'Institutes': [3699], 'Health': [3701], 'Image': [3702], '1.57': [3703], 'Phospho-ERK1/2': [3705], 'ERK1/2': [3711, 3719, 4228], 'per': [3712], 'lane': [3713], 'fold': [3718], 'over': [3721], 'basal': [3723], 'value': [3724], 'untreated': [3726], 'Data': [3728], 'cAMP,': [3732], 'ERK': [3734], 'nonlinear': [3739], 'regression': [3740], 'curve': [3741], 'fitting': [3742], 'GraphPad': [3744], 'Prism': [3745], '3.0': [3746], 'Statistical': [3748], 'two-tailed': [3755], 'paired': [3756], 't': [3757], 'test': [3758, 3988], 'two-way': [3760], 'variance': [3763], 'Bonferroni': [3767], 'test.': [3768], 'p': [3769], '<': [3771], 'considered': [3774], 'statistically': [3777], 'significant.': [3778], 'directly': [3780], 'association': [3783], 'T7-tagged': [3794], 'HA-tagged': [3798], 'revealed': [3808, 3967, 4184], '∼1:1': [3813], '(Bmax': [3819, 3830], '2,458': [3820], '418': [3822], 'fmol/mg': [3823, 3834], 'protein)': [3825, 3836], '2,986': [3831], '135': [3833], '(Table': [3837], 'I).': [3838], 'extracts': [3841], 'antibody,': [3856, 3961, 4013, 4046], 'carboxyl-terminal': [3858], 'migrating': [3866], '160': [3868], 'kDa,': [3869], 'represents': [3874], 'T7sst2A-HAMOR1': [3876, 3974, 4128, 4147, 4178], '(Fig.': [3878, 3895, 3985, 4072], '1A).': [3879, 3896], 'Immunoprecipitation': [3880], 'facilitated': [3885], 'agent': [3893], 'contrast,': [3898, 4144, 4280], 'no': [3899, 4189, 4198], 'bands': [3900], 'detectable': [3902, 4028], 'immunoprecipitates': [3904, 3969], 'identical': [3907], 'conditions': [3908, 3995], 'only': [3912], 'T7sst2A-': [3921], 'HAMOR1-expressing': [3923], 'These': [3925], 'strongly': [3927], 'pre-existed': [3932], 'lysis': [3938, 4052], 'artificially': [3942], 'formed': [3943], 'during': [3944], 'preparation.': [3946], 'Fig.': [3952, 4022, 4037], '1A': [3953], 'stripped': [3955, 4040], 'reprobed': [3957, 4042], 'dimers': [3965], 'cells,': [3972, 3975], '1A′).': [3986], 'stability': [3990], 'whole': [3998], 'antibody.': [4018], 'As': [4019, 4230], '1B,': [4023], 'conditions.': [4031], '1B': [4038], 'apparent': [4049], 'SDS-containing': [4054], 'leads': [4064], 'nearly': [4066], '1B′).': [4073], 'compared': [4075, 4250, 4273], 'those': [4084], 'examining': [4091], 'ability': [4093], 'selective': [4096], 'agonists': [4097, 4210], 'compete': [4099, 4162, 4170], 'HAMOR1.': [4120], 'show': [4126], 'had': [4130, 4149, 4188, 4197], '2-fold': [4132], 'lower': [4133], 'agonist': [4138, 4156, 4237, 4259], 'than': [4140], 'similar': [4150], 'high': [4151], 'affinities': [4152], 'Moreover,': [4158], 'Ligand': [4180], 'L-779,976.': [4201], 'activation': [4203], 'opioid': [4207], 'rapid': [4223], 'transient': [4225], 'stimulation': [4226], 'phosphorylation.': [4229], 'II,': [4234], 'produced': [4239, 4261], '2–4-fold': [4240], 'more': [4241, 4263], 'robust': [4242, 4264], 'responses': [4243, 4265], 'alone.': [4255, 4278], 'Conversely,': [4256], 'MOR1-selective': [4258], 'slightly': [4262], 'inhibited': [4283], 'forskolin-stimulated': [4284], 'accumula': [4286]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2163240506', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 9}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 7}, {'year': 2018, 'cited_by_count': 9}, {'year': 2017, 'cited_by_count': 5}, {'year': 2016, 'cited_by_count': 6}, {'year': 2015, 'cited_by_count': 4}, {'year': 2014, 'cited_by_count': 15}, {'year': 2013, 'cited_by_count': 18}, {'year': 2012, 'cited_by_count': 13}], 'updated_date': '2024-12-27T03:22:51.696536', 'created_date': '2016-06-24'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
